Low and high serum IgG associates with respiratory infections in a young and working age population
Abstract Background: We investigated health consequences and genetic properties associated with serum IgG concentration in a young and working age general population. Methods: Northern Finland Birth Cohort 1966 (NFBC1966, n = 12,231) health data have been collected from birth to 52 years of age. Rel...
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ftunivoulu:oai:oulu.fi:nbnfi-fe20230929137799 2023-10-29T02:38:55+01:00 Low and high serum IgG associates with respiratory infections in a young and working age population Holma, P. (Pia) Pesonen, P. (Paula) Karjalainen, M. K. (Minna K.) Järvelin, M.-R. (Marjo-Riitta) Väyrynen, S. (Sara) Sliz, E. (Eeva) Heikkilä, A. (Anni) Seppänen, M. R. (Mikko R. J.) Kettunen, J. (Johannes) Auvinen, J. (Juha) Hautala, T. (Timo) 2023 application/pdf http://urn.fi/urn:nbn:fi-fe20230929137799 eng eng Elsevier info:eu-repo/semantics/openAccess © 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). https://creativecommons.org/licenses/by-nc-nd/4.0/ Adaptive immunity Birth cohort Immunoglobulins Pneumonia Respiratory tract infections Smoking info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2023 ftunivoulu 2023-10-04T23:00:02Z Abstract Background: We investigated health consequences and genetic properties associated with serum IgG concentration in a young and working age general population. Methods: Northern Finland Birth Cohort 1966 (NFBC1966, n = 12,231) health data have been collected from birth to 52 years of age. Relationships between life-long health events, medications, chronic conditions, lifestyle, and serum IgG concentration measured at age 46 years (n = 5430) were analysed. Regulatory mechanisms of serum IgG concentration were considered. Findings: Smoking and genetic variation (FCGR2B and TNFRSF13B) were the most important determinants of serum IgG concentration. Laboratory findings suggestive of common variable immunodeficiency (CVID) were 10-fold higher compared to previous reports (73.7 per 100,000 vs 0.6–6.9 per 100,000). Low IgG was associated with antibiotic use (relative risk 1.285, 95% CI 1.001–1.648; p = 0.049) and sinus surgery (relative risk 2.257, 95% CI 1.163–4.379; p = 0.016). High serum IgG was associated with at least one pneumonia episode (relative risk 1.737, 95% CI 1.032–2.922; p = 0.038) and with total number of pneumonia episodes (relative risk 2.167, 95% CI 1.443–3.254; p < 0.001). Interpretation: CVID-like laboratory findings are surprisingly common in our unselected study population. Any deviation of serum IgG from normal values can be harmful; both low and high serum IgG may indicate immunological insufficiency. Critical evaluation of clinical presentation must accompany immunological laboratory parameters. Funding: Oulu University Hospital VTR, CSL Behring, Foundation for Pediatric Research. Article in Journal/Newspaper Northern Finland Jultika - University of Oulu repository |
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Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
Adaptive immunity Birth cohort Immunoglobulins Pneumonia Respiratory tract infections Smoking |
spellingShingle |
Adaptive immunity Birth cohort Immunoglobulins Pneumonia Respiratory tract infections Smoking Holma, P. (Pia) Pesonen, P. (Paula) Karjalainen, M. K. (Minna K.) Järvelin, M.-R. (Marjo-Riitta) Väyrynen, S. (Sara) Sliz, E. (Eeva) Heikkilä, A. (Anni) Seppänen, M. R. (Mikko R. J.) Kettunen, J. (Johannes) Auvinen, J. (Juha) Hautala, T. (Timo) Low and high serum IgG associates with respiratory infections in a young and working age population |
topic_facet |
Adaptive immunity Birth cohort Immunoglobulins Pneumonia Respiratory tract infections Smoking |
description |
Abstract Background: We investigated health consequences and genetic properties associated with serum IgG concentration in a young and working age general population. Methods: Northern Finland Birth Cohort 1966 (NFBC1966, n = 12,231) health data have been collected from birth to 52 years of age. Relationships between life-long health events, medications, chronic conditions, lifestyle, and serum IgG concentration measured at age 46 years (n = 5430) were analysed. Regulatory mechanisms of serum IgG concentration were considered. Findings: Smoking and genetic variation (FCGR2B and TNFRSF13B) were the most important determinants of serum IgG concentration. Laboratory findings suggestive of common variable immunodeficiency (CVID) were 10-fold higher compared to previous reports (73.7 per 100,000 vs 0.6–6.9 per 100,000). Low IgG was associated with antibiotic use (relative risk 1.285, 95% CI 1.001–1.648; p = 0.049) and sinus surgery (relative risk 2.257, 95% CI 1.163–4.379; p = 0.016). High serum IgG was associated with at least one pneumonia episode (relative risk 1.737, 95% CI 1.032–2.922; p = 0.038) and with total number of pneumonia episodes (relative risk 2.167, 95% CI 1.443–3.254; p < 0.001). Interpretation: CVID-like laboratory findings are surprisingly common in our unselected study population. Any deviation of serum IgG from normal values can be harmful; both low and high serum IgG may indicate immunological insufficiency. Critical evaluation of clinical presentation must accompany immunological laboratory parameters. Funding: Oulu University Hospital VTR, CSL Behring, Foundation for Pediatric Research. |
format |
Article in Journal/Newspaper |
author |
Holma, P. (Pia) Pesonen, P. (Paula) Karjalainen, M. K. (Minna K.) Järvelin, M.-R. (Marjo-Riitta) Väyrynen, S. (Sara) Sliz, E. (Eeva) Heikkilä, A. (Anni) Seppänen, M. R. (Mikko R. J.) Kettunen, J. (Johannes) Auvinen, J. (Juha) Hautala, T. (Timo) |
author_facet |
Holma, P. (Pia) Pesonen, P. (Paula) Karjalainen, M. K. (Minna K.) Järvelin, M.-R. (Marjo-Riitta) Väyrynen, S. (Sara) Sliz, E. (Eeva) Heikkilä, A. (Anni) Seppänen, M. R. (Mikko R. J.) Kettunen, J. (Johannes) Auvinen, J. (Juha) Hautala, T. (Timo) |
author_sort |
Holma, P. (Pia) |
title |
Low and high serum IgG associates with respiratory infections in a young and working age population |
title_short |
Low and high serum IgG associates with respiratory infections in a young and working age population |
title_full |
Low and high serum IgG associates with respiratory infections in a young and working age population |
title_fullStr |
Low and high serum IgG associates with respiratory infections in a young and working age population |
title_full_unstemmed |
Low and high serum IgG associates with respiratory infections in a young and working age population |
title_sort |
low and high serum igg associates with respiratory infections in a young and working age population |
publisher |
Elsevier |
publishDate |
2023 |
url |
http://urn.fi/urn:nbn:fi-fe20230929137799 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_rights |
info:eu-repo/semantics/openAccess © 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). https://creativecommons.org/licenses/by-nc-nd/4.0/ |
_version_ |
1781065356770541568 |