Facial phenotyping by quantitative photography reflects craniofacial morphology measured on magnetic resonance imaging in Icelandic sleep apnea patients
Study Objectives: (1) To determine whether facial phenotype, measured by quantitative photography, relates to underlying craniofacial obstructive sleep apnea (OSA) risk factors, measured with magnetic resonance imaging (MRI); (2) To assess whether these associations are independent of body size and...
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ftunivnewcastnsw:uon:18863 2023-05-15T16:51:52+02:00 Facial phenotyping by quantitative photography reflects craniofacial morphology measured on magnetic resonance imaging in Icelandic sleep apnea patients Sutherland, Kate Schwab, Richard J. Maislin, Greg Lee, Richard W. W. Benedikstdsottir, Bryndis Pack, Allan I. Gislason, Thorarinn Juliusson, Sigurdur Cistulli, Peter A. The University of Newcastle. Faculty of Health & Medicine, School of Medicine and Public Health 2014 http://hdl.handle.net/1959.13/1294772 eng eng Associated Professional Sleep Societies NIH.P01 HL094307 Sleep Vol. 37, Issue 5, p. 959-968 10.5665/sleep.3670 craniofacial morphology obstructive sleep apnea phenotyping journal article 2014 ftunivnewcastnsw 2018-07-27T00:46:27Z Study Objectives: (1) To determine whether facial phenotype, measured by quantitative photography, relates to underlying craniofacial obstructive sleep apnea (OSA) risk factors, measured with magnetic resonance imaging (MRI); (2) To assess whether these associations are independent of body size and obesity. Design: Cross-sectional cohort. Setting: Landspitali, The National University Hospital, Iceland. Participants: One hundred forty patients (87.1% male) from the Icelandic Sleep Apnea Cohort who had both calibrated frontal and profile craniofacial photographs and upper airway MRI. Mean ± standard deviation age 56.1 ± 10.4 y, body mass index 33.5 ± 5.05 kg/m 2 , with on-average severe OSA (apnea-hypopnea index 45.4 ± 19.7 h -1 ). Interventions: N/A. Measurements and Results: Relationships between surface facial dimensions (photos) and facial bony dimensions and upper airway soft-tissue volumes (MRI) was assessed using canonical correlation analysis. Photo and MRI craniofacial datasets related in four significant canonical correlations, primarily driven by measurements of (1) maxillary-mandibular relationship (r = 0.8, P < 0.0001), (2) lower face height (r = 0.76, P < 0.0001), (3) mandibular length (r = 0.67, P < 0.0001), and (4) tongue volume (r = 0.52, P = 0.01). Correlations 1, 2, and 3 were unchanged when controlled for weight and neck and waist circumference. However, tongue volume was no longer significant, suggesting facial dimensions relate to tongue volume as a result of obesity. Conclusions: Significant associations were found between craniofacial variable sets from facial photography and MRI. This study confirms that facial photographic phenotype reflects underlying aspects of craniofacial skeletal abnormalities associated with OSA. Therefore, facial photographic phenotyping may be a useful tool to assess intermediate phenotypes for OSA, particularly in large-scale studies. Article in Journal/Newspaper Iceland NOVA: The University of Newcastle Research Online (Australia) |
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Open Polar |
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NOVA: The University of Newcastle Research Online (Australia) |
op_collection_id |
ftunivnewcastnsw |
language |
English |
topic |
craniofacial morphology obstructive sleep apnea phenotyping |
spellingShingle |
craniofacial morphology obstructive sleep apnea phenotyping Sutherland, Kate Schwab, Richard J. Maislin, Greg Lee, Richard W. W. Benedikstdsottir, Bryndis Pack, Allan I. Gislason, Thorarinn Juliusson, Sigurdur Cistulli, Peter A. Facial phenotyping by quantitative photography reflects craniofacial morphology measured on magnetic resonance imaging in Icelandic sleep apnea patients |
topic_facet |
craniofacial morphology obstructive sleep apnea phenotyping |
description |
Study Objectives: (1) To determine whether facial phenotype, measured by quantitative photography, relates to underlying craniofacial obstructive sleep apnea (OSA) risk factors, measured with magnetic resonance imaging (MRI); (2) To assess whether these associations are independent of body size and obesity. Design: Cross-sectional cohort. Setting: Landspitali, The National University Hospital, Iceland. Participants: One hundred forty patients (87.1% male) from the Icelandic Sleep Apnea Cohort who had both calibrated frontal and profile craniofacial photographs and upper airway MRI. Mean ± standard deviation age 56.1 ± 10.4 y, body mass index 33.5 ± 5.05 kg/m 2 , with on-average severe OSA (apnea-hypopnea index 45.4 ± 19.7 h -1 ). Interventions: N/A. Measurements and Results: Relationships between surface facial dimensions (photos) and facial bony dimensions and upper airway soft-tissue volumes (MRI) was assessed using canonical correlation analysis. Photo and MRI craniofacial datasets related in four significant canonical correlations, primarily driven by measurements of (1) maxillary-mandibular relationship (r = 0.8, P < 0.0001), (2) lower face height (r = 0.76, P < 0.0001), (3) mandibular length (r = 0.67, P < 0.0001), and (4) tongue volume (r = 0.52, P = 0.01). Correlations 1, 2, and 3 were unchanged when controlled for weight and neck and waist circumference. However, tongue volume was no longer significant, suggesting facial dimensions relate to tongue volume as a result of obesity. Conclusions: Significant associations were found between craniofacial variable sets from facial photography and MRI. This study confirms that facial photographic phenotype reflects underlying aspects of craniofacial skeletal abnormalities associated with OSA. Therefore, facial photographic phenotyping may be a useful tool to assess intermediate phenotypes for OSA, particularly in large-scale studies. |
author2 |
The University of Newcastle. Faculty of Health & Medicine, School of Medicine and Public Health |
format |
Article in Journal/Newspaper |
author |
Sutherland, Kate Schwab, Richard J. Maislin, Greg Lee, Richard W. W. Benedikstdsottir, Bryndis Pack, Allan I. Gislason, Thorarinn Juliusson, Sigurdur Cistulli, Peter A. |
author_facet |
Sutherland, Kate Schwab, Richard J. Maislin, Greg Lee, Richard W. W. Benedikstdsottir, Bryndis Pack, Allan I. Gislason, Thorarinn Juliusson, Sigurdur Cistulli, Peter A. |
author_sort |
Sutherland, Kate |
title |
Facial phenotyping by quantitative photography reflects craniofacial morphology measured on magnetic resonance imaging in Icelandic sleep apnea patients |
title_short |
Facial phenotyping by quantitative photography reflects craniofacial morphology measured on magnetic resonance imaging in Icelandic sleep apnea patients |
title_full |
Facial phenotyping by quantitative photography reflects craniofacial morphology measured on magnetic resonance imaging in Icelandic sleep apnea patients |
title_fullStr |
Facial phenotyping by quantitative photography reflects craniofacial morphology measured on magnetic resonance imaging in Icelandic sleep apnea patients |
title_full_unstemmed |
Facial phenotyping by quantitative photography reflects craniofacial morphology measured on magnetic resonance imaging in Icelandic sleep apnea patients |
title_sort |
facial phenotyping by quantitative photography reflects craniofacial morphology measured on magnetic resonance imaging in icelandic sleep apnea patients |
publisher |
Associated Professional Sleep Societies |
publishDate |
2014 |
url |
http://hdl.handle.net/1959.13/1294772 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
NIH.P01 HL094307 Sleep Vol. 37, Issue 5, p. 959-968 10.5665/sleep.3670 |
_version_ |
1766041994027597824 |