Reexamination of the Structure and Function of Lactate Dehydrogenase from Temperate and Antarctic Fish

• Main Author: Kumar, Abhishek
• Other Authors: Marshall, Craig, Krause, Kurt
• Format: Thesis
• Language: English
• Published: University of Otago 2014
• Subjects: Lactate Dehydrogenase; Enzyme Kinetic; Antarctica; Crystallography; Antarctic; Holo; Antarc*; spiny dogfish
• Online Access: http://hdl.handle.net/10523/5115

Studies of cold adaptation in lactate dehydrogenase (LDH) implicated structural rearrangements of the molecule associated with substrate and cofactor binding. Analysis of these regions suggests that these movements are much smaller than previously thought and unlikely to play a key role in adapting...