Effects of the Synthetic Corticosteroid Prednisolone on the Growth and Osmoregulatory Physiology of Atlantic Salmon (Salmo salar)
The smolting process that many anadromous salmonids undergo prior to migration is largely mediated by release of the corticosteroid cortisol, which serves to alter osmoregulatory physiology and prepare the fish to move from freshwater into seawater. The synthetic corticosteroid prednisolone mimics t...
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ftunivnewhaven:oai:digitalcommons.newhaven.edu:masterstheses-1117 2023-05-15T15:31:04+02:00 Effects of the Synthetic Corticosteroid Prednisolone on the Growth and Osmoregulatory Physiology of Atlantic Salmon (Salmo salar) Kalinowski, Matt C. 2019-05-01T07:00:00Z application/pdf https://digitalcommons.newhaven.edu/masterstheses/116 https://digitalcommons.newhaven.edu/cgi/viewcontent.cgi?article=1117&context=masterstheses unknown Digital Commons @ New Haven https://digitalcommons.newhaven.edu/masterstheses/116 https://digitalcommons.newhaven.edu/cgi/viewcontent.cgi?article=1117&context=masterstheses Master's Theses Biology Ecology and Evolutionary Biology Marine Biology text 2019 ftunivnewhaven 2022-07-10T14:26:34Z The smolting process that many anadromous salmonids undergo prior to migration is largely mediated by release of the corticosteroid cortisol, which serves to alter osmoregulatory physiology and prepare the fish to move from freshwater into seawater. The synthetic corticosteroid prednisolone mimics the effects of cortisol and is widely used as a potent antiinflammatory medication. Prednisolone has been detected in measurable concentrations of some freshwater systems. It is possible that environmental concentrations of prednisolone may negatively impact salmonids, by altering parr physiology or interfering with secondary measures of performances associated with smoltification. Forty-eight Atlantic salmon parr of similar length (10.1 cm fork length, SD = 0.5) were split into four groups of 12 fish and individually PIT tagged. Treatments consisted of implantation of hormones dissolved in vegetable oil: a) 2.5 μg/g prednisolone, b) 25 μg/g prednisolone, c) 25 μg/g cortisol, or d) vegetable oil (control). Fish were held for 22 days in two mixed group holding tanks, at ambient temperatures and natural day length, and fed ad libitum. Individuals were sacrificed, measured (length/weight), and gill filaments, plasma, and liver samples were collected. Concentrations of plasma chloride, glucose and cortisol, gill NKA activity, hematocrit, and overall growth rate were determined. Suppression of growth was observed with 25 μg/g prednisolone and 25 μg/g cortisol. Increase in Igfbp-1a1 mRNA expression was observed in the 25 μg/g prednisolone treatment. Plasma chloride was significantly higher in the 25 μg/g prednisolone treatment compared to the control. Results indicated that exposure of Atlantic salmon parr to prednisolone had a significant effect on growth and osmoregulation, suggesting that this hormone may act as an endocrine disrupting chemical in the aquatic environment. Text Atlantic salmon Salmo salar University of New Haven: Digital Commons @ New Haven |
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Open Polar |
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University of New Haven: Digital Commons @ New Haven |
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ftunivnewhaven |
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unknown |
topic |
Biology Ecology and Evolutionary Biology Marine Biology |
spellingShingle |
Biology Ecology and Evolutionary Biology Marine Biology Kalinowski, Matt C. Effects of the Synthetic Corticosteroid Prednisolone on the Growth and Osmoregulatory Physiology of Atlantic Salmon (Salmo salar) |
topic_facet |
Biology Ecology and Evolutionary Biology Marine Biology |
description |
The smolting process that many anadromous salmonids undergo prior to migration is largely mediated by release of the corticosteroid cortisol, which serves to alter osmoregulatory physiology and prepare the fish to move from freshwater into seawater. The synthetic corticosteroid prednisolone mimics the effects of cortisol and is widely used as a potent antiinflammatory medication. Prednisolone has been detected in measurable concentrations of some freshwater systems. It is possible that environmental concentrations of prednisolone may negatively impact salmonids, by altering parr physiology or interfering with secondary measures of performances associated with smoltification. Forty-eight Atlantic salmon parr of similar length (10.1 cm fork length, SD = 0.5) were split into four groups of 12 fish and individually PIT tagged. Treatments consisted of implantation of hormones dissolved in vegetable oil: a) 2.5 μg/g prednisolone, b) 25 μg/g prednisolone, c) 25 μg/g cortisol, or d) vegetable oil (control). Fish were held for 22 days in two mixed group holding tanks, at ambient temperatures and natural day length, and fed ad libitum. Individuals were sacrificed, measured (length/weight), and gill filaments, plasma, and liver samples were collected. Concentrations of plasma chloride, glucose and cortisol, gill NKA activity, hematocrit, and overall growth rate were determined. Suppression of growth was observed with 25 μg/g prednisolone and 25 μg/g cortisol. Increase in Igfbp-1a1 mRNA expression was observed in the 25 μg/g prednisolone treatment. Plasma chloride was significantly higher in the 25 μg/g prednisolone treatment compared to the control. Results indicated that exposure of Atlantic salmon parr to prednisolone had a significant effect on growth and osmoregulation, suggesting that this hormone may act as an endocrine disrupting chemical in the aquatic environment. |
format |
Text |
author |
Kalinowski, Matt C. |
author_facet |
Kalinowski, Matt C. |
author_sort |
Kalinowski, Matt C. |
title |
Effects of the Synthetic Corticosteroid Prednisolone on the Growth and Osmoregulatory Physiology of Atlantic Salmon (Salmo salar) |
title_short |
Effects of the Synthetic Corticosteroid Prednisolone on the Growth and Osmoregulatory Physiology of Atlantic Salmon (Salmo salar) |
title_full |
Effects of the Synthetic Corticosteroid Prednisolone on the Growth and Osmoregulatory Physiology of Atlantic Salmon (Salmo salar) |
title_fullStr |
Effects of the Synthetic Corticosteroid Prednisolone on the Growth and Osmoregulatory Physiology of Atlantic Salmon (Salmo salar) |
title_full_unstemmed |
Effects of the Synthetic Corticosteroid Prednisolone on the Growth and Osmoregulatory Physiology of Atlantic Salmon (Salmo salar) |
title_sort |
effects of the synthetic corticosteroid prednisolone on the growth and osmoregulatory physiology of atlantic salmon (salmo salar) |
publisher |
Digital Commons @ New Haven |
publishDate |
2019 |
url |
https://digitalcommons.newhaven.edu/masterstheses/116 https://digitalcommons.newhaven.edu/cgi/viewcontent.cgi?article=1117&context=masterstheses |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Master's Theses |
op_relation |
https://digitalcommons.newhaven.edu/masterstheses/116 https://digitalcommons.newhaven.edu/cgi/viewcontent.cgi?article=1117&context=masterstheses |
_version_ |
1766361551218933760 |