The miRNA biogenesis in marine bivalves
Small non-coding RNAs include powerful regulators of gene expression, transposon mobility and virus activity. Among the various categories, mature microRNAs (miRNAs) guide the translational repression and decay of several targeted mRNAs. The biogenesis of miRNAs depends on few gene products, essenti...
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ftunivpadovairis:oai:www.research.unipd.it:11577/3181948 2024-04-21T08:00:35+00:00 The miRNA biogenesis in marine bivalves ROSANI, UMBERTO VENIER, PAOLA Pallavicini A Rosani, Umberto Pallavicini, A Venier, Paola 2016 http://hdl.handle.net/11577/3181948 https://doi.org/10.7717/peerj.1763 eng eng PEERJ INC (LONDON, ENGLAND) info:eu-repo/semantics/altIdentifier/pmid/26989613 info:eu-repo/semantics/altIdentifier/wos/WOS:000371663100001 volume:4 firstpage:1 lastpage:25 numberofpages:25 journal:PEERJ http://hdl.handle.net/11577/3181948 doi:10.7717/peerj.1763 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84963967637 miRNA biogenesis Mytilus galloprovincialis Crassostrea gigas Bivalves RNAi info:eu-repo/semantics/article 2016 ftunivpadovairis https://doi.org/10.7717/peerj.1763 2024-03-28T01:54:52Z Small non-coding RNAs include powerful regulators of gene expression, transposon mobility and virus activity. Among the various categories, mature microRNAs (miRNAs) guide the translational repression and decay of several targeted mRNAs. The biogenesis of miRNAs depends on few gene products, essentially conserved from basal to higher metazoans, whose protein domains allow specific interactions with dsRNA. Here, we report the identification of key genes responsible of the miRNA biogenesis in 32 bivalves, with particular attention to the aquaculture species Mytilus galloprovincialis and Crassostrea gigas. In detail, we have identified and phylogenetically compared eight evolutionary conserved proteins: DROSHA, DGCR8, EXP5, RAN, DICER TARBP2, AGO and PIWI. In mussels, we recognized several other proteins participating in the miRNA biogenesis or in the subsequent RNA silencing. According to digital expression analysis, these genes display low and not inducible expression levels in adult mussels and oysters whereas they are considerably expressed during development. As miRNAs play an important role also in the antiviral responses, knowledge on their production and regulative effects can shed light on essential molecular processes and provide new hints for disease prevention in bivalves. Article in Journal/Newspaper Crassostrea gigas Padua Research Archive (IRIS - Università degli Studi di Padova) PeerJ 4 e1763 |
institution |
Open Polar |
collection |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
op_collection_id |
ftunivpadovairis |
language |
English |
topic |
miRNA biogenesis Mytilus galloprovincialis Crassostrea gigas Bivalves RNAi |
spellingShingle |
miRNA biogenesis Mytilus galloprovincialis Crassostrea gigas Bivalves RNAi ROSANI, UMBERTO VENIER, PAOLA Pallavicini A The miRNA biogenesis in marine bivalves |
topic_facet |
miRNA biogenesis Mytilus galloprovincialis Crassostrea gigas Bivalves RNAi |
description |
Small non-coding RNAs include powerful regulators of gene expression, transposon mobility and virus activity. Among the various categories, mature microRNAs (miRNAs) guide the translational repression and decay of several targeted mRNAs. The biogenesis of miRNAs depends on few gene products, essentially conserved from basal to higher metazoans, whose protein domains allow specific interactions with dsRNA. Here, we report the identification of key genes responsible of the miRNA biogenesis in 32 bivalves, with particular attention to the aquaculture species Mytilus galloprovincialis and Crassostrea gigas. In detail, we have identified and phylogenetically compared eight evolutionary conserved proteins: DROSHA, DGCR8, EXP5, RAN, DICER TARBP2, AGO and PIWI. In mussels, we recognized several other proteins participating in the miRNA biogenesis or in the subsequent RNA silencing. According to digital expression analysis, these genes display low and not inducible expression levels in adult mussels and oysters whereas they are considerably expressed during development. As miRNAs play an important role also in the antiviral responses, knowledge on their production and regulative effects can shed light on essential molecular processes and provide new hints for disease prevention in bivalves. |
author2 |
Rosani, Umberto Pallavicini, A Venier, Paola |
format |
Article in Journal/Newspaper |
author |
ROSANI, UMBERTO VENIER, PAOLA Pallavicini A |
author_facet |
ROSANI, UMBERTO VENIER, PAOLA Pallavicini A |
author_sort |
ROSANI, UMBERTO |
title |
The miRNA biogenesis in marine bivalves |
title_short |
The miRNA biogenesis in marine bivalves |
title_full |
The miRNA biogenesis in marine bivalves |
title_fullStr |
The miRNA biogenesis in marine bivalves |
title_full_unstemmed |
The miRNA biogenesis in marine bivalves |
title_sort |
mirna biogenesis in marine bivalves |
publisher |
PEERJ INC (LONDON, ENGLAND) |
publishDate |
2016 |
url |
http://hdl.handle.net/11577/3181948 https://doi.org/10.7717/peerj.1763 |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/26989613 info:eu-repo/semantics/altIdentifier/wos/WOS:000371663100001 volume:4 firstpage:1 lastpage:25 numberofpages:25 journal:PEERJ http://hdl.handle.net/11577/3181948 doi:10.7717/peerj.1763 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84963967637 |
op_doi |
https://doi.org/10.7717/peerj.1763 |
container_title |
PeerJ |
container_volume |
4 |
container_start_page |
e1763 |
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1796941043001720832 |