Alcohol use, alcohol polygenic score and cognition in schizophrenia, schizoaffective disorder, bipolar disorder, and a middle-aged birth cohort
Abstract The aim of the study was to investigate the association between alcohol use, alcohol use disorder, and polygenic risk of alcohol use (PGS) and cognition in schizophrenia, schizoaffective disorder, and bipolar disorder. In addition, the association of alcohol use with cognition in the middle...
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2022
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ftunivoulu:oai:oulu.fi:isbn978-952-62-3426-7 2023-07-30T04:05:50+02:00 Alcohol use, alcohol polygenic score and cognition in schizophrenia, schizoaffective disorder, bipolar disorder, and a middle-aged birth cohort Mazumder, A. (Atiqul) Veijola, J. (Juha) Vainio, S. (Seppo) 2022-10-07 application/pdf http://urn.fi/urn:isbn:9789526234267 eng eng Oulun yliopisto info:eu-repo/grantAgreement/EC/H2020/713606/EU/Novel Imaging and Characterisation Methods in Bio, Medical, and Environmental Research and Technology Innovations/I4FUTURE info:eu-repo/semantics/altIdentifier/pissn/0355-3221 info:eu-repo/semantics/altIdentifier/eissn/1796-2234 info:eu-repo/semantics/openAccess © University of Oulu, 2022 alcohol bipolar disorder birth cohort cognition hazardous drinking middle-age polygenic score schizoaffective disorder schizophrenia alkoholi (päihteet) alkoholin riskikäyttö kaksisuuntainen mielialahäiriö keski-ikä kognitio polygeeninen riskipistemäärä skitsoaffektiivinen häiriö skitsofrenia syntymäkohortti info:eu-repo/semantics/doctoralThesis info:eu-repo/semantics/publishedVersion 2022 ftunivoulu 2023-07-08T19:59:45Z Abstract The aim of the study was to investigate the association between alcohol use, alcohol use disorder, and polygenic risk of alcohol use (PGS) and cognition in schizophrenia, schizoaffective disorder, and bipolar disorder. In addition, the association of alcohol use with cognition in the middle-aged birth cohort was investigated. Males and females were examined separately in each study section. In the psychiatric section of the study, the population consisted of 10,417 participants in the SUPER (Finnish Study of the Hereditary Mechanisms of Psychotic Diseases) who had a clinical diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder. In the birth cohort section, the participants were members of the Northern Finland Birth Cohort 1966 (NFBC1966). In the SUPER study, alcohol risk use was screened using the AUDIT-C questionnaire. The alcohol diagnosis was obtained from the health care notification register. PGS was calculated using the LDPred program. In the NFBC1966 birth cohort, alcohol consumption was calculated from the responses to the alcohol use survey. Cognition was assessed in the SUPER study using the reaction time (RT) test to measure reaction time and the Paired Association Learning (PAL) test to measure visual learning and memory. The measures of the RT test were median time and standard deviation, and in the PAL test, memory score and error score. The association of alcohol use with the RT test and the PAL test was analysed using log-linear regression and logistic regression. The association of hazardous drinking PGS with the RT test and the PAL test was analysed using log-linear regression, linear regression, and logistic regression. Only the PAL test was used in the NFBC1966 study. Age, age of onset, educational attainment, household status (marital status), depressive symptoms, diet, and physical activity were used as covariates differently in different sub-studies. The reported risky alcohol use was not associated with poorer cognition in schizophrenia patients and patients ... Doctoral or Postdoctoral Thesis Northern Finland Jultika - University of Oulu repository |
institution |
Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
alcohol bipolar disorder birth cohort cognition hazardous drinking middle-age polygenic score schizoaffective disorder schizophrenia alkoholi (päihteet) alkoholin riskikäyttö kaksisuuntainen mielialahäiriö keski-ikä kognitio polygeeninen riskipistemäärä skitsoaffektiivinen häiriö skitsofrenia syntymäkohortti |
spellingShingle |
alcohol bipolar disorder birth cohort cognition hazardous drinking middle-age polygenic score schizoaffective disorder schizophrenia alkoholi (päihteet) alkoholin riskikäyttö kaksisuuntainen mielialahäiriö keski-ikä kognitio polygeeninen riskipistemäärä skitsoaffektiivinen häiriö skitsofrenia syntymäkohortti Mazumder, A. (Atiqul) Alcohol use, alcohol polygenic score and cognition in schizophrenia, schizoaffective disorder, bipolar disorder, and a middle-aged birth cohort |
topic_facet |
alcohol bipolar disorder birth cohort cognition hazardous drinking middle-age polygenic score schizoaffective disorder schizophrenia alkoholi (päihteet) alkoholin riskikäyttö kaksisuuntainen mielialahäiriö keski-ikä kognitio polygeeninen riskipistemäärä skitsoaffektiivinen häiriö skitsofrenia syntymäkohortti |
description |
Abstract The aim of the study was to investigate the association between alcohol use, alcohol use disorder, and polygenic risk of alcohol use (PGS) and cognition in schizophrenia, schizoaffective disorder, and bipolar disorder. In addition, the association of alcohol use with cognition in the middle-aged birth cohort was investigated. Males and females were examined separately in each study section. In the psychiatric section of the study, the population consisted of 10,417 participants in the SUPER (Finnish Study of the Hereditary Mechanisms of Psychotic Diseases) who had a clinical diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder. In the birth cohort section, the participants were members of the Northern Finland Birth Cohort 1966 (NFBC1966). In the SUPER study, alcohol risk use was screened using the AUDIT-C questionnaire. The alcohol diagnosis was obtained from the health care notification register. PGS was calculated using the LDPred program. In the NFBC1966 birth cohort, alcohol consumption was calculated from the responses to the alcohol use survey. Cognition was assessed in the SUPER study using the reaction time (RT) test to measure reaction time and the Paired Association Learning (PAL) test to measure visual learning and memory. The measures of the RT test were median time and standard deviation, and in the PAL test, memory score and error score. The association of alcohol use with the RT test and the PAL test was analysed using log-linear regression and logistic regression. The association of hazardous drinking PGS with the RT test and the PAL test was analysed using log-linear regression, linear regression, and logistic regression. Only the PAL test was used in the NFBC1966 study. Age, age of onset, educational attainment, household status (marital status), depressive symptoms, diet, and physical activity were used as covariates differently in different sub-studies. The reported risky alcohol use was not associated with poorer cognition in schizophrenia patients and patients ... |
author2 |
Veijola, J. (Juha) Vainio, S. (Seppo) |
format |
Doctoral or Postdoctoral Thesis |
author |
Mazumder, A. (Atiqul) |
author_facet |
Mazumder, A. (Atiqul) |
author_sort |
Mazumder, A. (Atiqul) |
title |
Alcohol use, alcohol polygenic score and cognition in schizophrenia, schizoaffective disorder, bipolar disorder, and a middle-aged birth cohort |
title_short |
Alcohol use, alcohol polygenic score and cognition in schizophrenia, schizoaffective disorder, bipolar disorder, and a middle-aged birth cohort |
title_full |
Alcohol use, alcohol polygenic score and cognition in schizophrenia, schizoaffective disorder, bipolar disorder, and a middle-aged birth cohort |
title_fullStr |
Alcohol use, alcohol polygenic score and cognition in schizophrenia, schizoaffective disorder, bipolar disorder, and a middle-aged birth cohort |
title_full_unstemmed |
Alcohol use, alcohol polygenic score and cognition in schizophrenia, schizoaffective disorder, bipolar disorder, and a middle-aged birth cohort |
title_sort |
alcohol use, alcohol polygenic score and cognition in schizophrenia, schizoaffective disorder, bipolar disorder, and a middle-aged birth cohort |
publisher |
Oulun yliopisto |
publishDate |
2022 |
url |
http://urn.fi/urn:isbn:9789526234267 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
info:eu-repo/grantAgreement/EC/H2020/713606/EU/Novel Imaging and Characterisation Methods in Bio, Medical, and Environmental Research and Technology Innovations/I4FUTURE info:eu-repo/semantics/altIdentifier/pissn/0355-3221 info:eu-repo/semantics/altIdentifier/eissn/1796-2234 |
op_rights |
info:eu-repo/semantics/openAccess © University of Oulu, 2022 |
_version_ |
1772818102676881408 |