Compositional association of 24-h movement behavior with incident major adverse cardiac events and all-cause mortality
Abstract Cardiovascular disease (CVD) causes a high disease burden. Physical activity (PA) reduces CVD morbidity and mortality. We aimed to determine the relationship between the composition of moderate-to-vigorous PA (MVPA), light PA (LPA), sedentary behavior (SB), and sleep during midlife to the i...
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ftunivoulu:oai:oulu.fi:nbnfi-fe2023081495559 2023-09-05T13:21:56+02:00 Compositional association of 24-h movement behavior with incident major adverse cardiac events and all-cause mortality Niemelä, M. (Maisa) Kiviniemi, A. (Antti) Ikäheimo, T. M. (Tiina M.) Tulppo, M. (Mikko) Korpelainen, R. (Raija) Jämsä, T. (Timo) Farrahi, V. (Vahid) 2023 application/pdf http://urn.fi/urn:nbn:fi-fe2023081495559 eng eng John Wiley & Sons info:eu-repo/semantics/openAccess © 2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ cardiovascular disease compositional data analysis physical activity population-based cohort sedentary time info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2023 ftunivoulu 2023-08-16T22:59:21Z Abstract Cardiovascular disease (CVD) causes a high disease burden. Physical activity (PA) reduces CVD morbidity and mortality. We aimed to determine the relationship between the composition of moderate-to-vigorous PA (MVPA), light PA (LPA), sedentary behavior (SB), and sleep during midlife to the incidence of major adverse cardiac events (MACE) and all-cause mortality at a 7-year follow-up. The study population consisted of Northern Finland Birth Cohort 1966 members who participated in the 46-year follow-up in 2012 and were free of MACE (N = 4147). Time spent in MVPA, LPA, and SB was determined from accelerometer data. Sleep time was self-reported. Hospital visits and deaths were obtained from national registers. Participants were followed until December 31, 2019, or first MACE occurrence (acute myocardial infarction, unstable angina pectoris, stroke, hospitalization due to heart failure, or death due to CVD), death from another cause, or censoring. Cox proportional hazards model was used to estimate hazard ratios of MACE incidence and all-cause mortality. Isotemporal time reallocations were used to demonstrate the dose–response association between time spent in behaviors and outcome. The 24-h time composition was significantly associated with incident MACE and all-cause mortality. More time in MVPA relative to other behaviors was associated with a lower risk of events. Isotemporal time reallocations indicated that the greatest risk reduction occurred when MVPA replaced sleep. Higher MVPA associates with a reduced risk of incident MACE and all-cause mortality after accounting for the 24-h movement composition and confounders. Regular engagement in MVPA should be encouraged in midlife. Article in Journal/Newspaper Northern Finland Jultika - University of Oulu repository Mace ENVELOPE(155.883,155.883,-81.417,-81.417) |
institution |
Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
cardiovascular disease compositional data analysis physical activity population-based cohort sedentary time |
spellingShingle |
cardiovascular disease compositional data analysis physical activity population-based cohort sedentary time Niemelä, M. (Maisa) Kiviniemi, A. (Antti) Ikäheimo, T. M. (Tiina M.) Tulppo, M. (Mikko) Korpelainen, R. (Raija) Jämsä, T. (Timo) Farrahi, V. (Vahid) Compositional association of 24-h movement behavior with incident major adverse cardiac events and all-cause mortality |
topic_facet |
cardiovascular disease compositional data analysis physical activity population-based cohort sedentary time |
description |
Abstract Cardiovascular disease (CVD) causes a high disease burden. Physical activity (PA) reduces CVD morbidity and mortality. We aimed to determine the relationship between the composition of moderate-to-vigorous PA (MVPA), light PA (LPA), sedentary behavior (SB), and sleep during midlife to the incidence of major adverse cardiac events (MACE) and all-cause mortality at a 7-year follow-up. The study population consisted of Northern Finland Birth Cohort 1966 members who participated in the 46-year follow-up in 2012 and were free of MACE (N = 4147). Time spent in MVPA, LPA, and SB was determined from accelerometer data. Sleep time was self-reported. Hospital visits and deaths were obtained from national registers. Participants were followed until December 31, 2019, or first MACE occurrence (acute myocardial infarction, unstable angina pectoris, stroke, hospitalization due to heart failure, or death due to CVD), death from another cause, or censoring. Cox proportional hazards model was used to estimate hazard ratios of MACE incidence and all-cause mortality. Isotemporal time reallocations were used to demonstrate the dose–response association between time spent in behaviors and outcome. The 24-h time composition was significantly associated with incident MACE and all-cause mortality. More time in MVPA relative to other behaviors was associated with a lower risk of events. Isotemporal time reallocations indicated that the greatest risk reduction occurred when MVPA replaced sleep. Higher MVPA associates with a reduced risk of incident MACE and all-cause mortality after accounting for the 24-h movement composition and confounders. Regular engagement in MVPA should be encouraged in midlife. |
format |
Article in Journal/Newspaper |
author |
Niemelä, M. (Maisa) Kiviniemi, A. (Antti) Ikäheimo, T. M. (Tiina M.) Tulppo, M. (Mikko) Korpelainen, R. (Raija) Jämsä, T. (Timo) Farrahi, V. (Vahid) |
author_facet |
Niemelä, M. (Maisa) Kiviniemi, A. (Antti) Ikäheimo, T. M. (Tiina M.) Tulppo, M. (Mikko) Korpelainen, R. (Raija) Jämsä, T. (Timo) Farrahi, V. (Vahid) |
author_sort |
Niemelä, M. (Maisa) |
title |
Compositional association of 24-h movement behavior with incident major adverse cardiac events and all-cause mortality |
title_short |
Compositional association of 24-h movement behavior with incident major adverse cardiac events and all-cause mortality |
title_full |
Compositional association of 24-h movement behavior with incident major adverse cardiac events and all-cause mortality |
title_fullStr |
Compositional association of 24-h movement behavior with incident major adverse cardiac events and all-cause mortality |
title_full_unstemmed |
Compositional association of 24-h movement behavior with incident major adverse cardiac events and all-cause mortality |
title_sort |
compositional association of 24-h movement behavior with incident major adverse cardiac events and all-cause mortality |
publisher |
John Wiley & Sons |
publishDate |
2023 |
url |
http://urn.fi/urn:nbn:fi-fe2023081495559 |
long_lat |
ENVELOPE(155.883,155.883,-81.417,-81.417) |
geographic |
Mace |
geographic_facet |
Mace |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_rights |
info:eu-repo/semantics/openAccess © 2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ |
_version_ |
1776202494117937152 |