Resting state brain networks in young people with familial risk for psychosis
Abstract Neuropsychiatric illnesses usually become overtly manifest in adolescence and early adulthood. A critical long-term aim is to be able to prevent the development of such illnesses, which requires instruments to identify subjects at high risk of illness and to offer them effective interventio...
Main Author: | |
---|---|
Other Authors: | , |
Format: | Doctoral or Postdoctoral Thesis |
Language: | English |
Published: |
Oulun yliopisto
2016
|
Subjects: | |
Online Access: | http://urn.fi/urn:isbn:9789526211107 |
id |
ftunivoulu:oai:oulu.fi:isbn978-952-62-1110-7 |
---|---|
record_format |
openpolar |
spelling |
ftunivoulu:oai:oulu.fi:isbn978-952-62-1110-7 2023-07-30T04:05:50+02:00 Resting state brain networks in young people with familial risk for psychosis Jukuri, T. (Tuomas) Veijola, J. (Juha) Kiviniemi, V. (Vesa) 2016-02-16 application/pdf http://urn.fi/urn:isbn:9789526211107 eng eng Oulun yliopisto info:eu-repo/semantics/altIdentifier/pissn/0355-3221 info:eu-repo/semantics/altIdentifier/eissn/1796-2234 info:eu-repo/semantics/openAccess © University of Oulu, 2016 BOLD-signal CEN DMN PCC R-fMRI anterior lobe of the right cerebellum birth cohort central executive network cerebellum default mode network fMRI familial risk for psychosis functional MRI genetic vulnerability independent component analysis parental psychosis posterior cingulate cortex rIFG resting-state right inferior frontal gyrus schizophrenia BOLD-signaali ICA itsenäisten komponenttien analyysi oletushermoverkko pikkuaivot psykoosialttius skitsofrenia syntymäkohortti toiminnanohjauksesta vastaava hermoverkko info:eu-repo/semantics/doctoralThesis info:eu-repo/semantics/publishedVersion 2016 ftunivoulu 2023-07-08T19:53:32Z Abstract Neuropsychiatric illnesses usually become overtly manifest in adolescence and early adulthood. A critical long-term aim is to be able to prevent the development of such illnesses, which requires instruments to identify subjects at high risk of illness and to offer them effective interventions. There is an indisputable need for more sophisticated methods to enable more precise detection of adolescents and young adults who are at high risk of developing psychosis. Abnormal function in brain networks has been reported in people with schizophrenia and other psychotic disorders. Similar abnormalities have been found also in people at risk for developing psychosis, but it is not known whether this applies also to spontaneous resting state activity in young people with a familial risk for psychosis. We conducted resting-state functional MRI (R-fMRI) in 72 (29 male) young adults with a history of psychosis in one or both parents (FR) but without psychosis themselves, and 72 (29 male) similarly healthy control subjects without familial risk for psychosis. Both groups in the Oulu Brain and Mind study were drawn from the Northern Finland Birth Cohort 1986. All volunteers were 20–25 years old. Parental psychosis was established using the Care Register for Health Care. R-fMRI data was pre-processed using independent component analysis (ICA). A dual regression technique was used to detect between-group differences with p < 0.05 threshold corrected for multiple comparisons at voxel level. FR subjects demonstrated significantly decreased activity compared to control subjects in the default mode network and in the central executive network and increased activity in the cerebellum. The findings clarify previously controversial literature on the subject. The finding suggests that abnormal activity in these brain networks in rest may be associated with increased vulnerability to psychosis. The findings maybe helpful in developing more precise methods for detecting young people at highest risk for developing psychosis. ... Doctoral or Postdoctoral Thesis Northern Finland Jultika - University of Oulu repository |
institution |
Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
BOLD-signal CEN DMN PCC R-fMRI anterior lobe of the right cerebellum birth cohort central executive network cerebellum default mode network fMRI familial risk for psychosis functional MRI genetic vulnerability independent component analysis parental psychosis posterior cingulate cortex rIFG resting-state right inferior frontal gyrus schizophrenia BOLD-signaali ICA itsenäisten komponenttien analyysi oletushermoverkko pikkuaivot psykoosialttius skitsofrenia syntymäkohortti toiminnanohjauksesta vastaava hermoverkko |
spellingShingle |
BOLD-signal CEN DMN PCC R-fMRI anterior lobe of the right cerebellum birth cohort central executive network cerebellum default mode network fMRI familial risk for psychosis functional MRI genetic vulnerability independent component analysis parental psychosis posterior cingulate cortex rIFG resting-state right inferior frontal gyrus schizophrenia BOLD-signaali ICA itsenäisten komponenttien analyysi oletushermoverkko pikkuaivot psykoosialttius skitsofrenia syntymäkohortti toiminnanohjauksesta vastaava hermoverkko Jukuri, T. (Tuomas) Resting state brain networks in young people with familial risk for psychosis |
topic_facet |
BOLD-signal CEN DMN PCC R-fMRI anterior lobe of the right cerebellum birth cohort central executive network cerebellum default mode network fMRI familial risk for psychosis functional MRI genetic vulnerability independent component analysis parental psychosis posterior cingulate cortex rIFG resting-state right inferior frontal gyrus schizophrenia BOLD-signaali ICA itsenäisten komponenttien analyysi oletushermoverkko pikkuaivot psykoosialttius skitsofrenia syntymäkohortti toiminnanohjauksesta vastaava hermoverkko |
description |
Abstract Neuropsychiatric illnesses usually become overtly manifest in adolescence and early adulthood. A critical long-term aim is to be able to prevent the development of such illnesses, which requires instruments to identify subjects at high risk of illness and to offer them effective interventions. There is an indisputable need for more sophisticated methods to enable more precise detection of adolescents and young adults who are at high risk of developing psychosis. Abnormal function in brain networks has been reported in people with schizophrenia and other psychotic disorders. Similar abnormalities have been found also in people at risk for developing psychosis, but it is not known whether this applies also to spontaneous resting state activity in young people with a familial risk for psychosis. We conducted resting-state functional MRI (R-fMRI) in 72 (29 male) young adults with a history of psychosis in one or both parents (FR) but without psychosis themselves, and 72 (29 male) similarly healthy control subjects without familial risk for psychosis. Both groups in the Oulu Brain and Mind study were drawn from the Northern Finland Birth Cohort 1986. All volunteers were 20–25 years old. Parental psychosis was established using the Care Register for Health Care. R-fMRI data was pre-processed using independent component analysis (ICA). A dual regression technique was used to detect between-group differences with p < 0.05 threshold corrected for multiple comparisons at voxel level. FR subjects demonstrated significantly decreased activity compared to control subjects in the default mode network and in the central executive network and increased activity in the cerebellum. The findings clarify previously controversial literature on the subject. The finding suggests that abnormal activity in these brain networks in rest may be associated with increased vulnerability to psychosis. The findings maybe helpful in developing more precise methods for detecting young people at highest risk for developing psychosis. ... |
author2 |
Veijola, J. (Juha) Kiviniemi, V. (Vesa) |
format |
Doctoral or Postdoctoral Thesis |
author |
Jukuri, T. (Tuomas) |
author_facet |
Jukuri, T. (Tuomas) |
author_sort |
Jukuri, T. (Tuomas) |
title |
Resting state brain networks in young people with familial risk for psychosis |
title_short |
Resting state brain networks in young people with familial risk for psychosis |
title_full |
Resting state brain networks in young people with familial risk for psychosis |
title_fullStr |
Resting state brain networks in young people with familial risk for psychosis |
title_full_unstemmed |
Resting state brain networks in young people with familial risk for psychosis |
title_sort |
resting state brain networks in young people with familial risk for psychosis |
publisher |
Oulun yliopisto |
publishDate |
2016 |
url |
http://urn.fi/urn:isbn:9789526211107 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
info:eu-repo/semantics/altIdentifier/pissn/0355-3221 info:eu-repo/semantics/altIdentifier/eissn/1796-2234 |
op_rights |
info:eu-repo/semantics/openAccess © University of Oulu, 2016 |
_version_ |
1772818117360091136 |