Detection and quantitation of benzo(a)pyrene-DNA adducts in brain and liver tissues of Beluga whales (Delphinapterus leucas) from the St. Lawrence and Mackenzie Estuaries

• Main Author: Shugart, L. R.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Oak Ridge National Laboratory 1988
• Subjects: Aquatic Organisms; Aromatics; Mutations; Dna Adducts; Mammals; Hydrocarbons; Genes; 63 Radiation; Thermal; And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat; Animals; Adducts; Organic Compounds; Vertebrates 560300* > Chemicals Metabolism & Toxicology; Condensed Aromatics; Bioassay; Benzopyrene; Gene Mutations; Toxicity; Biological Pathways; Cetaceans; Beluga; Beluga*; Delphinapterus leucas
• Online Access: https://digital.library.unt.edu/ark:/67531/metadc1187926/

It should be noted that there are few analytical techniques available for the detection and quantitation of chemical adducts in the DNA of living organisms. The reasons for this are: the analytical technique often has to accommodate the unique chemical and/or physical properties of the individual chemical or its metabolite; the percentage of total chemical that becomes most of the parent compound is usually detoxified and excreted; not all adducts that form between the genotoxic agent and DNA are stable or are involved in the development of subsequent deleterious events in the organism; and the amount of DNA available for analysis is often quite limited. 16 refs., 1 tab.