Cardiac autonomic function in adults born preterm
Abstract Objective: To evaluate cardiac autonomic function in adults born preterm. Study design: We studied the association between prematurity and cardiac autonomic function using heart rate variability measurements in 600 adults (mean age of 23.3 years) from a geographically based cohort in Northe...
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ftunivoulu:oai:oulu.fi:nbnfi-fe2019051515693 2023-07-30T04:05:49+02:00 Cardiac autonomic function in adults born preterm Karvonen, R. (Risto) Sipola, M. (Marika) Kiviniemi, A. (Antti) Tikanmäki, M. (Marjaana) Järvelin, M.-R. (Marjo-Riitta) Eriksson, J. G. (Johan G.) Tulppo, M. (Mikko) Vääräsmäki, M. (Marja) Kajantie, E. (Eero) 2019 application/pdf http://urn.fi/urn:nbn:fi-fe2019051515693 eng eng Elsevier info:eu-repo/grantAgreement/EC/H2020/633595/EU/Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging/DYNAHEALTH info:eu-repo/semantics/openAccess © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http:/creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/ autonomic control birth weight gestational age heart rate variability parasympathetic premature birth sympathetic info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion 2019 ftunivoulu 2023-07-08T19:56:23Z Abstract Objective: To evaluate cardiac autonomic function in adults born preterm. Study design: We studied the association between prematurity and cardiac autonomic function using heart rate variability measurements in 600 adults (mean age of 23.3 years) from a geographically based cohort in Northern Finland. There were 117 young adults born early preterm (<34 weeks), 207 born late preterm (34–36 weeks), and 276 born at term (≥37 weeks, controls). Autonomic function was analyzed by calculating time and frequency domain heart rate variability measurements using linear regression. Results: Compared with controls, the mean difference in root mean square of successive differences (indicating cardiac vagal activity) was −12.0% (95% CI −22.2%, −0.5%, adjusted for sex, age, source cohort, and season P = .04) for the early preterm group and −7.8% (−16.8%, 2.0%, P = .12) for the late preterm group. Mean differences with controls in low frequency power (indicating cardiac vagal activity, including some sympathetic- and baroreflex-mediated effects) were −13.6% (−26.7%, 1.8%, P = .08) for the early preterm group and −16.4% (−27.0%, −4.3%, P = .01) for the late preterm group. Mean differences in high frequency power (quantifying cardiac vagal modulation in respiratory frequency) were −19.2% (−36.6%, 2.9%, P = .09) for the early preterm group and −13.8% (−29.4%, 5.3%, P = .15) for the late preterm group. Differences were attenuated when controlled for body mass index and physical activity. Conclusions: Our results suggest altered autonomic regulatory control in adults born preterm, including those born late preterm. Altered autonomic regulatory control may contribute to increased cardiovascular risk in adults born preterm. Article in Journal/Newspaper Northern Finland Jultika - University of Oulu repository |
institution |
Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
autonomic control birth weight gestational age heart rate variability parasympathetic premature birth sympathetic |
spellingShingle |
autonomic control birth weight gestational age heart rate variability parasympathetic premature birth sympathetic Karvonen, R. (Risto) Sipola, M. (Marika) Kiviniemi, A. (Antti) Tikanmäki, M. (Marjaana) Järvelin, M.-R. (Marjo-Riitta) Eriksson, J. G. (Johan G.) Tulppo, M. (Mikko) Vääräsmäki, M. (Marja) Kajantie, E. (Eero) Cardiac autonomic function in adults born preterm |
topic_facet |
autonomic control birth weight gestational age heart rate variability parasympathetic premature birth sympathetic |
description |
Abstract Objective: To evaluate cardiac autonomic function in adults born preterm. Study design: We studied the association between prematurity and cardiac autonomic function using heart rate variability measurements in 600 adults (mean age of 23.3 years) from a geographically based cohort in Northern Finland. There were 117 young adults born early preterm (<34 weeks), 207 born late preterm (34–36 weeks), and 276 born at term (≥37 weeks, controls). Autonomic function was analyzed by calculating time and frequency domain heart rate variability measurements using linear regression. Results: Compared with controls, the mean difference in root mean square of successive differences (indicating cardiac vagal activity) was −12.0% (95% CI −22.2%, −0.5%, adjusted for sex, age, source cohort, and season P = .04) for the early preterm group and −7.8% (−16.8%, 2.0%, P = .12) for the late preterm group. Mean differences with controls in low frequency power (indicating cardiac vagal activity, including some sympathetic- and baroreflex-mediated effects) were −13.6% (−26.7%, 1.8%, P = .08) for the early preterm group and −16.4% (−27.0%, −4.3%, P = .01) for the late preterm group. Mean differences in high frequency power (quantifying cardiac vagal modulation in respiratory frequency) were −19.2% (−36.6%, 2.9%, P = .09) for the early preterm group and −13.8% (−29.4%, 5.3%, P = .15) for the late preterm group. Differences were attenuated when controlled for body mass index and physical activity. Conclusions: Our results suggest altered autonomic regulatory control in adults born preterm, including those born late preterm. Altered autonomic regulatory control may contribute to increased cardiovascular risk in adults born preterm. |
format |
Article in Journal/Newspaper |
author |
Karvonen, R. (Risto) Sipola, M. (Marika) Kiviniemi, A. (Antti) Tikanmäki, M. (Marjaana) Järvelin, M.-R. (Marjo-Riitta) Eriksson, J. G. (Johan G.) Tulppo, M. (Mikko) Vääräsmäki, M. (Marja) Kajantie, E. (Eero) |
author_facet |
Karvonen, R. (Risto) Sipola, M. (Marika) Kiviniemi, A. (Antti) Tikanmäki, M. (Marjaana) Järvelin, M.-R. (Marjo-Riitta) Eriksson, J. G. (Johan G.) Tulppo, M. (Mikko) Vääräsmäki, M. (Marja) Kajantie, E. (Eero) |
author_sort |
Karvonen, R. (Risto) |
title |
Cardiac autonomic function in adults born preterm |
title_short |
Cardiac autonomic function in adults born preterm |
title_full |
Cardiac autonomic function in adults born preterm |
title_fullStr |
Cardiac autonomic function in adults born preterm |
title_full_unstemmed |
Cardiac autonomic function in adults born preterm |
title_sort |
cardiac autonomic function in adults born preterm |
publisher |
Elsevier |
publishDate |
2019 |
url |
http://urn.fi/urn:nbn:fi-fe2019051515693 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
info:eu-repo/grantAgreement/EC/H2020/633595/EU/Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging/DYNAHEALTH |
op_rights |
info:eu-repo/semantics/openAccess © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http:/creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/ |
_version_ |
1772818053327749120 |