No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder.
Item does not contain fulltext The Autism Genome Project (AGP) Consortium recently reported genome-wide significant association between autism and an intronic single nucleotide polymorphism marker, rs4141463, within the MACROD2 gene. In the present study we attempted to replicate this finding using...
Published in: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | unknown |
Published: |
2011
|
Subjects: | |
Online Access: | http://hdl.handle.net/2066/98150 https://doi.org/10.1002/ajmg.b.31201 |
id |
ftunivnijmegen:oai:repository.ubn.ru.nl:2066/98150 |
---|---|
record_format |
openpolar |
spelling |
ftunivnijmegen:oai:repository.ubn.ru.nl:2066/98150 2023-12-03T10:24:55+01:00 No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder. Curran, S. Bolton, P. Rozsnyai, K. Chiocchetti, A. Klauck, S.M. Duketis, E. Poustka, F. Schlitt, S. Freitag, C.M. Lee, I. van der Muglia, P. Poot, M. Staal, W.G. Jonge, M.V. de Ophoff, R.A. Lewis, C. Skuse, D. Mandy, W. Vassos, E. Fossdal, R. Magnusson, P. Hreidarsson, S. Saemundsen, E. Stefansson, H. Stefansson, K. Collier, D. 2011 http://hdl.handle.net/2066/98150 https://doi.org/10.1002/ajmg.b.31201 unknown http://hdl.handle.net/2066/98150 doi:10.1002/ajmg.b.31201 American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, 156B, 6, pp. 633-9 DCN 2: Functional Neurogenomics Article / Letter to editor 2011 ftunivnijmegen https://doi.org/10.1002/ajmg.b.31201 2023-11-08T23:09:15Z Item does not contain fulltext The Autism Genome Project (AGP) Consortium recently reported genome-wide significant association between autism and an intronic single nucleotide polymorphism marker, rs4141463, within the MACROD2 gene. In the present study we attempted to replicate this finding using an independent case-control design of 1,170 cases with autism spectrum disorder (ASD) (874 of which fulfilled narrow criteria for Autism (A)) from five centers within Europe (UK, Germany, the Netherlands, Italy, and Iceland), and 35,307 controls. The combined sample size gave us a non-centrality parameter (NCP) of 11.9, with 93% power to detect allelic association of rs4141463 at an alpha of 0.05 with odds ratio of 0.84 (the best odds ratio estimate of the AGP Consortium data), and for the narrow diagnosis of autism, an NCP of 8.9 and power of 85%. Our case-control data were analyzed for association, stratified by each center, and the summary statistics were combined using the meta-analysis program, GWAMA. This resulted in an odds ratio (OR) of 1.03 (95% CI 0.944-1.133), with a P-value of 0.5 for ASD and OR of 0.99 (95% CI 0.88-1.11) with P-value = 0.85 for the Autism (A) sub-group. Therefore, this study does not provide support for the reported association between rs4141463 and autism. 01 september 2011 Article in Journal/Newspaper Iceland Radboud University: DSpace American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156 6 633 639 |
institution |
Open Polar |
collection |
Radboud University: DSpace |
op_collection_id |
ftunivnijmegen |
language |
unknown |
topic |
DCN 2: Functional Neurogenomics |
spellingShingle |
DCN 2: Functional Neurogenomics Curran, S. Bolton, P. Rozsnyai, K. Chiocchetti, A. Klauck, S.M. Duketis, E. Poustka, F. Schlitt, S. Freitag, C.M. Lee, I. van der Muglia, P. Poot, M. Staal, W.G. Jonge, M.V. de Ophoff, R.A. Lewis, C. Skuse, D. Mandy, W. Vassos, E. Fossdal, R. Magnusson, P. Hreidarsson, S. Saemundsen, E. Stefansson, H. Stefansson, K. Collier, D. No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder. |
topic_facet |
DCN 2: Functional Neurogenomics |
description |
Item does not contain fulltext The Autism Genome Project (AGP) Consortium recently reported genome-wide significant association between autism and an intronic single nucleotide polymorphism marker, rs4141463, within the MACROD2 gene. In the present study we attempted to replicate this finding using an independent case-control design of 1,170 cases with autism spectrum disorder (ASD) (874 of which fulfilled narrow criteria for Autism (A)) from five centers within Europe (UK, Germany, the Netherlands, Italy, and Iceland), and 35,307 controls. The combined sample size gave us a non-centrality parameter (NCP) of 11.9, with 93% power to detect allelic association of rs4141463 at an alpha of 0.05 with odds ratio of 0.84 (the best odds ratio estimate of the AGP Consortium data), and for the narrow diagnosis of autism, an NCP of 8.9 and power of 85%. Our case-control data were analyzed for association, stratified by each center, and the summary statistics were combined using the meta-analysis program, GWAMA. This resulted in an odds ratio (OR) of 1.03 (95% CI 0.944-1.133), with a P-value of 0.5 for ASD and OR of 0.99 (95% CI 0.88-1.11) with P-value = 0.85 for the Autism (A) sub-group. Therefore, this study does not provide support for the reported association between rs4141463 and autism. 01 september 2011 |
format |
Article in Journal/Newspaper |
author |
Curran, S. Bolton, P. Rozsnyai, K. Chiocchetti, A. Klauck, S.M. Duketis, E. Poustka, F. Schlitt, S. Freitag, C.M. Lee, I. van der Muglia, P. Poot, M. Staal, W.G. Jonge, M.V. de Ophoff, R.A. Lewis, C. Skuse, D. Mandy, W. Vassos, E. Fossdal, R. Magnusson, P. Hreidarsson, S. Saemundsen, E. Stefansson, H. Stefansson, K. Collier, D. |
author_facet |
Curran, S. Bolton, P. Rozsnyai, K. Chiocchetti, A. Klauck, S.M. Duketis, E. Poustka, F. Schlitt, S. Freitag, C.M. Lee, I. van der Muglia, P. Poot, M. Staal, W.G. Jonge, M.V. de Ophoff, R.A. Lewis, C. Skuse, D. Mandy, W. Vassos, E. Fossdal, R. Magnusson, P. Hreidarsson, S. Saemundsen, E. Stefansson, H. Stefansson, K. Collier, D. |
author_sort |
Curran, S. |
title |
No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder. |
title_short |
No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder. |
title_full |
No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder. |
title_fullStr |
No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder. |
title_full_unstemmed |
No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder. |
title_sort |
no association between a common single nucleotide polymorphism, rs4141463, in the macrod2 gene and autism spectrum disorder. |
publishDate |
2011 |
url |
http://hdl.handle.net/2066/98150 https://doi.org/10.1002/ajmg.b.31201 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, 156B, 6, pp. 633-9 |
op_relation |
http://hdl.handle.net/2066/98150 doi:10.1002/ajmg.b.31201 |
op_doi |
https://doi.org/10.1002/ajmg.b.31201 |
container_title |
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
container_volume |
156 |
container_issue |
6 |
container_start_page |
633 |
op_container_end_page |
639 |
_version_ |
1784273512823783424 |