Association between developmental milestones and age of schizophrenia onset:results from the Northern Finland Birth Cohort 1966
Abstract We investigated relationships between early developmental milestones, schizophrenia incidence and variability in its age at onset. We hypothesized that the period of risk for schizophrenia would be longer for those with later development. The Northern Finland Birth Cohort 1966 was followed...
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ftunivoulu:oai:oulu.fi:nbnfi-fe2019100130667 2023-07-30T04:05:48+02:00 Association between developmental milestones and age of schizophrenia onset:results from the Northern Finland Birth Cohort 1966 Stochl, J. (Jan) Whittier, A. (Anjalene) Wagner, A. P. (Adam P.) Veijola, J. (Juha) Jääskeläinen, E. (Erika) Miettunen, J. (Jouko) Khandaker, G. M. (Golam M.) Jones, P. B. (Peter B.) 2019 application/pdf http://urn.fi/urn:nbn:fi-fe2019100130667 eng eng Elsevier info:eu-repo/semantics/openAccess © 2019 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). https://creativecommons.org/licenses/by/4.0/ age at onset developmental milestones non-affective psychoses schizophrenia info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2019 ftunivoulu 2023-07-08T19:56:06Z Abstract We investigated relationships between early developmental milestones, schizophrenia incidence and variability in its age at onset. We hypothesized that the period of risk for schizophrenia would be longer for those with later development. The Northern Finland Birth Cohort 1966 was followed until 47 years of age, and those members diagnosed with schizophrenia or any other non-affective psychoses identified. Latent profile analysis was used to classify people into homogenous classes with respect to developmental milestones, and subsequently survival analysis explored relationship between classes and age of schizophrenia onset. Results suggest that 4-classes (early, regular, late, and extra late developers) can be identified, but due to few cases in one class (n = 93, <0.01% of 10,501), only 3 classes (early, regular, late) could be meaningfully compared. Schizophrenia incidence until 47 years of age differed systematically between classes: late developers had the highest cumulative incidence (2.39%); regular were intermediate (1.25%); and early developers had the lowest incidence (0.99%). However, age at onset and its variability was similar across classes, suggesting that our hypothesis of a wider ‘window’ for schizophrenia onset in late developers was not supported. Article in Journal/Newspaper Northern Finland Jultika - University of Oulu repository |
institution |
Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
age at onset developmental milestones non-affective psychoses schizophrenia |
spellingShingle |
age at onset developmental milestones non-affective psychoses schizophrenia Stochl, J. (Jan) Whittier, A. (Anjalene) Wagner, A. P. (Adam P.) Veijola, J. (Juha) Jääskeläinen, E. (Erika) Miettunen, J. (Jouko) Khandaker, G. M. (Golam M.) Jones, P. B. (Peter B.) Association between developmental milestones and age of schizophrenia onset:results from the Northern Finland Birth Cohort 1966 |
topic_facet |
age at onset developmental milestones non-affective psychoses schizophrenia |
description |
Abstract We investigated relationships between early developmental milestones, schizophrenia incidence and variability in its age at onset. We hypothesized that the period of risk for schizophrenia would be longer for those with later development. The Northern Finland Birth Cohort 1966 was followed until 47 years of age, and those members diagnosed with schizophrenia or any other non-affective psychoses identified. Latent profile analysis was used to classify people into homogenous classes with respect to developmental milestones, and subsequently survival analysis explored relationship between classes and age of schizophrenia onset. Results suggest that 4-classes (early, regular, late, and extra late developers) can be identified, but due to few cases in one class (n = 93, <0.01% of 10,501), only 3 classes (early, regular, late) could be meaningfully compared. Schizophrenia incidence until 47 years of age differed systematically between classes: late developers had the highest cumulative incidence (2.39%); regular were intermediate (1.25%); and early developers had the lowest incidence (0.99%). However, age at onset and its variability was similar across classes, suggesting that our hypothesis of a wider ‘window’ for schizophrenia onset in late developers was not supported. |
format |
Article in Journal/Newspaper |
author |
Stochl, J. (Jan) Whittier, A. (Anjalene) Wagner, A. P. (Adam P.) Veijola, J. (Juha) Jääskeläinen, E. (Erika) Miettunen, J. (Jouko) Khandaker, G. M. (Golam M.) Jones, P. B. (Peter B.) |
author_facet |
Stochl, J. (Jan) Whittier, A. (Anjalene) Wagner, A. P. (Adam P.) Veijola, J. (Juha) Jääskeläinen, E. (Erika) Miettunen, J. (Jouko) Khandaker, G. M. (Golam M.) Jones, P. B. (Peter B.) |
author_sort |
Stochl, J. (Jan) |
title |
Association between developmental milestones and age of schizophrenia onset:results from the Northern Finland Birth Cohort 1966 |
title_short |
Association between developmental milestones and age of schizophrenia onset:results from the Northern Finland Birth Cohort 1966 |
title_full |
Association between developmental milestones and age of schizophrenia onset:results from the Northern Finland Birth Cohort 1966 |
title_fullStr |
Association between developmental milestones and age of schizophrenia onset:results from the Northern Finland Birth Cohort 1966 |
title_full_unstemmed |
Association between developmental milestones and age of schizophrenia onset:results from the Northern Finland Birth Cohort 1966 |
title_sort |
association between developmental milestones and age of schizophrenia onset:results from the northern finland birth cohort 1966 |
publisher |
Elsevier |
publishDate |
2019 |
url |
http://urn.fi/urn:nbn:fi-fe2019100130667 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_rights |
info:eu-repo/semantics/openAccess © 2019 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). https://creativecommons.org/licenses/by/4.0/ |
_version_ |
1772817978585251840 |