Long-term consequences of polycystic ovary syndrome on mental health and health-related quality of life
Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women. It affects 9–18% of the female population, but often remains undiagnosed. In addition to the common somatic comorbidities of the syndrome, including decreased fertility and hormonal and metabo...
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2021
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ftunivoulu:oai:oulu.fi:isbn978-952-62-2849-5 2023-07-30T04:05:50+02:00 Long-term consequences of polycystic ovary syndrome on mental health and health-related quality of life Karjula, S. (Salla) Piltonen, T. (Terhi) 2021-02-12 application/pdf http://urn.fi/urn:isbn:9789526228495 eng eng Oulun yliopisto info:eu-repo/semantics/altIdentifier/pissn/0355-3221 info:eu-repo/semantics/altIdentifier/eissn/1796-2234 info:eu-repo/semantics/openAccess © University of Oulu, 2021 aging anxiety depression health-related quality of life hyperandrogenism polycystic ovary syndrome psychological distress psychosis ahdistus hyperandrogenismi ikääntyminen masennus monirakkulainen munasarjaoireyhtymä psykoosit psyykkinen stressi terveyteen liittyvä elämänlaatu info:eu-repo/semantics/doctoralThesis info:eu-repo/semantics/publishedVersion 2021 ftunivoulu 2023-07-08T19:58:22Z Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women. It affects 9–18% of the female population, but often remains undiagnosed. In addition to the common somatic comorbidities of the syndrome, including decreased fertility and hormonal and metabolic issues, there is emerging evidence showing higher risk for psychological distress, especially depression and anxiety, in PCOS. Furthermore, the latest studies indicate an increased prevalence of more severe psychiatric diseases, e.g., schizophrenia, in females with PCOS. Thus, PCOS exerts a severe health burden which decreases the health-related quality of life (HRQoL). Despite increasing interest and research, it is still unclear how the psychological and psychiatric health and HRQoL of women with PCOS are affected through aging up to menopause, as most studies have been conducted on reproductive-aged women. The main aim of this work was to assess the risk for psychological distress and decreased HRQoL in PCOS during two different time points, at age 31 and 46, using data from the prospective longitudinal Northern Finland Birth Cohort 1966 (NFBC66). Additionally, the long-term psychosis risk in women with PCOS was assessed by linking the NFBC66 data with the national registers. The results showed a higher prevalence of anxiety and/or depression symptoms in women with PCOS at both ages. The lifetime risk for depression was nearly 2-fold higher up to age 46. PCOS was also associated with a 3-fold higher risk for psychosis until age 50, even after adjusting for parental history of psychosis, which is the most common risk factor. The affected women showed a lower HRQoL up to age 46, in addition to a decreased health status and life satisfaction. The analyses indicated that the findings could not be explained by overweight, obesity, hyperandrogenism, or infertility. Overall, the findings suggest that PCOS is an independent risk factor for psychological distress up to a late reproductive age. The study showed that ... Doctoral or Postdoctoral Thesis Northern Finland Jultika - University of Oulu repository |
institution |
Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
aging anxiety depression health-related quality of life hyperandrogenism polycystic ovary syndrome psychological distress psychosis ahdistus hyperandrogenismi ikääntyminen masennus monirakkulainen munasarjaoireyhtymä psykoosit psyykkinen stressi terveyteen liittyvä elämänlaatu |
spellingShingle |
aging anxiety depression health-related quality of life hyperandrogenism polycystic ovary syndrome psychological distress psychosis ahdistus hyperandrogenismi ikääntyminen masennus monirakkulainen munasarjaoireyhtymä psykoosit psyykkinen stressi terveyteen liittyvä elämänlaatu Karjula, S. (Salla) Long-term consequences of polycystic ovary syndrome on mental health and health-related quality of life |
topic_facet |
aging anxiety depression health-related quality of life hyperandrogenism polycystic ovary syndrome psychological distress psychosis ahdistus hyperandrogenismi ikääntyminen masennus monirakkulainen munasarjaoireyhtymä psykoosit psyykkinen stressi terveyteen liittyvä elämänlaatu |
description |
Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women. It affects 9–18% of the female population, but often remains undiagnosed. In addition to the common somatic comorbidities of the syndrome, including decreased fertility and hormonal and metabolic issues, there is emerging evidence showing higher risk for psychological distress, especially depression and anxiety, in PCOS. Furthermore, the latest studies indicate an increased prevalence of more severe psychiatric diseases, e.g., schizophrenia, in females with PCOS. Thus, PCOS exerts a severe health burden which decreases the health-related quality of life (HRQoL). Despite increasing interest and research, it is still unclear how the psychological and psychiatric health and HRQoL of women with PCOS are affected through aging up to menopause, as most studies have been conducted on reproductive-aged women. The main aim of this work was to assess the risk for psychological distress and decreased HRQoL in PCOS during two different time points, at age 31 and 46, using data from the prospective longitudinal Northern Finland Birth Cohort 1966 (NFBC66). Additionally, the long-term psychosis risk in women with PCOS was assessed by linking the NFBC66 data with the national registers. The results showed a higher prevalence of anxiety and/or depression symptoms in women with PCOS at both ages. The lifetime risk for depression was nearly 2-fold higher up to age 46. PCOS was also associated with a 3-fold higher risk for psychosis until age 50, even after adjusting for parental history of psychosis, which is the most common risk factor. The affected women showed a lower HRQoL up to age 46, in addition to a decreased health status and life satisfaction. The analyses indicated that the findings could not be explained by overweight, obesity, hyperandrogenism, or infertility. Overall, the findings suggest that PCOS is an independent risk factor for psychological distress up to a late reproductive age. The study showed that ... |
author2 |
Piltonen, T. (Terhi) |
format |
Doctoral or Postdoctoral Thesis |
author |
Karjula, S. (Salla) |
author_facet |
Karjula, S. (Salla) |
author_sort |
Karjula, S. (Salla) |
title |
Long-term consequences of polycystic ovary syndrome on mental health and health-related quality of life |
title_short |
Long-term consequences of polycystic ovary syndrome on mental health and health-related quality of life |
title_full |
Long-term consequences of polycystic ovary syndrome on mental health and health-related quality of life |
title_fullStr |
Long-term consequences of polycystic ovary syndrome on mental health and health-related quality of life |
title_full_unstemmed |
Long-term consequences of polycystic ovary syndrome on mental health and health-related quality of life |
title_sort |
long-term consequences of polycystic ovary syndrome on mental health and health-related quality of life |
publisher |
Oulun yliopisto |
publishDate |
2021 |
url |
http://urn.fi/urn:isbn:9789526228495 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
info:eu-repo/semantics/altIdentifier/pissn/0355-3221 info:eu-repo/semantics/altIdentifier/eissn/1796-2234 |
op_rights |
info:eu-repo/semantics/openAccess © University of Oulu, 2021 |
_version_ |
1772818111782715392 |