Diverse age-incidence patterns of atopic sensitization in an unselected Finnish population up to 12 years
Abstract Background: The temporal sequence in which allergic sensitization to different allergens emerges is not well characterized at the level of general population. Objective: We describe the incidence patterns of atopic sensitization to different allergens from birth up to 12 years of age in an...
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ftunivoulu:oai:oulu.fi:nbnfi-fe2019051515578 2023-07-30T04:04:36+02:00 Diverse age-incidence patterns of atopic sensitization in an unselected Finnish population up to 12 years Pyrhönen, K. (Kaisa) Kulmala, P. (Petri) Näyhä, S. (Simo) Läärä, E. (Esa) 2019 application/pdf http://urn.fi/urn:nbn:fi-fe2019051515578 eng eng Elsevier info:eu-repo/semantics/openAccess © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http:/creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion 2019 ftunivoulu 2023-07-08T19:56:28Z Abstract Background: The temporal sequence in which allergic sensitization to different allergens emerges is not well characterized at the level of general population. Objective: We describe the incidence patterns of atopic sensitization to different allergens from birth up to 12 years of age in an unselected Finnish population. Methods: The study population comprised all children born between 2001 and 2006 identified from the nationwide population register as residents of the province of South Karelia, Finland (n = 5564). The results of allergy tests (22,380 results from skin prick tests, immunoglobulin E [IgE] antibodies, and open food challenges [OFCs], performed in 1827 children) were collected from patient records of all the health care units in the area. Results: The incidence rates of positive results for food and animal allergens as well as positive OFCs for cow’s milk showed prominent peaks at 5 months of age. Positive results for pollen allergens started to emerge after 1.5 years of age. The 12-year cumulative incidence of sensitization to food, animal, pollen, and any allergens was 12%, 8%, 10%, and 18%, respectively. The cumulative incidence of sensitization to house dust mites was 1% and to molds or latex less than 1%. Firstborn boys had the highest, and those who were not firstborn girls and children born in rural municipalities had the lowest early incidence of sensitization to inhalation allergens. Conclusion: In the unselected population, the atopic sensitization against food and animal allergens began before 6 months of age and was followed by sensitization to pollen allergens before 2 years of age. Primary prevention of sensitization to food and inhalation allergens should therefore occur in early infancy. Article in Journal/Newspaper karelia* Jultika - University of Oulu repository |
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Open Polar |
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Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
description |
Abstract Background: The temporal sequence in which allergic sensitization to different allergens emerges is not well characterized at the level of general population. Objective: We describe the incidence patterns of atopic sensitization to different allergens from birth up to 12 years of age in an unselected Finnish population. Methods: The study population comprised all children born between 2001 and 2006 identified from the nationwide population register as residents of the province of South Karelia, Finland (n = 5564). The results of allergy tests (22,380 results from skin prick tests, immunoglobulin E [IgE] antibodies, and open food challenges [OFCs], performed in 1827 children) were collected from patient records of all the health care units in the area. Results: The incidence rates of positive results for food and animal allergens as well as positive OFCs for cow’s milk showed prominent peaks at 5 months of age. Positive results for pollen allergens started to emerge after 1.5 years of age. The 12-year cumulative incidence of sensitization to food, animal, pollen, and any allergens was 12%, 8%, 10%, and 18%, respectively. The cumulative incidence of sensitization to house dust mites was 1% and to molds or latex less than 1%. Firstborn boys had the highest, and those who were not firstborn girls and children born in rural municipalities had the lowest early incidence of sensitization to inhalation allergens. Conclusion: In the unselected population, the atopic sensitization against food and animal allergens began before 6 months of age and was followed by sensitization to pollen allergens before 2 years of age. Primary prevention of sensitization to food and inhalation allergens should therefore occur in early infancy. |
format |
Article in Journal/Newspaper |
author |
Pyrhönen, K. (Kaisa) Kulmala, P. (Petri) Näyhä, S. (Simo) Läärä, E. (Esa) |
spellingShingle |
Pyrhönen, K. (Kaisa) Kulmala, P. (Petri) Näyhä, S. (Simo) Läärä, E. (Esa) Diverse age-incidence patterns of atopic sensitization in an unselected Finnish population up to 12 years |
author_facet |
Pyrhönen, K. (Kaisa) Kulmala, P. (Petri) Näyhä, S. (Simo) Läärä, E. (Esa) |
author_sort |
Pyrhönen, K. (Kaisa) |
title |
Diverse age-incidence patterns of atopic sensitization in an unselected Finnish population up to 12 years |
title_short |
Diverse age-incidence patterns of atopic sensitization in an unselected Finnish population up to 12 years |
title_full |
Diverse age-incidence patterns of atopic sensitization in an unselected Finnish population up to 12 years |
title_fullStr |
Diverse age-incidence patterns of atopic sensitization in an unselected Finnish population up to 12 years |
title_full_unstemmed |
Diverse age-incidence patterns of atopic sensitization in an unselected Finnish population up to 12 years |
title_sort |
diverse age-incidence patterns of atopic sensitization in an unselected finnish population up to 12 years |
publisher |
Elsevier |
publishDate |
2019 |
url |
http://urn.fi/urn:nbn:fi-fe2019051515578 |
genre |
karelia* |
genre_facet |
karelia* |
op_rights |
info:eu-repo/semantics/openAccess © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http:/creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/ |
_version_ |
1772816143539503104 |