Metabolic health and obesity: early determinants, trajectories and causal analysis:the Northern Finland Birth Cohort 1966 and 1986 studies
Abstract The obesity epidemic has grown over the last four decades in most European countries including Finland where 21.5% of women and 20% of men are now living with obesity. There is a large body of evidence establishing that the first years of life, including the foetal period, are critical for...
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Oulun yliopisto
2023
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ftunivoulu:oai:oulu.fi:isbn978-952-62-3700-8 2023-07-30T04:05:49+02:00 Metabolic health and obesity: early determinants, trajectories and causal analysis:the Northern Finland Birth Cohort 1966 and 1986 studies Nedelec, R. (Rozenn) Järvelin, M. (Marjo-Riitta) Miettunen, J. (Jouko) Ruddock, M. (Minna) 2023-06-05 application/pdf http://urn.fi/urn:isbn:9789526237008 eng eng Oulun yliopisto info:eu-repo/grantAgreement/EC/FP7/277849/EU/European ResearcH on DevElopmentAL, BirtH and Genetic Determinants of Ageing/EURHEALTHAGEING info:eu-repo/grantAgreement/EC/H2020/633595/EU/Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging/DYNAHEALTH info:eu-repo/grantAgreement/EC/H2020/733206/EU/Early-life stressors and LifeCycle health/LIFECYCLE info:eu-repo/grantAgreement/EC/H2020/848158/EU/Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity/EarlyCause info:eu-repo/grantAgreement/EC/H2020/874739/EU/Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases/LONGITOOLS info:eu-repo/semantics/altIdentifier/pissn/0355-3221 info:eu-repo/semantics/altIdentifier/eissn/1796-2234 info:eu-repo/semantics/openAccess © University of Oulu, 2023 causal mediation child adiposity early life determinants eating behaviours growth trajectories maternal BMI obesity temperament elämän varhaisvaiheiden tekijät kasvun kehityskaaret kausaliteetti lapsen lihavuus lihavuus syömiskäyttäytyminen temperamentti äidin painoindeksi info:eu-repo/semantics/doctoralThesis info:eu-repo/semantics/publishedVersion 2023 ftunivoulu 2023-07-08T20:01:55Z Abstract The obesity epidemic has grown over the last four decades in most European countries including Finland where 21.5% of women and 20% of men are now living with obesity. There is a large body of evidence establishing that the first years of life, including the foetal period, are critical for obesity and general health later in life. However, a better understanding of the link between early life determinants and the life-course trajectory of obesity is needed. In this thesis, associations between early life determinants and cardio-metabolically healthy obesity, defined as obesity in the absence of any cardiometabolic disorders, were investigated. The relationships between early life determinants and developmental body mass index (BMI) trajectories were explored. Finally, the associations between temperament traits and cardiovascular health and whether eating behaviours and fitness mediated the associations were examined. The research was conducted on data from the prospective Northern Finland Birth Cohorts 1966 (NFBC1966) and 1986 (NFBC1986) using association analyses, latent trajectory modelling and causal mediation analysis. The first study suggested that early life determinants such as age at adiposity rebound were associated with cardio-metabolically healthy obesity and that the association differed between males and females. In the second study, developmental BMI trajectories were modelled from NFBC1966 and NFBC1986. Adverse maternal factors were associated with unfavourable BMI trajectories. A different pattern of association between age at adiposity peak and BMI trajectories was found between the different cohorts, uncovering secular trends. The third study provided evidence that associations between temperament traits, established early in life, and cardiovascular health measures could be sex-specific. Furthermore, eating behaviours and mediators involved in the associations seemed to be associated with sex. The research undertaken in this thesis provides evidence to support the effect of early ... Doctoral or Postdoctoral Thesis Northern Finland Jultika - University of Oulu repository |
institution |
Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
causal mediation child adiposity early life determinants eating behaviours growth trajectories maternal BMI obesity temperament elämän varhaisvaiheiden tekijät kasvun kehityskaaret kausaliteetti lapsen lihavuus lihavuus syömiskäyttäytyminen temperamentti äidin painoindeksi |
spellingShingle |
causal mediation child adiposity early life determinants eating behaviours growth trajectories maternal BMI obesity temperament elämän varhaisvaiheiden tekijät kasvun kehityskaaret kausaliteetti lapsen lihavuus lihavuus syömiskäyttäytyminen temperamentti äidin painoindeksi Nedelec, R. (Rozenn) Metabolic health and obesity: early determinants, trajectories and causal analysis:the Northern Finland Birth Cohort 1966 and 1986 studies |
topic_facet |
causal mediation child adiposity early life determinants eating behaviours growth trajectories maternal BMI obesity temperament elämän varhaisvaiheiden tekijät kasvun kehityskaaret kausaliteetti lapsen lihavuus lihavuus syömiskäyttäytyminen temperamentti äidin painoindeksi |
description |
Abstract The obesity epidemic has grown over the last four decades in most European countries including Finland where 21.5% of women and 20% of men are now living with obesity. There is a large body of evidence establishing that the first years of life, including the foetal period, are critical for obesity and general health later in life. However, a better understanding of the link between early life determinants and the life-course trajectory of obesity is needed. In this thesis, associations between early life determinants and cardio-metabolically healthy obesity, defined as obesity in the absence of any cardiometabolic disorders, were investigated. The relationships between early life determinants and developmental body mass index (BMI) trajectories were explored. Finally, the associations between temperament traits and cardiovascular health and whether eating behaviours and fitness mediated the associations were examined. The research was conducted on data from the prospective Northern Finland Birth Cohorts 1966 (NFBC1966) and 1986 (NFBC1986) using association analyses, latent trajectory modelling and causal mediation analysis. The first study suggested that early life determinants such as age at adiposity rebound were associated with cardio-metabolically healthy obesity and that the association differed between males and females. In the second study, developmental BMI trajectories were modelled from NFBC1966 and NFBC1986. Adverse maternal factors were associated with unfavourable BMI trajectories. A different pattern of association between age at adiposity peak and BMI trajectories was found between the different cohorts, uncovering secular trends. The third study provided evidence that associations between temperament traits, established early in life, and cardiovascular health measures could be sex-specific. Furthermore, eating behaviours and mediators involved in the associations seemed to be associated with sex. The research undertaken in this thesis provides evidence to support the effect of early ... |
author2 |
Järvelin, M. (Marjo-Riitta) Miettunen, J. (Jouko) Ruddock, M. (Minna) |
format |
Doctoral or Postdoctoral Thesis |
author |
Nedelec, R. (Rozenn) |
author_facet |
Nedelec, R. (Rozenn) |
author_sort |
Nedelec, R. (Rozenn) |
title |
Metabolic health and obesity: early determinants, trajectories and causal analysis:the Northern Finland Birth Cohort 1966 and 1986 studies |
title_short |
Metabolic health and obesity: early determinants, trajectories and causal analysis:the Northern Finland Birth Cohort 1966 and 1986 studies |
title_full |
Metabolic health and obesity: early determinants, trajectories and causal analysis:the Northern Finland Birth Cohort 1966 and 1986 studies |
title_fullStr |
Metabolic health and obesity: early determinants, trajectories and causal analysis:the Northern Finland Birth Cohort 1966 and 1986 studies |
title_full_unstemmed |
Metabolic health and obesity: early determinants, trajectories and causal analysis:the Northern Finland Birth Cohort 1966 and 1986 studies |
title_sort |
metabolic health and obesity: early determinants, trajectories and causal analysis:the northern finland birth cohort 1966 and 1986 studies |
publisher |
Oulun yliopisto |
publishDate |
2023 |
url |
http://urn.fi/urn:isbn:9789526237008 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
info:eu-repo/grantAgreement/EC/FP7/277849/EU/European ResearcH on DevElopmentAL, BirtH and Genetic Determinants of Ageing/EURHEALTHAGEING info:eu-repo/grantAgreement/EC/H2020/633595/EU/Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging/DYNAHEALTH info:eu-repo/grantAgreement/EC/H2020/733206/EU/Early-life stressors and LifeCycle health/LIFECYCLE info:eu-repo/grantAgreement/EC/H2020/848158/EU/Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity/EarlyCause info:eu-repo/grantAgreement/EC/H2020/874739/EU/Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases/LONGITOOLS info:eu-repo/semantics/altIdentifier/pissn/0355-3221 info:eu-repo/semantics/altIdentifier/eissn/1796-2234 |
op_rights |
info:eu-repo/semantics/openAccess © University of Oulu, 2023 |
_version_ |
1772818000310697984 |