Diagnostics and determinants of schizophrenia:the Northern Finland 1966 Birth Cohort Study
Abstract The Northern Finland 1966 Birth Cohort is an unselected, population-based sample of 12,058 live born children. The present study is based on 10,934 individuals living in Finland at the age of 16 years. Ninety-six research diagnoses fulfilling operational DSM-III-R criteria for schizophrenia...
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2011
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ftunivoulu:oai:oulu.fi:isbn978-951-42-9612-3 2023-07-30T04:05:49+02:00 Diagnostics and determinants of schizophrenia:the Northern Finland 1966 Birth Cohort Study Moilanen, K. (Kristiina) Isohanni, M. (Matti) Koivumaa-Honkanen, H. (Heli) 2011-11-18 application/pdf http://urn.fi/urn:isbn:9789514296123 eng eng Oulun yliopisto info:eu-repo/semantics/altIdentifier/pissn/0355-3221 info:eu-repo/semantics/altIdentifier/eissn/1796-2234 info:eu-repo/semantics/openAccess © University of Oulu, 2011 birth cohort birth length birth weight diagnostic accuracy motor milestones other psychosis schizophrenia unwantedness of pregnancy diagnostiikan osuvuus muut psykoosit skitsofrenia syntymäkohortti syntymäpaino syntymäpituus varhaislapsuuden kehitys info:eu-repo/semantics/doctoralThesis info:eu-repo/semantics/publishedVersion 2011 ftunivoulu 2023-07-08T20:01:22Z Abstract The Northern Finland 1966 Birth Cohort is an unselected, population-based sample of 12,058 live born children. The present study is based on 10,934 individuals living in Finland at the age of 16 years. Ninety-six research diagnoses fulfilling operational DSM-III-R criteria for schizophrenia by age 34 years were found in the reassessment of clinical diagnoses. Of these 96 cases, 55 (57%) had concordant diagnoses (both the clinical and research diagnosis was schizophrenia) and 41 (43%) had discordant diagnoses (the clinical diagnosis was other than schizophrenia). Diagnostic discordance was associated with low parental social class in 1980, later age at onset, comorbid diagnosis of mental retardation, shorter treatment periods and lower number of treatment episodes. Unwanted pregnancy and parental history of psychosis increased the risk for schizophrenia. The combination of unwantedness of pregnancy and parental history of psychosis elevated the risk of schizophrenia over 8-fold in offspring compared to those without either risk factor. Both low and high birth weight increased the risk of later schizophrenia. Both short and tall babies also had elevated risk. A reverse J-shape curve described the associations between birth weight, length and schizophrenia. The ages when cohort members learned to stand, walk and became potty-trained were related to subsequent incidence of schizophrenia and other psychoses. Earlier milestones reduced and later milestones increased the risk in a linear manner. In conclusion, these results indicate that schizophrenia has complex phenomenology and developmental pathways. Its multiple symptomatology with no single specific defining feature and no absolute validation criteria makes the phenomenological-based diagnosis of schizophrenia challenging. Unwanted pregnancy may act as an additive factor for subjects already vulnerable to schizophrenia and psychoses may have a developmental dimension expressed as deviant foetal development and delayed milestones. These results support ... Doctoral or Postdoctoral Thesis Northern Finland Jultika - University of Oulu repository |
institution |
Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
birth cohort birth length birth weight diagnostic accuracy motor milestones other psychosis schizophrenia unwantedness of pregnancy diagnostiikan osuvuus muut psykoosit skitsofrenia syntymäkohortti syntymäpaino syntymäpituus varhaislapsuuden kehitys |
spellingShingle |
birth cohort birth length birth weight diagnostic accuracy motor milestones other psychosis schizophrenia unwantedness of pregnancy diagnostiikan osuvuus muut psykoosit skitsofrenia syntymäkohortti syntymäpaino syntymäpituus varhaislapsuuden kehitys Moilanen, K. (Kristiina) Diagnostics and determinants of schizophrenia:the Northern Finland 1966 Birth Cohort Study |
topic_facet |
birth cohort birth length birth weight diagnostic accuracy motor milestones other psychosis schizophrenia unwantedness of pregnancy diagnostiikan osuvuus muut psykoosit skitsofrenia syntymäkohortti syntymäpaino syntymäpituus varhaislapsuuden kehitys |
description |
Abstract The Northern Finland 1966 Birth Cohort is an unselected, population-based sample of 12,058 live born children. The present study is based on 10,934 individuals living in Finland at the age of 16 years. Ninety-six research diagnoses fulfilling operational DSM-III-R criteria for schizophrenia by age 34 years were found in the reassessment of clinical diagnoses. Of these 96 cases, 55 (57%) had concordant diagnoses (both the clinical and research diagnosis was schizophrenia) and 41 (43%) had discordant diagnoses (the clinical diagnosis was other than schizophrenia). Diagnostic discordance was associated with low parental social class in 1980, later age at onset, comorbid diagnosis of mental retardation, shorter treatment periods and lower number of treatment episodes. Unwanted pregnancy and parental history of psychosis increased the risk for schizophrenia. The combination of unwantedness of pregnancy and parental history of psychosis elevated the risk of schizophrenia over 8-fold in offspring compared to those without either risk factor. Both low and high birth weight increased the risk of later schizophrenia. Both short and tall babies also had elevated risk. A reverse J-shape curve described the associations between birth weight, length and schizophrenia. The ages when cohort members learned to stand, walk and became potty-trained were related to subsequent incidence of schizophrenia and other psychoses. Earlier milestones reduced and later milestones increased the risk in a linear manner. In conclusion, these results indicate that schizophrenia has complex phenomenology and developmental pathways. Its multiple symptomatology with no single specific defining feature and no absolute validation criteria makes the phenomenological-based diagnosis of schizophrenia challenging. Unwanted pregnancy may act as an additive factor for subjects already vulnerable to schizophrenia and psychoses may have a developmental dimension expressed as deviant foetal development and delayed milestones. These results support ... |
author2 |
Isohanni, M. (Matti) Koivumaa-Honkanen, H. (Heli) |
format |
Doctoral or Postdoctoral Thesis |
author |
Moilanen, K. (Kristiina) |
author_facet |
Moilanen, K. (Kristiina) |
author_sort |
Moilanen, K. (Kristiina) |
title |
Diagnostics and determinants of schizophrenia:the Northern Finland 1966 Birth Cohort Study |
title_short |
Diagnostics and determinants of schizophrenia:the Northern Finland 1966 Birth Cohort Study |
title_full |
Diagnostics and determinants of schizophrenia:the Northern Finland 1966 Birth Cohort Study |
title_fullStr |
Diagnostics and determinants of schizophrenia:the Northern Finland 1966 Birth Cohort Study |
title_full_unstemmed |
Diagnostics and determinants of schizophrenia:the Northern Finland 1966 Birth Cohort Study |
title_sort |
diagnostics and determinants of schizophrenia:the northern finland 1966 birth cohort study |
publisher |
Oulun yliopisto |
publishDate |
2011 |
url |
http://urn.fi/urn:isbn:9789514296123 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
info:eu-repo/semantics/altIdentifier/pissn/0355-3221 info:eu-repo/semantics/altIdentifier/eissn/1796-2234 |
op_rights |
info:eu-repo/semantics/openAccess © University of Oulu, 2011 |
_version_ |
1772818005267316736 |