The association of PCOS and hypertensive disorders of pregnancy:a community based approach
Abstract. Objective. To investigate the prevalence of hypertensive disorders of pregnancy (HDP), and the respective roles of PCOS, obesity, lifelong weight gain (WG) and hyperandrogenemia in the disease development by age 46. Methods. The Northern Finland Birth Cohort 1966, with follow-up at ages 14...
Main Author: | |
---|---|
Format: | Other/Unknown Material |
Language: | English |
Published: |
University of Oulu
2020
|
Subjects: | |
Online Access: | http://jultika.oulu.fi/Record/nbnfioulu-202002181155 |
id |
ftunivoulu:oai:oulu.fi:nbnfioulu-202002181155 |
---|---|
record_format |
openpolar |
spelling |
ftunivoulu:oai:oulu.fi:nbnfioulu-202002181155 2023-07-30T04:05:50+02:00 The association of PCOS and hypertensive disorders of pregnancy:a community based approach Rantakallio, J. (Juhani) 2020-02-14 application/pdf http://jultika.oulu.fi/Record/nbnfioulu-202002181155 eng eng University of Oulu info:eu-repo/semantics/openAccess © Juhani Rantakallio, 2020 info:eu-repo/semantics/other info:eu-repo/semantics/publishedVersion 2020 ftunivoulu 2023-07-08T19:58:36Z Abstract. Objective. To investigate the prevalence of hypertensive disorders of pregnancy (HDP), and the respective roles of PCOS, obesity, lifelong weight gain (WG) and hyperandrogenemia in the disease development by age 46. Methods. The Northern Finland Birth Cohort 1966, with follow-up at ages 14, 31 and 46, including women with (n=408) and without (n=3373) HDP diagnosis. HDP diagnosis was combined from the questionnaire data at age 46, hospital discharge records and Finnish Medical Birth Registers. Women with both oligo-amenorrhea and hirsutism at age 31 or with PCOS diagnosis by age 46 (n=279) were compared with the women without PCOS (n=1577). Results. Women with PCOS had an increased HDP risk (odds ratio [OR]=1.56 [95%CI:1.03–2.37]), but the association disappeared after adjusting for BMI at age 31. The risk for HDP was not increased among normal weight PCOS women. The increase of BMI (kg/m²) from age 14 to 31 was significantly greater in both PCOS (median (interquartile range): 5.94(3.69;11.1), p<0.001) and non-PCOS (4.89(3.21;7.57), p<0.001) women with HDP and also in PCOS women without HDP (4.59(2.40;7.54), p=0.009) compared to non-PCOS without HDP. Among women with PCOS, BMI increase was greater in women with than without HDP (5.94(3.69;11.1) vs 4.59(2.40;7.54), p=0.015). Hyperandrogenemia at ages 31 or 46 did not associate with HDP (OR=1.44 [95%CI: 0.98–2.11]). Conclusion: Obesity and weight gain from adolescence to age 46, but not PCOS per se or hyperandrogenemia, were associated with an increased risk of HDP. There was a strong synergistic association of PCOS and obesity regarding HDP risk. Other/Unknown Material Northern Finland Jultika - University of Oulu repository |
institution |
Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
description |
Abstract. Objective. To investigate the prevalence of hypertensive disorders of pregnancy (HDP), and the respective roles of PCOS, obesity, lifelong weight gain (WG) and hyperandrogenemia in the disease development by age 46. Methods. The Northern Finland Birth Cohort 1966, with follow-up at ages 14, 31 and 46, including women with (n=408) and without (n=3373) HDP diagnosis. HDP diagnosis was combined from the questionnaire data at age 46, hospital discharge records and Finnish Medical Birth Registers. Women with both oligo-amenorrhea and hirsutism at age 31 or with PCOS diagnosis by age 46 (n=279) were compared with the women without PCOS (n=1577). Results. Women with PCOS had an increased HDP risk (odds ratio [OR]=1.56 [95%CI:1.03–2.37]), but the association disappeared after adjusting for BMI at age 31. The risk for HDP was not increased among normal weight PCOS women. The increase of BMI (kg/m²) from age 14 to 31 was significantly greater in both PCOS (median (interquartile range): 5.94(3.69;11.1), p<0.001) and non-PCOS (4.89(3.21;7.57), p<0.001) women with HDP and also in PCOS women without HDP (4.59(2.40;7.54), p=0.009) compared to non-PCOS without HDP. Among women with PCOS, BMI increase was greater in women with than without HDP (5.94(3.69;11.1) vs 4.59(2.40;7.54), p=0.015). Hyperandrogenemia at ages 31 or 46 did not associate with HDP (OR=1.44 [95%CI: 0.98–2.11]). Conclusion: Obesity and weight gain from adolescence to age 46, but not PCOS per se or hyperandrogenemia, were associated with an increased risk of HDP. There was a strong synergistic association of PCOS and obesity regarding HDP risk. |
format |
Other/Unknown Material |
author |
Rantakallio, J. (Juhani) |
spellingShingle |
Rantakallio, J. (Juhani) The association of PCOS and hypertensive disorders of pregnancy:a community based approach |
author_facet |
Rantakallio, J. (Juhani) |
author_sort |
Rantakallio, J. (Juhani) |
title |
The association of PCOS and hypertensive disorders of pregnancy:a community based approach |
title_short |
The association of PCOS and hypertensive disorders of pregnancy:a community based approach |
title_full |
The association of PCOS and hypertensive disorders of pregnancy:a community based approach |
title_fullStr |
The association of PCOS and hypertensive disorders of pregnancy:a community based approach |
title_full_unstemmed |
The association of PCOS and hypertensive disorders of pregnancy:a community based approach |
title_sort |
association of pcos and hypertensive disorders of pregnancy:a community based approach |
publisher |
University of Oulu |
publishDate |
2020 |
url |
http://jultika.oulu.fi/Record/nbnfioulu-202002181155 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_rights |
info:eu-repo/semantics/openAccess © Juhani Rantakallio, 2020 |
_version_ |
1772818070557949952 |