Resistance to gapeworm parasite has both additive and dominant genetic components in house sparrows, with evolutionary consequences for ability to respond to parasite challenge
Abstract Host–parasite relationships are likely to change over the coming decades in response to climate change and increased anthropogenic stressors. Understanding the genetic architecture of parasite resistance will aid prediction of species’ responses to intensified parasite challenge. The gapewo...
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ftunivoulu:oai:oulu.fi:nbnfi-fe2020110589349 2023-07-30T04:05:51+02:00 Resistance to gapeworm parasite has both additive and dominant genetic components in house sparrows, with evolutionary consequences for ability to respond to parasite challenge Lundregan, S. L. (Sarah L.) Niskanen, A. K. (Alina K.) Muff, S. (Stefanie) Holand, H. (Håkon) Kvalnes, T. (Thomas) Ringsby, T. (Thor‐Harald) Husby, A. (Arild) Jensen, H. (Henrik) 2020 application/pdf http://urn.fi/urn:nbn:fi-fe2020110589349 eng eng John Wiley & Sons info:eu-repo/semantics/openAccess © 2020 The Authors. Molecular Ecology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ GWAS additive genetic variance dominance variance heritability parasite resistance info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2020 ftunivoulu 2023-07-08T19:57:12Z Abstract Host–parasite relationships are likely to change over the coming decades in response to climate change and increased anthropogenic stressors. Understanding the genetic architecture of parasite resistance will aid prediction of species’ responses to intensified parasite challenge. The gapeworm “Syngamus trachea” is prevalent in natural bird populations and causes symptomatic infections ranging from mild to severe. The parasite may affect ecological processes by curtailing bird populations and is important due to its propensity to spread to commercially farmed birds. Our large‐scale data set on an insular house sparrow metapopulation in northern Norway includes information on gapeworm prevalence and infection intensity, allowing assessment of the genetics of parasite resistance in a natural system. To determine whether parasite resistance has a heritable genetic component, we performed variance component analyses using animal models. Resistance to gapeworm had substantial additive genetic and dominance variance, and genome‐wide association studies to identify single nucleotide polymorphisms associated with gapeworm resistance yielded multiple loci linked to immune function. Together with genome partitioning results, this indicates that resistance to gapeworm is under polygenic control in the house sparrow, and probably in other bird species. Hence, our results provide the foundation needed to study any eco‐evolutionary processes related to gapeworm infection, and show that it is necessary to use methods suitable for polygenic and nonadditive genetic effects on the phenotype. Article in Journal/Newspaper Northern Norway Jultika - University of Oulu repository Norway |
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Open Polar |
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Jultika - University of Oulu repository |
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ftunivoulu |
language |
English |
topic |
GWAS additive genetic variance dominance variance heritability parasite resistance |
spellingShingle |
GWAS additive genetic variance dominance variance heritability parasite resistance Lundregan, S. L. (Sarah L.) Niskanen, A. K. (Alina K.) Muff, S. (Stefanie) Holand, H. (Håkon) Kvalnes, T. (Thomas) Ringsby, T. (Thor‐Harald) Husby, A. (Arild) Jensen, H. (Henrik) Resistance to gapeworm parasite has both additive and dominant genetic components in house sparrows, with evolutionary consequences for ability to respond to parasite challenge |
topic_facet |
GWAS additive genetic variance dominance variance heritability parasite resistance |
description |
Abstract Host–parasite relationships are likely to change over the coming decades in response to climate change and increased anthropogenic stressors. Understanding the genetic architecture of parasite resistance will aid prediction of species’ responses to intensified parasite challenge. The gapeworm “Syngamus trachea” is prevalent in natural bird populations and causes symptomatic infections ranging from mild to severe. The parasite may affect ecological processes by curtailing bird populations and is important due to its propensity to spread to commercially farmed birds. Our large‐scale data set on an insular house sparrow metapopulation in northern Norway includes information on gapeworm prevalence and infection intensity, allowing assessment of the genetics of parasite resistance in a natural system. To determine whether parasite resistance has a heritable genetic component, we performed variance component analyses using animal models. Resistance to gapeworm had substantial additive genetic and dominance variance, and genome‐wide association studies to identify single nucleotide polymorphisms associated with gapeworm resistance yielded multiple loci linked to immune function. Together with genome partitioning results, this indicates that resistance to gapeworm is under polygenic control in the house sparrow, and probably in other bird species. Hence, our results provide the foundation needed to study any eco‐evolutionary processes related to gapeworm infection, and show that it is necessary to use methods suitable for polygenic and nonadditive genetic effects on the phenotype. |
format |
Article in Journal/Newspaper |
author |
Lundregan, S. L. (Sarah L.) Niskanen, A. K. (Alina K.) Muff, S. (Stefanie) Holand, H. (Håkon) Kvalnes, T. (Thomas) Ringsby, T. (Thor‐Harald) Husby, A. (Arild) Jensen, H. (Henrik) |
author_facet |
Lundregan, S. L. (Sarah L.) Niskanen, A. K. (Alina K.) Muff, S. (Stefanie) Holand, H. (Håkon) Kvalnes, T. (Thomas) Ringsby, T. (Thor‐Harald) Husby, A. (Arild) Jensen, H. (Henrik) |
author_sort |
Lundregan, S. L. (Sarah L.) |
title |
Resistance to gapeworm parasite has both additive and dominant genetic components in house sparrows, with evolutionary consequences for ability to respond to parasite challenge |
title_short |
Resistance to gapeworm parasite has both additive and dominant genetic components in house sparrows, with evolutionary consequences for ability to respond to parasite challenge |
title_full |
Resistance to gapeworm parasite has both additive and dominant genetic components in house sparrows, with evolutionary consequences for ability to respond to parasite challenge |
title_fullStr |
Resistance to gapeworm parasite has both additive and dominant genetic components in house sparrows, with evolutionary consequences for ability to respond to parasite challenge |
title_full_unstemmed |
Resistance to gapeworm parasite has both additive and dominant genetic components in house sparrows, with evolutionary consequences for ability to respond to parasite challenge |
title_sort |
resistance to gapeworm parasite has both additive and dominant genetic components in house sparrows, with evolutionary consequences for ability to respond to parasite challenge |
publisher |
John Wiley & Sons |
publishDate |
2020 |
url |
http://urn.fi/urn:nbn:fi-fe2020110589349 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Northern Norway |
genre_facet |
Northern Norway |
op_rights |
info:eu-repo/semantics/openAccess © 2020 The Authors. Molecular Ecology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ |
_version_ |
1772818131361726464 |