Changes in the gene expression profiles of the brains of male European eels (Anguilla anguilla) during sexual maturation
Background The vertebrate brain plays a critical role in the regulation of sexual maturation and reproduction by integrating environmental information with developmental and endocrine status. The European eel Anguilla anguilla is an important species in which to better understand the neuroendocrine...
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BIOMED CENTRAL LTD, 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
2014
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Online Access: | http://hdl.handle.net/11577/2928099 https://doi.org/10.1186/1471-2164-15-799 |
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ftunivpadovairis:oai:www.research.unipd.it:11577/2928099 2024-04-21T07:45:35+00:00 Changes in the gene expression profiles of the brains of male European eels (Anguilla anguilla) during sexual maturation Allison M. Churcher Peter C. Hubbard Rute ST Martins Jo?o L. Saraiva Mar Huertas Adelino VM Can?rio PUJOLAR CASTANER, JOSE' MARTIN MILAN, MASSIMO BARGELLONI, LUCA PATARNELLO, TOMASO MARINO, ILARIA ANNA MARIA ZANE, LORENZO Allison M., Churcher PUJOLAR CASTANER, JOSE' MARTIN Milan, Massimo Peter C., Hubbard Rute ST, Martin Jo?o L., Saraiva Mar, Huerta Bargelloni, Luca Patarnello, Tomaso Marino, ILARIA ANNA MARIA Zane, Lorenzo Adelino VM, Can?rio 2014 ELETTRONICO http://hdl.handle.net/11577/2928099 https://doi.org/10.1186/1471-2164-15-799 eng eng BIOMED CENTRAL LTD, 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND info:eu-repo/semantics/altIdentifier/pmid/25230743 info:eu-repo/semantics/altIdentifier/wos/WOS:000341891400001 volume:15 firstpage:799 journal:BMC GENOMICS http://hdl.handle.net/11577/2928099 doi:10.1186/1471-2164-15-799 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84907434317 info:eu-repo/semantics/article 2014 ftunivpadovairis https://doi.org/10.1186/1471-2164-15-799 2024-03-28T01:45:37Z Background The vertebrate brain plays a critical role in the regulation of sexual maturation and reproduction by integrating environmental information with developmental and endocrine status. The European eel Anguilla anguilla is an important species in which to better understand the neuroendocrine factors that control reproduction because it is an endangered species, has a complex life cycle that includes two extreme long distance migrations with both freshwater and seawater stages and because it occupies a key position within the teleost phylogeny. At present, mature eels have never been caught in the wild and little is known about most aspects of reproduction in A. anguilla. The goal of this study was to identify genes that may be involved in sexual maturation in experimentally matured eels. For this, we used microarrays to compare the gene expression profiles of sexually mature to immature males. Results Using a false discovery rate of 0.05, a total of 1,497 differentially expressed genes were identified. Of this set, 991 were expressed at higher levels in brains (forebrain and midbrain) of mature males while 506 were expressed at lower levels relative to brains of immature males. The set of up-regulated genes includes genes involved in neuroendocrine processes, cell-cell signaling, neurogenesis and development. Interestingly, while genes involved in immune system function were down-regulated in the brains of mature males, changes in the expression levels of several receptors and channels were observed suggesting that some rewiring is occurring in the brain at sexual maturity. Conclusions This study shows that the brains of eels undergo major changes at the molecular level at sexual maturity that may include re-organization at the cellular level. Here, we have defined a set of genes that help to understand the molecular mechanisms controlling reproduction in eels. Some of these genes have previously described functions while many others have roles that have yet to be characterized in a reproductive context. ... Article in Journal/Newspaper Anguilla anguilla European eel Padua Research Archive (IRIS - Università degli Studi di Padova) BMC Genomics 15 1 799 |
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Open Polar |
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Padua Research Archive (IRIS - Università degli Studi di Padova) |
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ftunivpadovairis |
language |
English |
description |
Background The vertebrate brain plays a critical role in the regulation of sexual maturation and reproduction by integrating environmental information with developmental and endocrine status. The European eel Anguilla anguilla is an important species in which to better understand the neuroendocrine factors that control reproduction because it is an endangered species, has a complex life cycle that includes two extreme long distance migrations with both freshwater and seawater stages and because it occupies a key position within the teleost phylogeny. At present, mature eels have never been caught in the wild and little is known about most aspects of reproduction in A. anguilla. The goal of this study was to identify genes that may be involved in sexual maturation in experimentally matured eels. For this, we used microarrays to compare the gene expression profiles of sexually mature to immature males. Results Using a false discovery rate of 0.05, a total of 1,497 differentially expressed genes were identified. Of this set, 991 were expressed at higher levels in brains (forebrain and midbrain) of mature males while 506 were expressed at lower levels relative to brains of immature males. The set of up-regulated genes includes genes involved in neuroendocrine processes, cell-cell signaling, neurogenesis and development. Interestingly, while genes involved in immune system function were down-regulated in the brains of mature males, changes in the expression levels of several receptors and channels were observed suggesting that some rewiring is occurring in the brain at sexual maturity. Conclusions This study shows that the brains of eels undergo major changes at the molecular level at sexual maturity that may include re-organization at the cellular level. Here, we have defined a set of genes that help to understand the molecular mechanisms controlling reproduction in eels. Some of these genes have previously described functions while many others have roles that have yet to be characterized in a reproductive context. ... |
author2 |
Allison M., Churcher PUJOLAR CASTANER, JOSE' MARTIN Milan, Massimo Peter C., Hubbard Rute ST, Martin Jo?o L., Saraiva Mar, Huerta Bargelloni, Luca Patarnello, Tomaso Marino, ILARIA ANNA MARIA Zane, Lorenzo Adelino VM, Can?rio |
format |
Article in Journal/Newspaper |
author |
Allison M. Churcher Peter C. Hubbard Rute ST Martins Jo?o L. Saraiva Mar Huertas Adelino VM Can?rio PUJOLAR CASTANER, JOSE' MARTIN MILAN, MASSIMO BARGELLONI, LUCA PATARNELLO, TOMASO MARINO, ILARIA ANNA MARIA ZANE, LORENZO |
spellingShingle |
Allison M. Churcher Peter C. Hubbard Rute ST Martins Jo?o L. Saraiva Mar Huertas Adelino VM Can?rio PUJOLAR CASTANER, JOSE' MARTIN MILAN, MASSIMO BARGELLONI, LUCA PATARNELLO, TOMASO MARINO, ILARIA ANNA MARIA ZANE, LORENZO Changes in the gene expression profiles of the brains of male European eels (Anguilla anguilla) during sexual maturation |
author_facet |
Allison M. Churcher Peter C. Hubbard Rute ST Martins Jo?o L. Saraiva Mar Huertas Adelino VM Can?rio PUJOLAR CASTANER, JOSE' MARTIN MILAN, MASSIMO BARGELLONI, LUCA PATARNELLO, TOMASO MARINO, ILARIA ANNA MARIA ZANE, LORENZO |
author_sort |
Allison M. Churcher |
title |
Changes in the gene expression profiles of the brains of male European eels (Anguilla anguilla) during sexual maturation |
title_short |
Changes in the gene expression profiles of the brains of male European eels (Anguilla anguilla) during sexual maturation |
title_full |
Changes in the gene expression profiles of the brains of male European eels (Anguilla anguilla) during sexual maturation |
title_fullStr |
Changes in the gene expression profiles of the brains of male European eels (Anguilla anguilla) during sexual maturation |
title_full_unstemmed |
Changes in the gene expression profiles of the brains of male European eels (Anguilla anguilla) during sexual maturation |
title_sort |
changes in the gene expression profiles of the brains of male european eels (anguilla anguilla) during sexual maturation |
publisher |
BIOMED CENTRAL LTD, 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND |
publishDate |
2014 |
url |
http://hdl.handle.net/11577/2928099 https://doi.org/10.1186/1471-2164-15-799 |
genre |
Anguilla anguilla European eel |
genre_facet |
Anguilla anguilla European eel |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/25230743 info:eu-repo/semantics/altIdentifier/wos/WOS:000341891400001 volume:15 firstpage:799 journal:BMC GENOMICS http://hdl.handle.net/11577/2928099 doi:10.1186/1471-2164-15-799 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84907434317 |
op_doi |
https://doi.org/10.1186/1471-2164-15-799 |
container_title |
BMC Genomics |
container_volume |
15 |
container_issue |
1 |
container_start_page |
799 |
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1796940835591290880 |