Effects of gender and psychiatric comorbidity on the age of illness onset and the outcome of psychotic depression:a birth cohort study
Abstract Background: Psychotic depression (PD) is an under-researched disorder with severe symptoms and course of illness. Little is known about gender differences relating to this condition and possible variation of prognosis based on comorbid pathology. Our aim was to analyze the effects of gender...
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ftunivoulu:oai:oulu.fi:nbnfi-fe2021121761261 2023-07-30T04:05:50+02:00 Effects of gender and psychiatric comorbidity on the age of illness onset and the outcome of psychotic depression:a birth cohort study Nietola, M. (Miika) Nordström, T. (Tanja) Miettunen, J. (Jouko) Korkeila, J. (Jyrki) Jääskeläinen, E. (Erika) 2022 application/pdf http://urn.fi/urn:nbn:fi-fe2021121761261 eng eng Elsevier info:eu-repo/semantics/openAccess © 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). https://creativecommons.org/licenses/by/4.0/ Birth cohort Comorbidity Gender Outcom Prognosis Psychotic depression info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2022 ftunivoulu 2023-07-08T19:58:40Z Abstract Background: Psychotic depression (PD) is an under-researched disorder with severe symptoms and course of illness. Little is known about gender differences relating to this condition and possible variation of prognosis based on comorbid pathology. Our aim was to analyze the effects of gender and psychiatric comorbidities on the age of illness onset and on the outcome of psychotic depression. Methods: The study was carried out in the Northern Finland Birth Cohort 1966. We utilized register data to acquire information about lifetime psychiatric diagnoses, hospitalization, age of illness onset, rate of disability pensions and mortality. The PD group (n = 58) was defined based on a lifetime register diagnosis. We compared outcome variables in sub-groups based on gender and comorbid alcohol use or personality disorder. Results: The prevalence of comorbid personality disorders was 38% (22/58) and comorbid alcohol use disorders 41% (24/58). PD patients with a personality disorder diagnosis had an earlier onset age (p<0.01) and a higher mortality rate (p = 0.03). Male gender (p = 0.03), comorbid alcohol use disorder (p%lt;0.01) and personality disorder (p %lt; 0.01) were all associated with more psychiatric hospitalization. Comorbid alcohol use disorder was more common among men (males: 61%; females: 29%; p = 0.03). Limitations: National registers were the main source of diagnostic information. Conclusions: Gender and psychiatric comorbidity have significant implications for the course of illness in PD in naturalistic settings, which is an important message for all clinicians. More research into the heterogeneity of PD is needed in order to guide research and clinical practice. Article in Journal/Newspaper Northern Finland Jultika - University of Oulu repository |
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Jultika - University of Oulu repository |
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ftunivoulu |
language |
English |
topic |
Birth cohort Comorbidity Gender Outcom Prognosis Psychotic depression |
spellingShingle |
Birth cohort Comorbidity Gender Outcom Prognosis Psychotic depression Nietola, M. (Miika) Nordström, T. (Tanja) Miettunen, J. (Jouko) Korkeila, J. (Jyrki) Jääskeläinen, E. (Erika) Effects of gender and psychiatric comorbidity on the age of illness onset and the outcome of psychotic depression:a birth cohort study |
topic_facet |
Birth cohort Comorbidity Gender Outcom Prognosis Psychotic depression |
description |
Abstract Background: Psychotic depression (PD) is an under-researched disorder with severe symptoms and course of illness. Little is known about gender differences relating to this condition and possible variation of prognosis based on comorbid pathology. Our aim was to analyze the effects of gender and psychiatric comorbidities on the age of illness onset and on the outcome of psychotic depression. Methods: The study was carried out in the Northern Finland Birth Cohort 1966. We utilized register data to acquire information about lifetime psychiatric diagnoses, hospitalization, age of illness onset, rate of disability pensions and mortality. The PD group (n = 58) was defined based on a lifetime register diagnosis. We compared outcome variables in sub-groups based on gender and comorbid alcohol use or personality disorder. Results: The prevalence of comorbid personality disorders was 38% (22/58) and comorbid alcohol use disorders 41% (24/58). PD patients with a personality disorder diagnosis had an earlier onset age (p<0.01) and a higher mortality rate (p = 0.03). Male gender (p = 0.03), comorbid alcohol use disorder (p%lt;0.01) and personality disorder (p %lt; 0.01) were all associated with more psychiatric hospitalization. Comorbid alcohol use disorder was more common among men (males: 61%; females: 29%; p = 0.03). Limitations: National registers were the main source of diagnostic information. Conclusions: Gender and psychiatric comorbidity have significant implications for the course of illness in PD in naturalistic settings, which is an important message for all clinicians. More research into the heterogeneity of PD is needed in order to guide research and clinical practice. |
format |
Article in Journal/Newspaper |
author |
Nietola, M. (Miika) Nordström, T. (Tanja) Miettunen, J. (Jouko) Korkeila, J. (Jyrki) Jääskeläinen, E. (Erika) |
author_facet |
Nietola, M. (Miika) Nordström, T. (Tanja) Miettunen, J. (Jouko) Korkeila, J. (Jyrki) Jääskeläinen, E. (Erika) |
author_sort |
Nietola, M. (Miika) |
title |
Effects of gender and psychiatric comorbidity on the age of illness onset and the outcome of psychotic depression:a birth cohort study |
title_short |
Effects of gender and psychiatric comorbidity on the age of illness onset and the outcome of psychotic depression:a birth cohort study |
title_full |
Effects of gender and psychiatric comorbidity on the age of illness onset and the outcome of psychotic depression:a birth cohort study |
title_fullStr |
Effects of gender and psychiatric comorbidity on the age of illness onset and the outcome of psychotic depression:a birth cohort study |
title_full_unstemmed |
Effects of gender and psychiatric comorbidity on the age of illness onset and the outcome of psychotic depression:a birth cohort study |
title_sort |
effects of gender and psychiatric comorbidity on the age of illness onset and the outcome of psychotic depression:a birth cohort study |
publisher |
Elsevier |
publishDate |
2022 |
url |
http://urn.fi/urn:nbn:fi-fe2021121761261 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_rights |
info:eu-repo/semantics/openAccess © 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). https://creativecommons.org/licenses/by/4.0/ |
_version_ |
1772818064453140480 |