Regulatory and pathogenetic mechanisms of autoantibodies in SLE
Contains fulltext : 96275.pdf (publisher's version ) (Closed access) In the 53 years since the discovery of anti-DNA autoantibodies in lupus [1, 2, 3] , recalcitrant questions have been pondered and possible answers have been debated. The discovery of anti-DNA autoantibodies presented many puzz...
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ftunivnijmegen:oai:repository.ubn.ru.nl:2066/96275 2023-05-15T15:05:07+02:00 Regulatory and pathogenetic mechanisms of autoantibodies in SLE Radic, M. Herrmann, M. Vlag, J. van der Rekvig, O.P. 2011 http://hdl.handle.net/2066/96275 https://doi.org/10.3109/08916934.20https://doi.org/10.536794 unknown http://hdl.handle.net/2066/96275 https://doi.org/10.3109/08916934.20https://doi.org/10.536794 Autoimmunity, 44, 5, pp. 349-56 NCMLS 3: Tissue engineering and pathology N4i 4: Auto-immunity transplantation and immunotherapy Article / Letter to editor 2011 ftunivnijmegen https://doi.org/10.3109/08916934.20https://doi.org/10.536794 2022-09-29T05:44:43Z Contains fulltext : 96275.pdf (publisher's version ) (Closed access) In the 53 years since the discovery of anti-DNA autoantibodies in lupus [1, 2, 3] , recalcitrant questions have been pondered and possible answers have been debated. The discovery of anti-DNA autoantibodies presented many puzzles: How is immunological tolerance to native B-form DNA broken? What elicits characteristic systemic lupus erythematosus (SLE) autoantibodies? Which of the diverse anti-nuclear reactivities are pathogenic? What is the role of autoantibodies in the clinical presentation of disease? How do genetic predisposition and environmental triggers contribute to SLE? These questions were brought into focus by Professor David Stollar in an introductory presentation to an intense, three-day meeting set among the rugged and inspiring scenery of the Norwegian arctic coastline (the Scientific Program is included as supplemental File 1). Other participants presented and discussed topics directed to understanding the origin and clinico-pathological impact of autoantibodies to chromatin and phospholipid antigens. In the following, several aspects of the workshop are discussed. Article in Journal/Newspaper Arctic Radboud University: DSpace Arctic Autoimmunity 44 5 349 356 |
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Radboud University: DSpace |
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ftunivnijmegen |
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NCMLS 3: Tissue engineering and pathology N4i 4: Auto-immunity transplantation and immunotherapy |
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NCMLS 3: Tissue engineering and pathology N4i 4: Auto-immunity transplantation and immunotherapy Radic, M. Herrmann, M. Vlag, J. van der Rekvig, O.P. Regulatory and pathogenetic mechanisms of autoantibodies in SLE |
topic_facet |
NCMLS 3: Tissue engineering and pathology N4i 4: Auto-immunity transplantation and immunotherapy |
description |
Contains fulltext : 96275.pdf (publisher's version ) (Closed access) In the 53 years since the discovery of anti-DNA autoantibodies in lupus [1, 2, 3] , recalcitrant questions have been pondered and possible answers have been debated. The discovery of anti-DNA autoantibodies presented many puzzles: How is immunological tolerance to native B-form DNA broken? What elicits characteristic systemic lupus erythematosus (SLE) autoantibodies? Which of the diverse anti-nuclear reactivities are pathogenic? What is the role of autoantibodies in the clinical presentation of disease? How do genetic predisposition and environmental triggers contribute to SLE? These questions were brought into focus by Professor David Stollar in an introductory presentation to an intense, three-day meeting set among the rugged and inspiring scenery of the Norwegian arctic coastline (the Scientific Program is included as supplemental File 1). Other participants presented and discussed topics directed to understanding the origin and clinico-pathological impact of autoantibodies to chromatin and phospholipid antigens. In the following, several aspects of the workshop are discussed. |
format |
Article in Journal/Newspaper |
author |
Radic, M. Herrmann, M. Vlag, J. van der Rekvig, O.P. |
author_facet |
Radic, M. Herrmann, M. Vlag, J. van der Rekvig, O.P. |
author_sort |
Radic, M. |
title |
Regulatory and pathogenetic mechanisms of autoantibodies in SLE |
title_short |
Regulatory and pathogenetic mechanisms of autoantibodies in SLE |
title_full |
Regulatory and pathogenetic mechanisms of autoantibodies in SLE |
title_fullStr |
Regulatory and pathogenetic mechanisms of autoantibodies in SLE |
title_full_unstemmed |
Regulatory and pathogenetic mechanisms of autoantibodies in SLE |
title_sort |
regulatory and pathogenetic mechanisms of autoantibodies in sle |
publishDate |
2011 |
url |
http://hdl.handle.net/2066/96275 https://doi.org/10.3109/08916934.20https://doi.org/10.536794 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Autoimmunity, 44, 5, pp. 349-56 |
op_relation |
http://hdl.handle.net/2066/96275 https://doi.org/10.3109/08916934.20https://doi.org/10.536794 |
op_doi |
https://doi.org/10.3109/08916934.20https://doi.org/10.536794 |
container_title |
Autoimmunity |
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44 |
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5 |
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349 |
op_container_end_page |
356 |
_version_ |
1766336873324609536 |