Maternal thyroid function during pregnancy:effects on pregnancy, peri- and neonatal outcome and on later maternal health
Abstract Maternal thyroid dysfunction and/or antibodies are present in 5–10% of pregnancies and may be associated with increased risks of adverse pregnancy and perinatal outcomes. In the present study maternal thyroid function and antibody status in the Northern Finland Birth Cohort 1986 was analyze...
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Oulun yliopisto
2011
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ftunivoulu:oai:oulu.fi:isbn978-951-42-9403-7 2023-07-30T04:05:50+02:00 Maternal thyroid function during pregnancy:effects on pregnancy, peri- and neonatal outcome and on later maternal health Männistö, T. (Tuija) Suvanto, E. (Eila) Pouta, A. (Anneli) Järvelin, M. (Marjo-Riitta) 2011-04-05 application/pdf http://urn.fi/urn:isbn:9789514294037 eng eng Oulun yliopisto info:eu-repo/semantics/altIdentifier/pissn/0355-3221 info:eu-repo/semantics/altIdentifier/eissn/1796-2234 info:eu-repo/semantics/openAccess © University of Oulu, 2011 Thyroid - diseases Thyroid gland Thyroid hormones Thyroiditis autoimmune infant morbidity newborn pregnancy reference values kilpirauhanen - sairaudet kilpirauhanen - toiminta raskaus sairastavuus vastasyntynyt viitearvot info:eu-repo/semantics/doctoralThesis info:eu-repo/semantics/publishedVersion 2011 ftunivoulu 2023-07-08T20:01:37Z Abstract Maternal thyroid dysfunction and/or antibodies are present in 5–10% of pregnancies and may be associated with increased risks of adverse pregnancy and perinatal outcomes. In the present study maternal thyroid function and antibody status in the Northern Finland Birth Cohort 1986 was analyzed using early pregnancy serum samples. The impact of long-term storage on the stability of thyroid hormones and antibodies was studied and while TSH and thyroid hormone levels were not affected by storage time the concentrations of thyroid antibodies appeared to be significantly increased after 10 years of storage. Normal maternal thyroid function was evaluated by calculating thyroid hormone reference intervals in the thyroid antibody-negative population using a biobank of stored serum samples. Thyrotropin, free thyroxine and triiodothyronine reference intervals in the first and second trimester were 0.07–3.1 mU/L and 0.10–3.5 mU/L, 11.4–22.4 pmol/L and 11–18.9 pmol/L; and 3.4–7.0 pmol/L and 3.5–7.3 pmol/L, respectively, in this population (Abbott Architect method). Compared with thyroid antibody-negative mothers, antibody-positive mothers had significantly higher TSH and lower fT4 concentrations and an increased risk of experiencing death of an infant in the perinatal period with odds ratios (ORs) of 3.1 (95% confidence interval 1.4–7.1) for thyroid-peroxidase and OR 2.6 (1.1–6.2) for thyroglobulin antibody positivity. These infants were more often born very preterm, which could possibly explain these increased risks. Positive thyroid antibody status was not associated with preterm birth in this study. No other major pregnancy or perinatal complications were observed among mothers or newborns of mothers with thyroid dysfunction/antibodies. Mothers, who had hypothyroidism or thyroid antibodies during pregnancy, had a very high risk of subsequent thyroid disease: hazard ratio (HR) 17.7 (7.8–40.6) for overt hypothyroidism, 4.2 (2.3–7.4) for thyroid-peroxidase and 3.3 (1.9–6.0) for thyroglobulin antibody positivity. ... Doctoral or Postdoctoral Thesis Northern Finland Jultika - University of Oulu repository Abbott ENVELOPE(-62.133,-62.133,-64.100,-64.100) |
institution |
Open Polar |
collection |
Jultika - University of Oulu repository |
op_collection_id |
ftunivoulu |
language |
English |
topic |
Thyroid - diseases Thyroid gland Thyroid hormones Thyroiditis autoimmune infant morbidity newborn pregnancy reference values kilpirauhanen - sairaudet kilpirauhanen - toiminta raskaus sairastavuus vastasyntynyt viitearvot |
spellingShingle |
Thyroid - diseases Thyroid gland Thyroid hormones Thyroiditis autoimmune infant morbidity newborn pregnancy reference values kilpirauhanen - sairaudet kilpirauhanen - toiminta raskaus sairastavuus vastasyntynyt viitearvot Männistö, T. (Tuija) Maternal thyroid function during pregnancy:effects on pregnancy, peri- and neonatal outcome and on later maternal health |
topic_facet |
Thyroid - diseases Thyroid gland Thyroid hormones Thyroiditis autoimmune infant morbidity newborn pregnancy reference values kilpirauhanen - sairaudet kilpirauhanen - toiminta raskaus sairastavuus vastasyntynyt viitearvot |
description |
Abstract Maternal thyroid dysfunction and/or antibodies are present in 5–10% of pregnancies and may be associated with increased risks of adverse pregnancy and perinatal outcomes. In the present study maternal thyroid function and antibody status in the Northern Finland Birth Cohort 1986 was analyzed using early pregnancy serum samples. The impact of long-term storage on the stability of thyroid hormones and antibodies was studied and while TSH and thyroid hormone levels were not affected by storage time the concentrations of thyroid antibodies appeared to be significantly increased after 10 years of storage. Normal maternal thyroid function was evaluated by calculating thyroid hormone reference intervals in the thyroid antibody-negative population using a biobank of stored serum samples. Thyrotropin, free thyroxine and triiodothyronine reference intervals in the first and second trimester were 0.07–3.1 mU/L and 0.10–3.5 mU/L, 11.4–22.4 pmol/L and 11–18.9 pmol/L; and 3.4–7.0 pmol/L and 3.5–7.3 pmol/L, respectively, in this population (Abbott Architect method). Compared with thyroid antibody-negative mothers, antibody-positive mothers had significantly higher TSH and lower fT4 concentrations and an increased risk of experiencing death of an infant in the perinatal period with odds ratios (ORs) of 3.1 (95% confidence interval 1.4–7.1) for thyroid-peroxidase and OR 2.6 (1.1–6.2) for thyroglobulin antibody positivity. These infants were more often born very preterm, which could possibly explain these increased risks. Positive thyroid antibody status was not associated with preterm birth in this study. No other major pregnancy or perinatal complications were observed among mothers or newborns of mothers with thyroid dysfunction/antibodies. Mothers, who had hypothyroidism or thyroid antibodies during pregnancy, had a very high risk of subsequent thyroid disease: hazard ratio (HR) 17.7 (7.8–40.6) for overt hypothyroidism, 4.2 (2.3–7.4) for thyroid-peroxidase and 3.3 (1.9–6.0) for thyroglobulin antibody positivity. ... |
author2 |
Suvanto, E. (Eila) Pouta, A. (Anneli) Järvelin, M. (Marjo-Riitta) |
format |
Doctoral or Postdoctoral Thesis |
author |
Männistö, T. (Tuija) |
author_facet |
Männistö, T. (Tuija) |
author_sort |
Männistö, T. (Tuija) |
title |
Maternal thyroid function during pregnancy:effects on pregnancy, peri- and neonatal outcome and on later maternal health |
title_short |
Maternal thyroid function during pregnancy:effects on pregnancy, peri- and neonatal outcome and on later maternal health |
title_full |
Maternal thyroid function during pregnancy:effects on pregnancy, peri- and neonatal outcome and on later maternal health |
title_fullStr |
Maternal thyroid function during pregnancy:effects on pregnancy, peri- and neonatal outcome and on later maternal health |
title_full_unstemmed |
Maternal thyroid function during pregnancy:effects on pregnancy, peri- and neonatal outcome and on later maternal health |
title_sort |
maternal thyroid function during pregnancy:effects on pregnancy, peri- and neonatal outcome and on later maternal health |
publisher |
Oulun yliopisto |
publishDate |
2011 |
url |
http://urn.fi/urn:isbn:9789514294037 |
long_lat |
ENVELOPE(-62.133,-62.133,-64.100,-64.100) |
geographic |
Abbott |
geographic_facet |
Abbott |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
info:eu-repo/semantics/altIdentifier/pissn/0355-3221 info:eu-repo/semantics/altIdentifier/eissn/1796-2234 |
op_rights |
info:eu-repo/semantics/openAccess © University of Oulu, 2011 |
_version_ |
1772818110961680384 |