Chemoenzymatic preparation of optically active secondary amines: a new efficient route to enantiomerically pure indolines

• Published in: Tetrahedron: Asymmetry
• Main Authors: Gotor Fernández, Vicente, Fernández Torres, Pedro, Gotor Santamaría, Vicente Miguel
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2020
• Subjects: Cierva; Antarc*; Antarctica
• Online Access: http://hdl.handle.net/10651/54880; https://doi.org/10.1016/j.tetasy.2006.08.012

An efficient chemoenzymatic route for the synthesis of optically active substituted indolines has been developed. Different lipases have been tested in the alkoxycarbonylation of these secondary amines, Candida antarctica lipase A (CAL-A) was found to be the best biocatalyst for 2-substituted-indoli...