Body mass index in the middle-aged offspring of parents with severe mental illness
Abstract Background: People with severe mental illness (SMI) have an elevated risk of obesity but the causes and mechanisms are unclear. We explored the familial association between parental SMI and body mass index (BMI) in middle-aged offspring. Our objective was to determine if the offspring of ei...
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ftunivoulu:oai:oulu.fi:nbnfi-fe2023062759342 2023-07-30T04:05:49+02:00 Body mass index in the middle-aged offspring of parents with severe mental illness Protsenko, M. (Maria) Kerkelä, M. (Martta) Miettunen, J. (Jouko) Auvinen, J. (Juha) Järvelin, M.-R. (Marjo-Riitta) Jones, P. B. (Peter B.) Gissler, M. (Mika) Veijola, J. (Juha) 2022 application/pdf http://urn.fi/urn:nbn:fi-fe2023062759342 eng eng Cambridge University Press info:eu-repo/semantics/openAccess © The Author(s), 2022. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. https://creativecommons.org/licenses/by/4.0/ bipolar disorder body mass index cohort study depression schizophrenia info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2022 ftunivoulu 2023-07-08T20:02:05Z Abstract Background: People with severe mental illness (SMI) have an elevated risk of obesity but the causes and mechanisms are unclear. We explored the familial association between parental SMI and body mass index (BMI) in middle-aged offspring. Our objective was to determine if the offspring of either parent with SMI have an increased risk for obesity. Methods: The Northern Finland Birth Cohort 1966 is a cohort study of offspring with expected date of birth in 1966. The data include originally 12 068 mothers and 12 231 children from the provinces of Lapland and Oulu in Finland. The final study sample included 5050 middle-aged offspring. Parental SMI was used as exposure in the study. BMI measured at the age of 46 years was used as a primary outcome. Results: Risk for obesity was elevated in the offspring of mothers with SMI [overweight: adjusted odds ratio (OR) 1.93 (1.29–2.90), obese class I: 1.97 (1.20–3.25), obese classes II–III: 2.98 (1.67–5.33)]. For the offspring of either parent with SMI, statistically significant results were found in obese class I and obese classes II–III [overweight: adjusted OR 1.21 (0.94–1.54), obese class I: 1.52 (1.03–1.08), obese classes II–III: 1.53 (1.01–2.32)]. Conclusions: We found an elevated risk of obesity in the middle-aged offspring of either parent with SMI, especially in the offspring of mothers with SMI. Thus, there might be a common familial pathway leading to the co-occurrence of obesity and SMI. Article in Journal/Newspaper Northern Finland Lapland Jultika - University of Oulu repository |
institution |
Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
bipolar disorder body mass index cohort study depression schizophrenia |
spellingShingle |
bipolar disorder body mass index cohort study depression schizophrenia Protsenko, M. (Maria) Kerkelä, M. (Martta) Miettunen, J. (Jouko) Auvinen, J. (Juha) Järvelin, M.-R. (Marjo-Riitta) Jones, P. B. (Peter B.) Gissler, M. (Mika) Veijola, J. (Juha) Body mass index in the middle-aged offspring of parents with severe mental illness |
topic_facet |
bipolar disorder body mass index cohort study depression schizophrenia |
description |
Abstract Background: People with severe mental illness (SMI) have an elevated risk of obesity but the causes and mechanisms are unclear. We explored the familial association between parental SMI and body mass index (BMI) in middle-aged offspring. Our objective was to determine if the offspring of either parent with SMI have an increased risk for obesity. Methods: The Northern Finland Birth Cohort 1966 is a cohort study of offspring with expected date of birth in 1966. The data include originally 12 068 mothers and 12 231 children from the provinces of Lapland and Oulu in Finland. The final study sample included 5050 middle-aged offspring. Parental SMI was used as exposure in the study. BMI measured at the age of 46 years was used as a primary outcome. Results: Risk for obesity was elevated in the offspring of mothers with SMI [overweight: adjusted odds ratio (OR) 1.93 (1.29–2.90), obese class I: 1.97 (1.20–3.25), obese classes II–III: 2.98 (1.67–5.33)]. For the offspring of either parent with SMI, statistically significant results were found in obese class I and obese classes II–III [overweight: adjusted OR 1.21 (0.94–1.54), obese class I: 1.52 (1.03–1.08), obese classes II–III: 1.53 (1.01–2.32)]. Conclusions: We found an elevated risk of obesity in the middle-aged offspring of either parent with SMI, especially in the offspring of mothers with SMI. Thus, there might be a common familial pathway leading to the co-occurrence of obesity and SMI. |
format |
Article in Journal/Newspaper |
author |
Protsenko, M. (Maria) Kerkelä, M. (Martta) Miettunen, J. (Jouko) Auvinen, J. (Juha) Järvelin, M.-R. (Marjo-Riitta) Jones, P. B. (Peter B.) Gissler, M. (Mika) Veijola, J. (Juha) |
author_facet |
Protsenko, M. (Maria) Kerkelä, M. (Martta) Miettunen, J. (Jouko) Auvinen, J. (Juha) Järvelin, M.-R. (Marjo-Riitta) Jones, P. B. (Peter B.) Gissler, M. (Mika) Veijola, J. (Juha) |
author_sort |
Protsenko, M. (Maria) |
title |
Body mass index in the middle-aged offspring of parents with severe mental illness |
title_short |
Body mass index in the middle-aged offspring of parents with severe mental illness |
title_full |
Body mass index in the middle-aged offspring of parents with severe mental illness |
title_fullStr |
Body mass index in the middle-aged offspring of parents with severe mental illness |
title_full_unstemmed |
Body mass index in the middle-aged offspring of parents with severe mental illness |
title_sort |
body mass index in the middle-aged offspring of parents with severe mental illness |
publisher |
Cambridge University Press |
publishDate |
2022 |
url |
http://urn.fi/urn:nbn:fi-fe2023062759342 |
genre |
Northern Finland Lapland |
genre_facet |
Northern Finland Lapland |
op_rights |
info:eu-repo/semantics/openAccess © The Author(s), 2022. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. https://creativecommons.org/licenses/by/4.0/ |
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1772818053933826048 |