CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020
The development of new approaches to prevent microbial surface adhesion and biofilm formation is an emerging need following the growing understanding of the impact of biofilm-related infections on human health. Staphylococcus epidermidis, with its ability to form biofilm and colonize biomaterials, r...
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Online Access: | https://hdl.handle.net/11588/907812 https://doi.org/10.3390/md20120747 |
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ftunivnapoliiris:oai:www.iris.unina.it:11588/907812 2024-04-14T08:04:15+00:00 CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 Caterina D’Angelo Angela Casillo Chiara Melchiorre Concetta Lauro Maria Michela Corsaro Andrea Carpentieri Maria Luisa Tutino Ermenegilda Parrilli D'Angelo, Caterina Casillo, Angela Melchiorre, Chiara Lauro, Concetta Corsaro, MARIA MICHELA Carpentieri, Andrea Tutino, MARIA LUISA Parrilli, Ermenegilda 2022 https://hdl.handle.net/11588/907812 https://doi.org/10.3390/md20120747 eng ita eng ita info:eu-repo/semantics/altIdentifier/wos/WOS:000901328500001 volume:20 issue:12 firstpage:747 journal:MARINE DRUGS https://hdl.handle.net/11588/907812 doi:10.3390/md20120747 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85144530906 info:eu-repo/semantics/openAccess info:eu-repo/semantics/article 2022 ftunivnapoliiris https://doi.org/10.3390/md20120747 2024-03-21T18:50:13Z The development of new approaches to prevent microbial surface adhesion and biofilm formation is an emerging need following the growing understanding of the impact of biofilm-related infections on human health. Staphylococcus epidermidis, with its ability to form biofilm and colonize biomaterials, represents the most frequent causative agent involved in infections of medical devices. In the research of new anti-biofilm agents against S. epidermidis biofilm, Antarctic marine bacteria represent an untapped reservoir of biodiversity. In the present study, the attention was focused on Psychrobacter sp. TAE2020, an Antarctic marine bacterium that produces molecules able to impair the initial attachment of S. epidermidis strains to the polystyrene surface. The setup of suitable purification protocols allowed the identification by NMR spectroscopy and LC-MS/MS analysis of a protein–polysaccharide complex named CATASAN. This complex proved to be a very effective anti-biofilm agent. Indeed, it not only interferes with cell surface attachment, but also prevents biofilm formation and affects the mature biofilm matrix structure of S. epidermidis. Moreover, CATASAN is endowed with a good emulsification activity in a wide range of pH and temperature. Therefore, its use can be easily extended to different biotechnological applications. Article in Journal/Newspaper Antarc* Antarctic IRIS Università degli Studi di Napoli Federico II Antarctic Marine Drugs 20 12 747 |
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Open Polar |
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IRIS Università degli Studi di Napoli Federico II |
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ftunivnapoliiris |
language |
English Italian |
description |
The development of new approaches to prevent microbial surface adhesion and biofilm formation is an emerging need following the growing understanding of the impact of biofilm-related infections on human health. Staphylococcus epidermidis, with its ability to form biofilm and colonize biomaterials, represents the most frequent causative agent involved in infections of medical devices. In the research of new anti-biofilm agents against S. epidermidis biofilm, Antarctic marine bacteria represent an untapped reservoir of biodiversity. In the present study, the attention was focused on Psychrobacter sp. TAE2020, an Antarctic marine bacterium that produces molecules able to impair the initial attachment of S. epidermidis strains to the polystyrene surface. The setup of suitable purification protocols allowed the identification by NMR spectroscopy and LC-MS/MS analysis of a protein–polysaccharide complex named CATASAN. This complex proved to be a very effective anti-biofilm agent. Indeed, it not only interferes with cell surface attachment, but also prevents biofilm formation and affects the mature biofilm matrix structure of S. epidermidis. Moreover, CATASAN is endowed with a good emulsification activity in a wide range of pH and temperature. Therefore, its use can be easily extended to different biotechnological applications. |
author2 |
D'Angelo, Caterina Casillo, Angela Melchiorre, Chiara Lauro, Concetta Corsaro, MARIA MICHELA Carpentieri, Andrea Tutino, MARIA LUISA Parrilli, Ermenegilda |
format |
Article in Journal/Newspaper |
author |
Caterina D’Angelo Angela Casillo Chiara Melchiorre Concetta Lauro Maria Michela Corsaro Andrea Carpentieri Maria Luisa Tutino Ermenegilda Parrilli |
spellingShingle |
Caterina D’Angelo Angela Casillo Chiara Melchiorre Concetta Lauro Maria Michela Corsaro Andrea Carpentieri Maria Luisa Tutino Ermenegilda Parrilli CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
author_facet |
Caterina D’Angelo Angela Casillo Chiara Melchiorre Concetta Lauro Maria Michela Corsaro Andrea Carpentieri Maria Luisa Tutino Ermenegilda Parrilli |
author_sort |
Caterina D’Angelo |
title |
CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
title_short |
CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
title_full |
CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
title_fullStr |
CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
title_full_unstemmed |
CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
title_sort |
catasan is a new anti-biofilm agent produced by the marine antarctic bacterium psychrobacter sp. tae2020 |
publishDate |
2022 |
url |
https://hdl.handle.net/11588/907812 https://doi.org/10.3390/md20120747 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
info:eu-repo/semantics/altIdentifier/wos/WOS:000901328500001 volume:20 issue:12 firstpage:747 journal:MARINE DRUGS https://hdl.handle.net/11588/907812 doi:10.3390/md20120747 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85144530906 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3390/md20120747 |
container_title |
Marine Drugs |
container_volume |
20 |
container_issue |
12 |
container_start_page |
747 |
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1796300691609747456 |