Physical activity, vertebral size and lumbar Modic changes in midlife
Abstract Physical activity (PA) influences bone tissue throughout the lifespan and is believed to have a positive effect on vertebral size also during adulthood, thus potentially improving vertebral strength and reducing fracture risk. Modic changes (MC), divided in three subgroups (MC1, MC2, MC3),...
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2021
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ftunivoulu:oai:oulu.fi:isbn978-952-62-3026-9 2023-07-30T04:05:50+02:00 Physical activity, vertebral size and lumbar Modic changes in midlife Modarress Julin, M. M. (Mahsa Marella) Karppinen, J. (Jaro) Korpelainen, R. (Raija) Jämsä, T. (Timo) 2021-10-15 application/pdf http://urn.fi/urn:isbn:9789526230269 eng eng Oulun yliopisto info:eu-repo/semantics/altIdentifier/pissn/0355-3221 info:eu-repo/semantics/altIdentifier/eissn/1796-2234 info:eu-repo/semantics/openAccess © University of Oulu, 2021 Modic changes accelerometry cohort study lumbar spine magnetic resonance imaging physical activity vertebrae vertebral dimensions Modic-muutokset fyysinen aktiivisuus kiihtyvyysanturiin perustuvat fyysisen aktiivisuuden mittausmenetelmät kohorttitutkimus lanneranka magneettikuvaus nikaman koko nikamat info:eu-repo/semantics/doctoralThesis info:eu-repo/semantics/publishedVersion 2021 ftunivoulu 2023-07-08T19:58:45Z Abstract Physical activity (PA) influences bone tissue throughout the lifespan and is believed to have a positive effect on vertebral size also during adulthood, thus potentially improving vertebral strength and reducing fracture risk. Modic changes (MC), divided in three subgroups (MC1, MC2, MC3), are vertebral bone marrow changes visible in magnetic resonance imaging (MRI) that are associated with non-specific low back pain (LBP). This thesis includes three population-based cohort studies (I, II, III) which aim was to investigate the association between device-measured moderate to vigorous intensity PA (MVPA, ≥ 3.5 METs), vertebral cross-sectional area (CSA) (I), and lumbar MC (II), and to determine the relationship between vertebral dimensions and lumbar MC (III), using a subsample (n = 1202–1374) of the Northern Finland Birth Cohort 1966. Participants aged 46 to 48 underwent lumbar MRI from which vertebral dimensions and lumbar MC were assessed, and their daily MVPA was determined by a wrist-worn activity monitor. The results showed that MVPA was positively associated with vertebral CSA among both sexes. Among men, a higher amount of MVPA was associated with increased odds of any lumbar MC, particularly MC2, whereas among women no such association was found. Exploration of the relationship between vertebral dimensions and lumbar MC revealed that vertebral height was positively associated with the presence of lumbar MC2, whereas vertebral CSA and volume were not associated with MC. The results of this thesis propose that MVPA has a positive impact on vertebral size among both sexes at midlife, thus lifelong MVPA might be a preventive action for reducing future vertebral fractures. Lumbar MC seem to be associated with higher vertebrae. MVPA seems to be associated with an increased likelihood of lumbar MC, but only among men and especially with MC2, strengthening the hypothesis that changed mechanical conditions due to hyperloading are connected to MC2. Further studies are needed to verify these findings and to ... Doctoral or Postdoctoral Thesis Northern Finland Jultika - University of Oulu repository |
institution |
Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
Modic changes accelerometry cohort study lumbar spine magnetic resonance imaging physical activity vertebrae vertebral dimensions Modic-muutokset fyysinen aktiivisuus kiihtyvyysanturiin perustuvat fyysisen aktiivisuuden mittausmenetelmät kohorttitutkimus lanneranka magneettikuvaus nikaman koko nikamat |
spellingShingle |
Modic changes accelerometry cohort study lumbar spine magnetic resonance imaging physical activity vertebrae vertebral dimensions Modic-muutokset fyysinen aktiivisuus kiihtyvyysanturiin perustuvat fyysisen aktiivisuuden mittausmenetelmät kohorttitutkimus lanneranka magneettikuvaus nikaman koko nikamat Modarress Julin, M. M. (Mahsa Marella) Physical activity, vertebral size and lumbar Modic changes in midlife |
topic_facet |
Modic changes accelerometry cohort study lumbar spine magnetic resonance imaging physical activity vertebrae vertebral dimensions Modic-muutokset fyysinen aktiivisuus kiihtyvyysanturiin perustuvat fyysisen aktiivisuuden mittausmenetelmät kohorttitutkimus lanneranka magneettikuvaus nikaman koko nikamat |
description |
Abstract Physical activity (PA) influences bone tissue throughout the lifespan and is believed to have a positive effect on vertebral size also during adulthood, thus potentially improving vertebral strength and reducing fracture risk. Modic changes (MC), divided in three subgroups (MC1, MC2, MC3), are vertebral bone marrow changes visible in magnetic resonance imaging (MRI) that are associated with non-specific low back pain (LBP). This thesis includes three population-based cohort studies (I, II, III) which aim was to investigate the association between device-measured moderate to vigorous intensity PA (MVPA, ≥ 3.5 METs), vertebral cross-sectional area (CSA) (I), and lumbar MC (II), and to determine the relationship between vertebral dimensions and lumbar MC (III), using a subsample (n = 1202–1374) of the Northern Finland Birth Cohort 1966. Participants aged 46 to 48 underwent lumbar MRI from which vertebral dimensions and lumbar MC were assessed, and their daily MVPA was determined by a wrist-worn activity monitor. The results showed that MVPA was positively associated with vertebral CSA among both sexes. Among men, a higher amount of MVPA was associated with increased odds of any lumbar MC, particularly MC2, whereas among women no such association was found. Exploration of the relationship between vertebral dimensions and lumbar MC revealed that vertebral height was positively associated with the presence of lumbar MC2, whereas vertebral CSA and volume were not associated with MC. The results of this thesis propose that MVPA has a positive impact on vertebral size among both sexes at midlife, thus lifelong MVPA might be a preventive action for reducing future vertebral fractures. Lumbar MC seem to be associated with higher vertebrae. MVPA seems to be associated with an increased likelihood of lumbar MC, but only among men and especially with MC2, strengthening the hypothesis that changed mechanical conditions due to hyperloading are connected to MC2. Further studies are needed to verify these findings and to ... |
author2 |
Karppinen, J. (Jaro) Korpelainen, R. (Raija) Jämsä, T. (Timo) |
format |
Doctoral or Postdoctoral Thesis |
author |
Modarress Julin, M. M. (Mahsa Marella) |
author_facet |
Modarress Julin, M. M. (Mahsa Marella) |
author_sort |
Modarress Julin, M. M. (Mahsa Marella) |
title |
Physical activity, vertebral size and lumbar Modic changes in midlife |
title_short |
Physical activity, vertebral size and lumbar Modic changes in midlife |
title_full |
Physical activity, vertebral size and lumbar Modic changes in midlife |
title_fullStr |
Physical activity, vertebral size and lumbar Modic changes in midlife |
title_full_unstemmed |
Physical activity, vertebral size and lumbar Modic changes in midlife |
title_sort |
physical activity, vertebral size and lumbar modic changes in midlife |
publisher |
Oulun yliopisto |
publishDate |
2021 |
url |
http://urn.fi/urn:isbn:9789526230269 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
info:eu-repo/semantics/altIdentifier/pissn/0355-3221 info:eu-repo/semantics/altIdentifier/eissn/1796-2234 |
op_rights |
info:eu-repo/semantics/openAccess © University of Oulu, 2021 |
_version_ |
1772818114706145280 |