Lobophorin K, a new natural product with cytotoxic activity produced by Streptomyces sp. M-207 associated with the deep-sea coral Lophelia pertusa

• Published in: Marine Drugs
• Main Authors: Fernández Braña, Alfredo Javier, Sarmiento Vizcaíno, Aida, Osset, Miguel, Pérez Victoria, Ignacio, Martín, Jesús, Pedro, Nuria de, Cruz, Mercedes de la, Díaz, Caridad, Vicente, Francisca, Reyes, Fernando, García Díaz, Luis Arsenio, Blanco Blanco, María Gloria
• Format: Article in Journal/Newspaper
• Language: English
• Published: MDPI 2018
• Subjects: lobophorins; spirotetronate antibiotic; Streptomyces; antitumor; Acuña; Lophelia pertusa
• Online Access: http://hdl.handle.net/10651/49088

The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Avilés Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus. The authors are grateful to José Luis Acuña for his invitation to the BIOCANT3 oceanographic expedition (DOSMARES) where Streptomyces sp. M-207 was isolated. This study was financially supported by the Universidad de Oviedo (UNOV-11-MA-02) and Gobierno del Principado de Asturias (SV-PA-13-ECOEMP-62). The polarimeter, IR, and NMR equipment used in this work were acquired via grants for scientific and technological infrastructures from the Ministerio de Ciencia e Innovación (Grants No. PCT-010000-2010-4 (NMR), INP-2011-0016-PCT-010000 ACT6 (polarimeter and IR)). This is a contribution of the Asturias Marine Observatory.