Brain white matter structure, body mass index and physical activity in individuals at risk for psychosis:the Northern Finland Birth Cohort 1986 Study
Abstract Recognition of individuals at highest risk for psychosis is challenging and no definitive biomarkers are yet available. Physical illnesses associated with a sedentary lifestyle are common in patients with severe mental illness. Both, bodyweight and risk for psychosis are associated with bra...
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ftunivoulu:oai:oulu.fi:isbn978-952-62-1286-9 2023-07-30T04:05:49+02:00 Brain white matter structure, body mass index and physical activity in individuals at risk for psychosis:the Northern Finland Birth Cohort 1986 Study Koivukangas, J. (Jenni) Veijola, J. (Juha) Tervonen, O. (Osmo) Nikkinen, J. (Juha) 2016-08-19 application/pdf http://urn.fi/urn:isbn:9789526212869 eng eng Oulun yliopisto info:eu-repo/semantics/altIdentifier/pissn/0355-3221 info:eu-repo/semantics/altIdentifier/eissn/1796-2234 info:eu-repo/semantics/openAccess © University of Oulu, 2016 adolescent birth cohort-study body mass index (BMI) diffusion tensor imaging (DTI) exercise physical fitness risk for psychosis white matter young adult diffuusiotensorikuvaus kunto liikunta nuoret aikuiset nuori painoindeksi psykoosialttius syntymäkohorttitutkimus valkea aine info:eu-repo/semantics/doctoralThesis info:eu-repo/semantics/publishedVersion 2016 ftunivoulu 2023-07-08T20:01:28Z Abstract Recognition of individuals at highest risk for psychosis is challenging and no definitive biomarkers are yet available. Physical illnesses associated with a sedentary lifestyle are common in patients with severe mental illness. Both, bodyweight and risk for psychosis are associated with brain white matter (WM) abnormalities. There are several dysregulated pathways which are common in psychiatric illnesses and weight-related processes, but it is not known how weight and vulnerability for psychosis interact in the brain. The present study examines brain WM microstructure and its association to body mass index (BMI) in young adults with a familial risk for psychosis (FR). In addition, the level of physical activity and cardiorespiratory fitness in individuals vulnerable to psychosis was examined. Participants of the present study are members of the Northern Finland Birth Cohort 1986. Two separate clinical substudies were conducted. The first having been done when the participants were at age 15–16. At that time, physical activity was defined by postal questionnaire (n=6,987) and cardiorespiratory fitness was measured by a submaximal cycle ergometer test (n=4,803). Risk for psychosis was viewed from three perspectives, with possible overlap between groups: having familial risk for psychosis, existing prodromal symptoms at age 15–16, and development of hospital treated psychosis between the ages of 16 and 20 years. The latter substudy was conducted when the participants were aged between 20 and 25 years. Diffusion tensor imaging was performed on 108 participants. Our study showed that there was no difference in WM microstructure between FR and control groups suggesting that WM abnormalities are not a genetic feature for risk of psychosis in all populations. However, the association between BMI and WM microstructure differed significantly between the FR and control groups. We also demonstrated that the level of physical activity was lower before the onset of psychotic illness. Therefore, these results imply ... Doctoral or Postdoctoral Thesis Northern Finland Jultika - University of Oulu repository Aine ENVELOPE(16.883,16.883,65.950,65.950) |
institution |
Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
adolescent birth cohort-study body mass index (BMI) diffusion tensor imaging (DTI) exercise physical fitness risk for psychosis white matter young adult diffuusiotensorikuvaus kunto liikunta nuoret aikuiset nuori painoindeksi psykoosialttius syntymäkohorttitutkimus valkea aine |
spellingShingle |
adolescent birth cohort-study body mass index (BMI) diffusion tensor imaging (DTI) exercise physical fitness risk for psychosis white matter young adult diffuusiotensorikuvaus kunto liikunta nuoret aikuiset nuori painoindeksi psykoosialttius syntymäkohorttitutkimus valkea aine Koivukangas, J. (Jenni) Brain white matter structure, body mass index and physical activity in individuals at risk for psychosis:the Northern Finland Birth Cohort 1986 Study |
topic_facet |
adolescent birth cohort-study body mass index (BMI) diffusion tensor imaging (DTI) exercise physical fitness risk for psychosis white matter young adult diffuusiotensorikuvaus kunto liikunta nuoret aikuiset nuori painoindeksi psykoosialttius syntymäkohorttitutkimus valkea aine |
description |
Abstract Recognition of individuals at highest risk for psychosis is challenging and no definitive biomarkers are yet available. Physical illnesses associated with a sedentary lifestyle are common in patients with severe mental illness. Both, bodyweight and risk for psychosis are associated with brain white matter (WM) abnormalities. There are several dysregulated pathways which are common in psychiatric illnesses and weight-related processes, but it is not known how weight and vulnerability for psychosis interact in the brain. The present study examines brain WM microstructure and its association to body mass index (BMI) in young adults with a familial risk for psychosis (FR). In addition, the level of physical activity and cardiorespiratory fitness in individuals vulnerable to psychosis was examined. Participants of the present study are members of the Northern Finland Birth Cohort 1986. Two separate clinical substudies were conducted. The first having been done when the participants were at age 15–16. At that time, physical activity was defined by postal questionnaire (n=6,987) and cardiorespiratory fitness was measured by a submaximal cycle ergometer test (n=4,803). Risk for psychosis was viewed from three perspectives, with possible overlap between groups: having familial risk for psychosis, existing prodromal symptoms at age 15–16, and development of hospital treated psychosis between the ages of 16 and 20 years. The latter substudy was conducted when the participants were aged between 20 and 25 years. Diffusion tensor imaging was performed on 108 participants. Our study showed that there was no difference in WM microstructure between FR and control groups suggesting that WM abnormalities are not a genetic feature for risk of psychosis in all populations. However, the association between BMI and WM microstructure differed significantly between the FR and control groups. We also demonstrated that the level of physical activity was lower before the onset of psychotic illness. Therefore, these results imply ... |
author2 |
Veijola, J. (Juha) Tervonen, O. (Osmo) Nikkinen, J. (Juha) |
format |
Doctoral or Postdoctoral Thesis |
author |
Koivukangas, J. (Jenni) |
author_facet |
Koivukangas, J. (Jenni) |
author_sort |
Koivukangas, J. (Jenni) |
title |
Brain white matter structure, body mass index and physical activity in individuals at risk for psychosis:the Northern Finland Birth Cohort 1986 Study |
title_short |
Brain white matter structure, body mass index and physical activity in individuals at risk for psychosis:the Northern Finland Birth Cohort 1986 Study |
title_full |
Brain white matter structure, body mass index and physical activity in individuals at risk for psychosis:the Northern Finland Birth Cohort 1986 Study |
title_fullStr |
Brain white matter structure, body mass index and physical activity in individuals at risk for psychosis:the Northern Finland Birth Cohort 1986 Study |
title_full_unstemmed |
Brain white matter structure, body mass index and physical activity in individuals at risk for psychosis:the Northern Finland Birth Cohort 1986 Study |
title_sort |
brain white matter structure, body mass index and physical activity in individuals at risk for psychosis:the northern finland birth cohort 1986 study |
publisher |
Oulun yliopisto |
publishDate |
2016 |
url |
http://urn.fi/urn:isbn:9789526212869 |
long_lat |
ENVELOPE(16.883,16.883,65.950,65.950) |
geographic |
Aine |
geographic_facet |
Aine |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
info:eu-repo/semantics/altIdentifier/pissn/0355-3221 info:eu-repo/semantics/altIdentifier/eissn/1796-2234 |
op_rights |
info:eu-repo/semantics/openAccess © University of Oulu, 2016 |
_version_ |
1772818012440625152 |