Characteristics and predictors of off-label use of antipsychotics in general population sample
Abstract Objective: Increasing number of people have been prescribed antipsychotics (APs) off-label in recent decades. This study aimed to identify the characteristics and predictors of receiving prescription of antipsychotics off-label. Methods: The study sample was part of the Northern Finland Bir...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
John Wiley & Sons
2022
|
Subjects: | |
Online Access: | http://urn.fi/urn:nbn:fi-fe2023060552557 |
id |
ftunivoulu:oai:oulu.fi:nbnfi-fe2023060552557 |
---|---|
record_format |
openpolar |
spelling |
ftunivoulu:oai:oulu.fi:nbnfi-fe2023060552557 2023-07-30T04:05:50+02:00 Characteristics and predictors of off-label use of antipsychotics in general population sample Pirhonen, E. (Eero) Haapea, M. (Marianne) Rautio, N. (Nina) Nordström, T. (Tanja) Turpeinen, M. (Miia) Laatikainen, O. (Outi) Koponen, H. (Hannu) Silvan, J. (Jenni) Miettunen, J. (Jouko) Jääskeläinen, E. (Erika) 2022 application/pdf http://urn.fi/urn:nbn:fi-fe2023060552557 eng eng John Wiley & Sons info:eu-repo/semantics/openAccess © 2022 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. https://creativecommons.org/licenses/by-nc/4.0/ antipsychotic agent comorbidity mental disorders off-label use socioeconomic status info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2022 ftunivoulu 2023-07-08T20:01:57Z Abstract Objective: Increasing number of people have been prescribed antipsychotics (APs) off-label in recent decades. This study aimed to identify the characteristics and predictors of receiving prescription of antipsychotics off-label. Methods: The study sample was part of the Northern Finland Birth Cohort 1966 (n = 7071). Data included questionnaires and national register data. Information on prescribed medications was extracted from the national register. The sample was divided into three groups: Persons who had been prescribed APs off-label (n = 137), individuals with non-psychotic mental disorders without APs off label (n = 1478) and individuals who had been diagnosed with psychosis or bipolar disorder and who had been prescribed APs (n = 151). We compared sociodemographic, lifestyle and clinical characteristics between the off-label and the comparison groups using logistic regression. Results: The most common diagnoses in the off-label group were depression (n = 96, 70.1%) and anxiety (n = 55, 40.1%). Compared with individuals with non-psychotic mental disorders who were not prescribed APs off-label, individuals with prescribed off-label APs had a lower level of education, lower socioeconomic status, were less often married, had a higher level of somatic and psychiatric morbidity, were more often smokers and more often had a substance abuse disorder and heavy alcohol consumption. When comparing the off-label group to individuals with psychosis or bipolar disorder who used APs, there were less differences, though individuals with psychosis or bipolar disorder had more markers of morbidity and a lower level of education. Conclusions: Individuals who had been prescribed APs off label had a higher level of mental and somatic morbidity and poorer socioeconomic status than individuals with non-psychotic mental disorders who did not use APs. Article in Journal/Newspaper Northern Finland Jultika - University of Oulu repository |
institution |
Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
antipsychotic agent comorbidity mental disorders off-label use socioeconomic status |
spellingShingle |
antipsychotic agent comorbidity mental disorders off-label use socioeconomic status Pirhonen, E. (Eero) Haapea, M. (Marianne) Rautio, N. (Nina) Nordström, T. (Tanja) Turpeinen, M. (Miia) Laatikainen, O. (Outi) Koponen, H. (Hannu) Silvan, J. (Jenni) Miettunen, J. (Jouko) Jääskeläinen, E. (Erika) Characteristics and predictors of off-label use of antipsychotics in general population sample |
topic_facet |
antipsychotic agent comorbidity mental disorders off-label use socioeconomic status |
description |
Abstract Objective: Increasing number of people have been prescribed antipsychotics (APs) off-label in recent decades. This study aimed to identify the characteristics and predictors of receiving prescription of antipsychotics off-label. Methods: The study sample was part of the Northern Finland Birth Cohort 1966 (n = 7071). Data included questionnaires and national register data. Information on prescribed medications was extracted from the national register. The sample was divided into three groups: Persons who had been prescribed APs off-label (n = 137), individuals with non-psychotic mental disorders without APs off label (n = 1478) and individuals who had been diagnosed with psychosis or bipolar disorder and who had been prescribed APs (n = 151). We compared sociodemographic, lifestyle and clinical characteristics between the off-label and the comparison groups using logistic regression. Results: The most common diagnoses in the off-label group were depression (n = 96, 70.1%) and anxiety (n = 55, 40.1%). Compared with individuals with non-psychotic mental disorders who were not prescribed APs off-label, individuals with prescribed off-label APs had a lower level of education, lower socioeconomic status, were less often married, had a higher level of somatic and psychiatric morbidity, were more often smokers and more often had a substance abuse disorder and heavy alcohol consumption. When comparing the off-label group to individuals with psychosis or bipolar disorder who used APs, there were less differences, though individuals with psychosis or bipolar disorder had more markers of morbidity and a lower level of education. Conclusions: Individuals who had been prescribed APs off label had a higher level of mental and somatic morbidity and poorer socioeconomic status than individuals with non-psychotic mental disorders who did not use APs. |
format |
Article in Journal/Newspaper |
author |
Pirhonen, E. (Eero) Haapea, M. (Marianne) Rautio, N. (Nina) Nordström, T. (Tanja) Turpeinen, M. (Miia) Laatikainen, O. (Outi) Koponen, H. (Hannu) Silvan, J. (Jenni) Miettunen, J. (Jouko) Jääskeläinen, E. (Erika) |
author_facet |
Pirhonen, E. (Eero) Haapea, M. (Marianne) Rautio, N. (Nina) Nordström, T. (Tanja) Turpeinen, M. (Miia) Laatikainen, O. (Outi) Koponen, H. (Hannu) Silvan, J. (Jenni) Miettunen, J. (Jouko) Jääskeläinen, E. (Erika) |
author_sort |
Pirhonen, E. (Eero) |
title |
Characteristics and predictors of off-label use of antipsychotics in general population sample |
title_short |
Characteristics and predictors of off-label use of antipsychotics in general population sample |
title_full |
Characteristics and predictors of off-label use of antipsychotics in general population sample |
title_fullStr |
Characteristics and predictors of off-label use of antipsychotics in general population sample |
title_full_unstemmed |
Characteristics and predictors of off-label use of antipsychotics in general population sample |
title_sort |
characteristics and predictors of off-label use of antipsychotics in general population sample |
publisher |
John Wiley & Sons |
publishDate |
2022 |
url |
http://urn.fi/urn:nbn:fi-fe2023060552557 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_rights |
info:eu-repo/semantics/openAccess © 2022 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. https://creativecommons.org/licenses/by-nc/4.0/ |
_version_ |
1772818073556877312 |