Polymerization of hemoglobins in Arctic fish: Lycodes reticulatus and Gadus morhua.

In vitro, and possibly in vivo, hemoglobin polymerization and red blood cell sickling appear to be widespread in codfish. In this article, we show that the hemoglobins of the two Arctic fish Lycodes reticulatus and Gadus morhua also have the tendency to polymerize, as monitored by dynamic light scat...

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Published in:IUBMB Life
Main Authors: Riccio A, Giordano D, Flagiello A, Tedesco R, Bruno S, di Prisco G, Verde C., MANGIAPIA, GAETANO, VERGARA, ALESSANDRO, MAZZARELLA, LELIO, PUCCI, PIETRO, PADUANO, LUIGI
Other Authors: Riccio, A, Mangiapia, Gaetano, Giordano, D, Flagiello, A, Tedesco, R, Bruno, S, Vergara, Alessandro, Mazzarella, Lelio, di Prisco, G, Pucci, Pietro, Paduano, Luigi, Verde, C.
Format: Article in Journal/Newspaper
Language:English
Published: 2011
Subjects:
Online Access:http://hdl.handle.net/11588/389536
https://doi.org/10.1002/iub.450
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spelling ftunivnapoliiris:oai:www.iris.unina.it:11588/389536 2024-09-09T19:20:22+00:00 Polymerization of hemoglobins in Arctic fish: Lycodes reticulatus and Gadus morhua. Riccio A Giordano D Flagiello A Tedesco R Bruno S di Prisco G Verde C. MANGIAPIA, GAETANO VERGARA, ALESSANDRO MAZZARELLA, LELIO PUCCI, PIETRO PADUANO, LUIGI Riccio, A Mangiapia, Gaetano Giordano, D Flagiello, A Tedesco, R Bruno, S Vergara, Alessandro Mazzarella, Lelio di Prisco, G Pucci, Pietro Paduano, Luigi Verde, C. 2011 STAMPA http://hdl.handle.net/11588/389536 https://doi.org/10.1002/iub.450 eng eng info:eu-repo/semantics/altIdentifier/pmid/21491556 info:eu-repo/semantics/altIdentifier/wos/WOS:000291433900008 volume:63 issue:5 firstpage:346 lastpage:354 numberofpages:9 journal:IUBMB LIFE http://hdl.handle.net/11588/389536 doi:10.1002/iub.450 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-79958076343 info:eu-repo/semantics/article 2011 ftunivnapoliiris https://doi.org/10.1002/iub.450 2024-06-17T15:19:26Z In vitro, and possibly in vivo, hemoglobin polymerization and red blood cell sickling appear to be widespread in codfish. In this article, we show that the hemoglobins of the two Arctic fish Lycodes reticulatus and Gadus morhua also have the tendency to polymerize, as monitored by dynamic light scattering experiments. The elucidation of the primary structure of the single hemoglobin of the zoarcid L. reticulatus shows the presence of a large number of cysteyl residues in α and β chains. Their role in eliciting the ability to produce polymers was also addressed by MALDI-TOF and TOF-TOF mass spectrometry. The G.morhua globins are also rich in Cys, but unlike in L. reticulatus, polymerization does not seem to be disulfide driven. The widespread occurrence of the polymerization phenomenon displayed by hemoglobins of Arctic fish supports the hypothesis that this feature may bea response to stressful environmental conditions. Article in Journal/Newspaper Arctic Gadus morhua IRIS Università degli Studi di Napoli Federico II Arctic IUBMB Life 63 5 346 354
institution Open Polar
collection IRIS Università degli Studi di Napoli Federico II
op_collection_id ftunivnapoliiris
language English
description In vitro, and possibly in vivo, hemoglobin polymerization and red blood cell sickling appear to be widespread in codfish. In this article, we show that the hemoglobins of the two Arctic fish Lycodes reticulatus and Gadus morhua also have the tendency to polymerize, as monitored by dynamic light scattering experiments. The elucidation of the primary structure of the single hemoglobin of the zoarcid L. reticulatus shows the presence of a large number of cysteyl residues in α and β chains. Their role in eliciting the ability to produce polymers was also addressed by MALDI-TOF and TOF-TOF mass spectrometry. The G.morhua globins are also rich in Cys, but unlike in L. reticulatus, polymerization does not seem to be disulfide driven. The widespread occurrence of the polymerization phenomenon displayed by hemoglobins of Arctic fish supports the hypothesis that this feature may bea response to stressful environmental conditions.
author2 Riccio, A
Mangiapia, Gaetano
Giordano, D
Flagiello, A
Tedesco, R
Bruno, S
Vergara, Alessandro
Mazzarella, Lelio
di Prisco, G
Pucci, Pietro
Paduano, Luigi
Verde, C.
format Article in Journal/Newspaper
author Riccio A
Giordano D
Flagiello A
Tedesco R
Bruno S
di Prisco G
Verde C.
MANGIAPIA, GAETANO
VERGARA, ALESSANDRO
MAZZARELLA, LELIO
PUCCI, PIETRO
PADUANO, LUIGI
spellingShingle Riccio A
Giordano D
Flagiello A
Tedesco R
Bruno S
di Prisco G
Verde C.
MANGIAPIA, GAETANO
VERGARA, ALESSANDRO
MAZZARELLA, LELIO
PUCCI, PIETRO
PADUANO, LUIGI
Polymerization of hemoglobins in Arctic fish: Lycodes reticulatus and Gadus morhua.
author_facet Riccio A
Giordano D
Flagiello A
Tedesco R
Bruno S
di Prisco G
Verde C.
MANGIAPIA, GAETANO
VERGARA, ALESSANDRO
MAZZARELLA, LELIO
PUCCI, PIETRO
PADUANO, LUIGI
author_sort Riccio A
title Polymerization of hemoglobins in Arctic fish: Lycodes reticulatus and Gadus morhua.
title_short Polymerization of hemoglobins in Arctic fish: Lycodes reticulatus and Gadus morhua.
title_full Polymerization of hemoglobins in Arctic fish: Lycodes reticulatus and Gadus morhua.
title_fullStr Polymerization of hemoglobins in Arctic fish: Lycodes reticulatus and Gadus morhua.
title_full_unstemmed Polymerization of hemoglobins in Arctic fish: Lycodes reticulatus and Gadus morhua.
title_sort polymerization of hemoglobins in arctic fish: lycodes reticulatus and gadus morhua.
publishDate 2011
url http://hdl.handle.net/11588/389536
https://doi.org/10.1002/iub.450
geographic Arctic
geographic_facet Arctic
genre Arctic
Gadus morhua
genre_facet Arctic
Gadus morhua
op_relation info:eu-repo/semantics/altIdentifier/pmid/21491556
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volume:63
issue:5
firstpage:346
lastpage:354
numberofpages:9
journal:IUBMB LIFE
http://hdl.handle.net/11588/389536
doi:10.1002/iub.450
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-79958076343
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