Association of self-reported polycystic ovary syndrome, obesity, and weight gain from adolescence to adulthood with hypertensive disorders of pregnancy:a community-based approach
Abstract The purpose of this prospective, population-based cohort study was to evaluate the roles of polycystic ovary syndrome (PCOS), obesity, weight gain, and hyperandrogenemia in the development of hypertensive disorders of pregnancy (HDP) through fertile age both in PCOS and in non-PCOS women. T...
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Wolters Kluwer
2021
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Online Access: | http://urn.fi/urn:nbn:fi-fe2021112557030 |
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ftunivoulu:oai:oulu.fi:nbnfi-fe2021112557030 2023-07-30T04:05:50+02:00 Association of self-reported polycystic ovary syndrome, obesity, and weight gain from adolescence to adulthood with hypertensive disorders of pregnancy:a community-based approach Rantakallio, J. S. (Juhani S.S.) Nevalainen, J. E. (Jaana E.) West, S. I. (Sammeli I.) Ollila, M.-M. (Meri-Maija) Puukka, K. (Katri) Bloigu, A. H. (Aini H.) Järvelin, M.-R. (Marjo-Riitta) Tapanainen, J. S. (Juha S.) Franks, S. (Stephen) Dunkel, L. (Leo) Piltonen, T. T. (Terhi T.) Vääräsmäki, M. S. (Marja S.) Morin-Papunen, L. C. (Laure C.) 2021 application/pdf http://urn.fi/urn:nbn:fi-fe2021112557030 eng eng Wolters Kluwer info:eu-repo/grantAgreement/EC/H2020/733206/EU/Early-life stressors and LifeCycle health/LIFECYCLE info:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/suppl/10.1161/HYPERTENSIONAHA.120.15702 info:eu-repo/semantics/openAccess © 2021 American Heart Association, Inc. The final authenticated version is available online at https://doi.org/10.1161/HYPERTENSIONAHA.120.15702. cohort studies follow-up studies hyperandrogenism obesity polycystic ovary syndrome preeclampsia weight gain info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion 2021 ftunivoulu 2023-07-08T20:00:48Z Abstract The purpose of this prospective, population-based cohort study was to evaluate the roles of polycystic ovary syndrome (PCOS), obesity, weight gain, and hyperandrogenemia in the development of hypertensive disorders of pregnancy (HDP) through fertile age both in PCOS and in non-PCOS women. The study population—NFBC1966 (Northern Finland Birth Cohort 1966)—allowed a long-term follow-up of women from age 14 until 46 years who developed HDP (n=408) or did not (n=3373). HDP diagnosis was confirmed by combining hospital discharge records, data from Finnish Medical Birth Registers, and the questionnaire data at age 46. Women with self-reported PCOS (srPCOS; n=279), defined by both oligo-amenorrhea and hirsutism at age 31 or with PCOS diagnosis by age 46, were compared with women without reported PCOS (n=1577). Women with srPCOS had an increased HDP risk (odds ratio, 1.56 [95% CI, 1.03–2.37]), but the association disappeared after adjustment for body mass index. In women with srPCOS and HDP, body mass index increased from age 14 to 46 significantly more than in srPCOS women without HDP (median [interquartile range], 9.82 [6.23–14.6] and 7.21 [4.16–10.5] kg/m², respectively; P<0.001). Also, in non-PCOS women, the increase was higher in women with (7.54 [5.32–11.62] kg/m²; P<0.001) than without HDP (6.33 [3.90–9.33] kg/m²; P<0.001). Increase in waist circumference between ages 31 and 46 years was associated with HDP but not with PCOS. Hyperandrogenemia at 31 or 46 years did not associate with HDP (1.44 [0.98–2.11]). In conclusion, obesity, especially abdominal obesity, and weight gain from adolescence to age 46, but not srPCOS or hyperandrogenemia, were associated with an increased risk of HDP. Article in Journal/Newspaper Northern Finland Jultika - University of Oulu repository |
institution |
Open Polar |
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Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
cohort studies follow-up studies hyperandrogenism obesity polycystic ovary syndrome preeclampsia weight gain |
spellingShingle |
cohort studies follow-up studies hyperandrogenism obesity polycystic ovary syndrome preeclampsia weight gain Rantakallio, J. S. (Juhani S.S.) Nevalainen, J. E. (Jaana E.) West, S. I. (Sammeli I.) Ollila, M.-M. (Meri-Maija) Puukka, K. (Katri) Bloigu, A. H. (Aini H.) Järvelin, M.-R. (Marjo-Riitta) Tapanainen, J. S. (Juha S.) Franks, S. (Stephen) Dunkel, L. (Leo) Piltonen, T. T. (Terhi T.) Vääräsmäki, M. S. (Marja S.) Morin-Papunen, L. C. (Laure C.) Association of self-reported polycystic ovary syndrome, obesity, and weight gain from adolescence to adulthood with hypertensive disorders of pregnancy:a community-based approach |
topic_facet |
cohort studies follow-up studies hyperandrogenism obesity polycystic ovary syndrome preeclampsia weight gain |
description |
Abstract The purpose of this prospective, population-based cohort study was to evaluate the roles of polycystic ovary syndrome (PCOS), obesity, weight gain, and hyperandrogenemia in the development of hypertensive disorders of pregnancy (HDP) through fertile age both in PCOS and in non-PCOS women. The study population—NFBC1966 (Northern Finland Birth Cohort 1966)—allowed a long-term follow-up of women from age 14 until 46 years who developed HDP (n=408) or did not (n=3373). HDP diagnosis was confirmed by combining hospital discharge records, data from Finnish Medical Birth Registers, and the questionnaire data at age 46. Women with self-reported PCOS (srPCOS; n=279), defined by both oligo-amenorrhea and hirsutism at age 31 or with PCOS diagnosis by age 46, were compared with women without reported PCOS (n=1577). Women with srPCOS had an increased HDP risk (odds ratio, 1.56 [95% CI, 1.03–2.37]), but the association disappeared after adjustment for body mass index. In women with srPCOS and HDP, body mass index increased from age 14 to 46 significantly more than in srPCOS women without HDP (median [interquartile range], 9.82 [6.23–14.6] and 7.21 [4.16–10.5] kg/m², respectively; P<0.001). Also, in non-PCOS women, the increase was higher in women with (7.54 [5.32–11.62] kg/m²; P<0.001) than without HDP (6.33 [3.90–9.33] kg/m²; P<0.001). Increase in waist circumference between ages 31 and 46 years was associated with HDP but not with PCOS. Hyperandrogenemia at 31 or 46 years did not associate with HDP (1.44 [0.98–2.11]). In conclusion, obesity, especially abdominal obesity, and weight gain from adolescence to age 46, but not srPCOS or hyperandrogenemia, were associated with an increased risk of HDP. |
format |
Article in Journal/Newspaper |
author |
Rantakallio, J. S. (Juhani S.S.) Nevalainen, J. E. (Jaana E.) West, S. I. (Sammeli I.) Ollila, M.-M. (Meri-Maija) Puukka, K. (Katri) Bloigu, A. H. (Aini H.) Järvelin, M.-R. (Marjo-Riitta) Tapanainen, J. S. (Juha S.) Franks, S. (Stephen) Dunkel, L. (Leo) Piltonen, T. T. (Terhi T.) Vääräsmäki, M. S. (Marja S.) Morin-Papunen, L. C. (Laure C.) |
author_facet |
Rantakallio, J. S. (Juhani S.S.) Nevalainen, J. E. (Jaana E.) West, S. I. (Sammeli I.) Ollila, M.-M. (Meri-Maija) Puukka, K. (Katri) Bloigu, A. H. (Aini H.) Järvelin, M.-R. (Marjo-Riitta) Tapanainen, J. S. (Juha S.) Franks, S. (Stephen) Dunkel, L. (Leo) Piltonen, T. T. (Terhi T.) Vääräsmäki, M. S. (Marja S.) Morin-Papunen, L. C. (Laure C.) |
author_sort |
Rantakallio, J. S. (Juhani S.S.) |
title |
Association of self-reported polycystic ovary syndrome, obesity, and weight gain from adolescence to adulthood with hypertensive disorders of pregnancy:a community-based approach |
title_short |
Association of self-reported polycystic ovary syndrome, obesity, and weight gain from adolescence to adulthood with hypertensive disorders of pregnancy:a community-based approach |
title_full |
Association of self-reported polycystic ovary syndrome, obesity, and weight gain from adolescence to adulthood with hypertensive disorders of pregnancy:a community-based approach |
title_fullStr |
Association of self-reported polycystic ovary syndrome, obesity, and weight gain from adolescence to adulthood with hypertensive disorders of pregnancy:a community-based approach |
title_full_unstemmed |
Association of self-reported polycystic ovary syndrome, obesity, and weight gain from adolescence to adulthood with hypertensive disorders of pregnancy:a community-based approach |
title_sort |
association of self-reported polycystic ovary syndrome, obesity, and weight gain from adolescence to adulthood with hypertensive disorders of pregnancy:a community-based approach |
publisher |
Wolters Kluwer |
publishDate |
2021 |
url |
http://urn.fi/urn:nbn:fi-fe2021112557030 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
info:eu-repo/grantAgreement/EC/H2020/733206/EU/Early-life stressors and LifeCycle health/LIFECYCLE info:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/suppl/10.1161/HYPERTENSIONAHA.120.15702 |
op_rights |
info:eu-repo/semantics/openAccess © 2021 American Heart Association, Inc. The final authenticated version is available online at https://doi.org/10.1161/HYPERTENSIONAHA.120.15702. |
_version_ |
1772818094238990336 |