Do adverse perinatal events predict mortality in schizophrenia during midlife?
Abstract Background: We examined mortality in schizophrenia spectrum disorder (SSD) and non-schizophrenic psychosis (NSSD) compared to individuals without psychosis, and whether perinatal factors predict mortality. Methods: Within Northern Finland Birth Cohort 1966 (n = 10 933; 203 with SSD, 178 wit...
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ftunivoulu:oai:oulu.fi:nbnfi-fe2018050219295 2023-07-30T04:05:49+02:00 Do adverse perinatal events predict mortality in schizophrenia during midlife? Rautio, N. (Nina) Miettunen, J. (Jouko) Jääskeläinen, E. (Erika) Nordström, T. (Tanja) Isohanni, M. (Matti) Seppälä, J. (Jussi) 2017 application/pdf http://urn.fi/urn:nbn:fi-fe2018050219295 eng eng Elsevier info:eu-repo/grantAgreement/EC/H2020/643552/EU/Mobile Therapeutic Attention for Patients with Treatment Resistant Schizophrenia/m-RESIST info:eu-repo/grantAgreement/EC/H2020/633595/EU/Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging/DYNAHEALTH info:eu-repo/semantics/altIdentifier/pissn/0920-9964 info:eu-repo/semantics/altIdentifier/eissn/1573-2509 info:eu-repo/semantics/openAccess © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/ Mortality Perinatal circumstances Psychoses info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion 2017 ftunivoulu 2023-07-08T19:59:56Z Abstract Background: We examined mortality in schizophrenia spectrum disorder (SSD) and non-schizophrenic psychosis (NSSD) compared to individuals without psychosis, and whether perinatal factors predict mortality. Methods: Within Northern Finland Birth Cohort 1966 (n = 10 933; 203 with SSD, 178 with NSSD), mortality was followed until end of 2011 by national register. Wantedness of pregnancy, mother’s antenatal depression, smoking and age, parity, paternal socio-economic status (SES) and family type at birth were examined as predictors of mortality. Results: Mortality was higher in SSD (hazard ratio (HR) 3.60; 95% confidence interval (CI) 2.38–5.45) and NSSD (4.05; 2.65–6.17) compared to persons without psychoses after adjustment for gender. HR for natural death was 2.01 (0.82–4.91) in SSD and 4.63 (2.43–8.80) in NSSD after adjustment for gender. Corresponding figures for unnatural deaths were 4.71 (2.94–7.54) and 2.94 (1.56–5.55), respectively. Among non-psychotic persons, mother’s depression, smoking and low SES predicted mortality after adjustment for gender and parental psychoses (and SES), whereas among psychosis those whose father was a farmer had lower risk of mortality compared to those with high SES. Conclusions: Individuals with SSD had a higher risk of unnatural death and individuals with NSSD of natural and unnatural deaths. Perinatal factors seem to be more important predictors of mortality in individuals without psychoses than with psychoses. According to population-based long follow-up data, it is important to pay attention to somatic morbidity behind natural causes of death in psychoses and to prevent suicides in order to prevent excess mortality. Article in Journal/Newspaper Northern Finland Jultika - University of Oulu repository |
institution |
Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
Mortality Perinatal circumstances Psychoses |
spellingShingle |
Mortality Perinatal circumstances Psychoses Rautio, N. (Nina) Miettunen, J. (Jouko) Jääskeläinen, E. (Erika) Nordström, T. (Tanja) Isohanni, M. (Matti) Seppälä, J. (Jussi) Do adverse perinatal events predict mortality in schizophrenia during midlife? |
topic_facet |
Mortality Perinatal circumstances Psychoses |
description |
Abstract Background: We examined mortality in schizophrenia spectrum disorder (SSD) and non-schizophrenic psychosis (NSSD) compared to individuals without psychosis, and whether perinatal factors predict mortality. Methods: Within Northern Finland Birth Cohort 1966 (n = 10 933; 203 with SSD, 178 with NSSD), mortality was followed until end of 2011 by national register. Wantedness of pregnancy, mother’s antenatal depression, smoking and age, parity, paternal socio-economic status (SES) and family type at birth were examined as predictors of mortality. Results: Mortality was higher in SSD (hazard ratio (HR) 3.60; 95% confidence interval (CI) 2.38–5.45) and NSSD (4.05; 2.65–6.17) compared to persons without psychoses after adjustment for gender. HR for natural death was 2.01 (0.82–4.91) in SSD and 4.63 (2.43–8.80) in NSSD after adjustment for gender. Corresponding figures for unnatural deaths were 4.71 (2.94–7.54) and 2.94 (1.56–5.55), respectively. Among non-psychotic persons, mother’s depression, smoking and low SES predicted mortality after adjustment for gender and parental psychoses (and SES), whereas among psychosis those whose father was a farmer had lower risk of mortality compared to those with high SES. Conclusions: Individuals with SSD had a higher risk of unnatural death and individuals with NSSD of natural and unnatural deaths. Perinatal factors seem to be more important predictors of mortality in individuals without psychoses than with psychoses. According to population-based long follow-up data, it is important to pay attention to somatic morbidity behind natural causes of death in psychoses and to prevent suicides in order to prevent excess mortality. |
format |
Article in Journal/Newspaper |
author |
Rautio, N. (Nina) Miettunen, J. (Jouko) Jääskeläinen, E. (Erika) Nordström, T. (Tanja) Isohanni, M. (Matti) Seppälä, J. (Jussi) |
author_facet |
Rautio, N. (Nina) Miettunen, J. (Jouko) Jääskeläinen, E. (Erika) Nordström, T. (Tanja) Isohanni, M. (Matti) Seppälä, J. (Jussi) |
author_sort |
Rautio, N. (Nina) |
title |
Do adverse perinatal events predict mortality in schizophrenia during midlife? |
title_short |
Do adverse perinatal events predict mortality in schizophrenia during midlife? |
title_full |
Do adverse perinatal events predict mortality in schizophrenia during midlife? |
title_fullStr |
Do adverse perinatal events predict mortality in schizophrenia during midlife? |
title_full_unstemmed |
Do adverse perinatal events predict mortality in schizophrenia during midlife? |
title_sort |
do adverse perinatal events predict mortality in schizophrenia during midlife? |
publisher |
Elsevier |
publishDate |
2017 |
url |
http://urn.fi/urn:nbn:fi-fe2018050219295 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
info:eu-repo/grantAgreement/EC/H2020/643552/EU/Mobile Therapeutic Attention for Patients with Treatment Resistant Schizophrenia/m-RESIST info:eu-repo/grantAgreement/EC/H2020/633595/EU/Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging/DYNAHEALTH info:eu-repo/semantics/altIdentifier/pissn/0920-9964 info:eu-repo/semantics/altIdentifier/eissn/1573-2509 |
op_rights |
info:eu-repo/semantics/openAccess © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/ |
_version_ |
1772818047824822272 |