Vitamin D levels in women with polycystic ovary syndrome:a population-based study

• Main Authors: Lumme, J. (Johanna), Sebert, S. (Sylvain), Pesonen, P. (Paula), Piltonen, T. (Terhi), Järvelin, M.-R. (Marjo-Riitta), Herzig, K.-H. (Karl-Heinz), Auvinen, J. (Juha), Ojaniemi, M. (Marja), Niinimäki, M. (Maarit)
• Format: Article in Journal/Newspaper
• Language: English
• Published: Multidisciplinary Digital Publishing Institute 2019
• Subjects: 25(OH)D; body mass index; community setting; polycystic ovary syndrome; population-based study; vitamin D; Northern Finland
• Online Access: http://urn.fi/urn:nbn:fi-fe2019120245193

Abstract Background: Conflicting evidence supports a role for vitamin D in women with reproductive disorders such as polycystic ovary syndrome (PCOS) but studies on large, unselected populations have been lacking. Methods: We conducted a general population-based study from the prospective Northern Finland Birth Cohort 1966 (NFBC1966). Serum 25-hydroksyvitamin D (25(OH)D) levels were evaluated in women with self-reported PCOS (n = 280) versus non-symptomatic controls (n = 1573) at the age of 31 with wide range of endocrine and metabolic confounders. Results: The levels of 25(OH)D were similar among women with and without self-reported PCOS (50.35 vs. 48.30 nmol/L, p = 0.051). Women with self-reported PCOS presented with a higher body mass index (BMI), increased insulin resistance, and low-grade inflammation and testosterone levels compared to controls. The adjusted linear regression model showed a positive association between total 25(OH)D levels in self-reported PCOS (β = 2.46, 95% confidence interval (CI) 0.84 to 4.08, p = 0.003). The result remained after adjustment for BMI, testosterone, homeostatic model assessment of insulin resistance (HOMA-IR), and high-sensitivity C-reactive protein (hs-CRP) levels. Conclusion: In this population-based setting, PCOS was associated with higher vitamin D levels when adjusting for confounding factors, without distinct beneficial effects on metabolic derangements.