Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis
Staphylococcus epidermidis, a harmless human skin colonizer, is a significant nosocomial pathogen in predisposed hosts because of its capability to form a biofilm on indwelling medical devices. In a recent paper, the purification and identification of the pentadecanal produced by the Antarctic bacte...
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Online Access: | http://hdl.handle.net/11588/732292 https://doi.org/10.1080/08927014.2018.1544246 |
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ftunivnapoliiris:oai:www.iris.unina.it:11588/732292 2024-09-09T19:09:39+00:00 Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis Ricciardelli, Annarita Casillo, Angela Papa, Rosanna Monti, Daria Maria Imbimbo, Paola Vrenna, Gianluca Artini, Marco Selan, Laura Corsaro, Maria Michela Tutino, Maria Luisa Parrilli, Ermenegilda Ricciardelli, Annarita Casillo, Angela Papa, Rosanna Monti, Daria Maria Imbimbo, Paola Vrenna, Gianluca Artini, Marco Selan, Laura Corsaro, Maria Michela Tutino, Maria Luisa Parrilli, Ermenegilda 2018 http://hdl.handle.net/11588/732292 https://doi.org/10.1080/08927014.2018.1544246 eng eng info:eu-repo/semantics/altIdentifier/wos/WOS:000461979400003 volume:34 issue:10 firstpage:1 lastpage:11 numberofpages:11 journal:BIOFOULING http://hdl.handle.net/11588/732292 doi:10.1080/08927014.2018.1544246 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85060959115 info:eu-repo/semantics/restrictedAccess TAC125 1,1-dimethoxypentadecane Anti-biofilm pentadecanal pentadecanoic acid pentadecanoic acid methyl ester vancomycin info:eu-repo/semantics/article 2018 ftunivnapoliiris https://doi.org/10.1080/08927014.2018.1544246 2024-06-17T15:19:33Z Staphylococcus epidermidis, a harmless human skin colonizer, is a significant nosocomial pathogen in predisposed hosts because of its capability to form a biofilm on indwelling medical devices. In a recent paper, the purification and identification of the pentadecanal produced by the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125, able to impair S. epidermidis biofilm formation, were reported. Here the authors report on the chemical synthesis of pentadecanal derivatives, their anti-biofilm activity on S. epidermidis, and their action in combination with antibiotics. The results clearly indicate that the pentadecanal derivatives were able to prevent, to a different extent, biofilm formation and that pentadecanoic acid positively modulated the antimicrobial activity of the vancomycin. The cytotoxicity of these new anti-biofilm molecules was tested on two different immortalized eukaryotic cell lines in view of their potential applications. Article in Journal/Newspaper Antarc* Antarctic IRIS Università degli Studi di Napoli Federico II Antarctic The Antarctic Biofouling 34 10 1110 1120 |
institution |
Open Polar |
collection |
IRIS Università degli Studi di Napoli Federico II |
op_collection_id |
ftunivnapoliiris |
language |
English |
topic |
TAC125 1,1-dimethoxypentadecane Anti-biofilm pentadecanal pentadecanoic acid pentadecanoic acid methyl ester vancomycin |
spellingShingle |
TAC125 1,1-dimethoxypentadecane Anti-biofilm pentadecanal pentadecanoic acid pentadecanoic acid methyl ester vancomycin Ricciardelli, Annarita Casillo, Angela Papa, Rosanna Monti, Daria Maria Imbimbo, Paola Vrenna, Gianluca Artini, Marco Selan, Laura Corsaro, Maria Michela Tutino, Maria Luisa Parrilli, Ermenegilda Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis |
topic_facet |
TAC125 1,1-dimethoxypentadecane Anti-biofilm pentadecanal pentadecanoic acid pentadecanoic acid methyl ester vancomycin |
description |
Staphylococcus epidermidis, a harmless human skin colonizer, is a significant nosocomial pathogen in predisposed hosts because of its capability to form a biofilm on indwelling medical devices. In a recent paper, the purification and identification of the pentadecanal produced by the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125, able to impair S. epidermidis biofilm formation, were reported. Here the authors report on the chemical synthesis of pentadecanal derivatives, their anti-biofilm activity on S. epidermidis, and their action in combination with antibiotics. The results clearly indicate that the pentadecanal derivatives were able to prevent, to a different extent, biofilm formation and that pentadecanoic acid positively modulated the antimicrobial activity of the vancomycin. The cytotoxicity of these new anti-biofilm molecules was tested on two different immortalized eukaryotic cell lines in view of their potential applications. |
author2 |
Ricciardelli, Annarita Casillo, Angela Papa, Rosanna Monti, Daria Maria Imbimbo, Paola Vrenna, Gianluca Artini, Marco Selan, Laura Corsaro, Maria Michela Tutino, Maria Luisa Parrilli, Ermenegilda |
format |
Article in Journal/Newspaper |
author |
Ricciardelli, Annarita Casillo, Angela Papa, Rosanna Monti, Daria Maria Imbimbo, Paola Vrenna, Gianluca Artini, Marco Selan, Laura Corsaro, Maria Michela Tutino, Maria Luisa Parrilli, Ermenegilda |
author_facet |
Ricciardelli, Annarita Casillo, Angela Papa, Rosanna Monti, Daria Maria Imbimbo, Paola Vrenna, Gianluca Artini, Marco Selan, Laura Corsaro, Maria Michela Tutino, Maria Luisa Parrilli, Ermenegilda |
author_sort |
Ricciardelli, Annarita |
title |
Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis |
title_short |
Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis |
title_full |
Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis |
title_fullStr |
Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis |
title_full_unstemmed |
Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis |
title_sort |
pentadecanal inspired molecules as new anti-biofilm agents against staphylococcus epidermidis |
publishDate |
2018 |
url |
http://hdl.handle.net/11588/732292 https://doi.org/10.1080/08927014.2018.1544246 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
info:eu-repo/semantics/altIdentifier/wos/WOS:000461979400003 volume:34 issue:10 firstpage:1 lastpage:11 numberofpages:11 journal:BIOFOULING http://hdl.handle.net/11588/732292 doi:10.1080/08927014.2018.1544246 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85060959115 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1080/08927014.2018.1544246 |
container_title |
Biofouling |
container_volume |
34 |
container_issue |
10 |
container_start_page |
1110 |
op_container_end_page |
1120 |
_version_ |
1809823896716705792 |