Genetic basis of amphibian larval development along a latitudinal gradient:gene diversity, selection and links with phenotypic variation in transcription factor C/EBP‐1
Abstract Ectotherm development rates often show adaptive divergence along climatic gradients, but the genetic basis for this variation is rarely studied. Here, we investigated the genetic basis for phenotypic variation in larval development in the moor frog Rana arvalis from five regions along a lat...
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ftunivoulu:oai:oulu.fi:nbnfi-fe2019093030533 2023-07-30T04:05:52+02:00 Genetic basis of amphibian larval development along a latitudinal gradient:gene diversity, selection and links with phenotypic variation in transcription factor C/EBP‐1 Meyer‐Lucht, Y. (Yvonne) Luquet, E. (Emilien) Jóhannesdóttir, F. (Fríða) Rödin‐Mörch, P. (Patrik) Quintela, M. (María) Richter‐Boix, A. (Alex) Höglund, J. (Jacob) Laurila, A. (Anssi) 2019 application/pdf http://urn.fi/urn:nbn:fi-fe2019093030533 eng eng John Wiley & Sons info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.5061/dryad.2508t4h info:eu-repo/semantics/openAccess © 2019 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Meyer‐Lucht, Y, Luquet, E, Jóhannesdóttir, F, et al. Genetic basis of amphibian larval development along a latitudinal gradient: Gene diversity, selection and links with phenotypic variation in transcription factor C/EBP‐1. Mol Ecol. 2019; 28: 2786–2801, which has been published in final form at https://doi.org/10.1111/mec.15123. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving adaptation amphibians climate change ecological genetics life history evolution info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2019 ftunivoulu https://doi.org/10.5061/dryad.2508t4h 2023-07-08T19:56:42Z Abstract Ectotherm development rates often show adaptive divergence along climatic gradients, but the genetic basis for this variation is rarely studied. Here, we investigated the genetic basis for phenotypic variation in larval development in the moor frog Rana arvalis from five regions along a latitudinal gradient from Germany to northern Sweden. We focused on the C/EBP‐1 gene, a transcription factor associated with larval development time. Allele frequencies at C/EBP‐1 varied strongly among geographical regions. Overall, the distribution of alleles along the gradient was in concordance with the dual post‐glacial colonization routes into Scandinavia, with a large number of alleles exclusively present along the southern colonization route. Only three of 38 alleles were shared between the routes. Analysis of contemporary selection on C/EBP‐1 showed divergent selection among the regions, probably reflecting adaptation to the local environmental conditions, although this was especially strong between southern and northern regions coinciding also with lineages from different colonization routes. Overall, the C/EBP‐1 gene has historically been under purifying selection, but two specific amino acid positions showed significant signals of positive selection. These positions showed divergence between southern and northern regions, and we suggest that they are functionally involved in the climatic adaptation of larval development. Using phenotypic data from a common garden experiment, we found evidence for specific C/EBP‐1 alleles being correlated with larval development time, suggesting a functional role in adaptation of larval development to large‐scale climatic variation. Article in Journal/Newspaper Northern Sweden Jultika - University of Oulu repository |
institution |
Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
adaptation amphibians climate change ecological genetics life history evolution |
spellingShingle |
adaptation amphibians climate change ecological genetics life history evolution Meyer‐Lucht, Y. (Yvonne) Luquet, E. (Emilien) Jóhannesdóttir, F. (Fríða) Rödin‐Mörch, P. (Patrik) Quintela, M. (María) Richter‐Boix, A. (Alex) Höglund, J. (Jacob) Laurila, A. (Anssi) Genetic basis of amphibian larval development along a latitudinal gradient:gene diversity, selection and links with phenotypic variation in transcription factor C/EBP‐1 |
topic_facet |
adaptation amphibians climate change ecological genetics life history evolution |
description |
Abstract Ectotherm development rates often show adaptive divergence along climatic gradients, but the genetic basis for this variation is rarely studied. Here, we investigated the genetic basis for phenotypic variation in larval development in the moor frog Rana arvalis from five regions along a latitudinal gradient from Germany to northern Sweden. We focused on the C/EBP‐1 gene, a transcription factor associated with larval development time. Allele frequencies at C/EBP‐1 varied strongly among geographical regions. Overall, the distribution of alleles along the gradient was in concordance with the dual post‐glacial colonization routes into Scandinavia, with a large number of alleles exclusively present along the southern colonization route. Only three of 38 alleles were shared between the routes. Analysis of contemporary selection on C/EBP‐1 showed divergent selection among the regions, probably reflecting adaptation to the local environmental conditions, although this was especially strong between southern and northern regions coinciding also with lineages from different colonization routes. Overall, the C/EBP‐1 gene has historically been under purifying selection, but two specific amino acid positions showed significant signals of positive selection. These positions showed divergence between southern and northern regions, and we suggest that they are functionally involved in the climatic adaptation of larval development. Using phenotypic data from a common garden experiment, we found evidence for specific C/EBP‐1 alleles being correlated with larval development time, suggesting a functional role in adaptation of larval development to large‐scale climatic variation. |
format |
Article in Journal/Newspaper |
author |
Meyer‐Lucht, Y. (Yvonne) Luquet, E. (Emilien) Jóhannesdóttir, F. (Fríða) Rödin‐Mörch, P. (Patrik) Quintela, M. (María) Richter‐Boix, A. (Alex) Höglund, J. (Jacob) Laurila, A. (Anssi) |
author_facet |
Meyer‐Lucht, Y. (Yvonne) Luquet, E. (Emilien) Jóhannesdóttir, F. (Fríða) Rödin‐Mörch, P. (Patrik) Quintela, M. (María) Richter‐Boix, A. (Alex) Höglund, J. (Jacob) Laurila, A. (Anssi) |
author_sort |
Meyer‐Lucht, Y. (Yvonne) |
title |
Genetic basis of amphibian larval development along a latitudinal gradient:gene diversity, selection and links with phenotypic variation in transcription factor C/EBP‐1 |
title_short |
Genetic basis of amphibian larval development along a latitudinal gradient:gene diversity, selection and links with phenotypic variation in transcription factor C/EBP‐1 |
title_full |
Genetic basis of amphibian larval development along a latitudinal gradient:gene diversity, selection and links with phenotypic variation in transcription factor C/EBP‐1 |
title_fullStr |
Genetic basis of amphibian larval development along a latitudinal gradient:gene diversity, selection and links with phenotypic variation in transcription factor C/EBP‐1 |
title_full_unstemmed |
Genetic basis of amphibian larval development along a latitudinal gradient:gene diversity, selection and links with phenotypic variation in transcription factor C/EBP‐1 |
title_sort |
genetic basis of amphibian larval development along a latitudinal gradient:gene diversity, selection and links with phenotypic variation in transcription factor c/ebp‐1 |
publisher |
John Wiley & Sons |
publishDate |
2019 |
url |
http://urn.fi/urn:nbn:fi-fe2019093030533 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.5061/dryad.2508t4h |
op_rights |
info:eu-repo/semantics/openAccess © 2019 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Meyer‐Lucht, Y, Luquet, E, Jóhannesdóttir, F, et al. Genetic basis of amphibian larval development along a latitudinal gradient: Gene diversity, selection and links with phenotypic variation in transcription factor C/EBP‐1. Mol Ecol. 2019; 28: 2786–2801, which has been published in final form at https://doi.org/10.1111/mec.15123. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving |
op_doi |
https://doi.org/10.5061/dryad.2508t4h |
_version_ |
1772818172736438272 |