The role of polygenic risk and susceptibility genes in breast cancer over the course of life

• Main Authors: Mars, N. (Nina), Widén, E. (Elisabeth), Kerminen, S. (Sini), Meretoja, T. (Tuomo), Pirinen, M. (Matti), della Briotta Parolo, P. (Pietro), Palta, P. (Priit), . (), Palotie, A. (Aarno), Kaprio, J. (Jaakko), Joensuu, H. (Heikki), Daly, M. (Mark), Ripatti, S. (Samuli)
• Format: Article in Journal/Newspaper
• Language: English
• Published: Springer Nature 2020
• Subjects: Audrey; Hannula; Harri; Jaakko; Jukka; Kalle; Kari; Kati; Klaus; Lauri; Lotta; Olli; Pekka; Riley; Risto; Sanna; Tuuli; Ulla; Uusimaa; Uusitalo; Vesa; West Road; sami
• Online Access: http://urn.fi/urn:nbn:fi-fe2021111655679

Abstract Polygenic risk scores (PRS) for breast cancer have potential to improve risk prediction, but there is limited information on their utility in various clinical situations. Here we show that among 122,978 women in the FinnGen study with 8401 breast cancer cases, the PRS modifies the breast ca...