Investigation of the polar steroids from an Antarctic starfish of the family Echinasteridae: isolation of twenty seven polyhydroxysteroids and steroidal oligoglycosides, structures and biological activities

• Main Authors: M. Iorizzi, L. Minale, V. Le Bert, C. Roussakis, DE MARINO, SIMONA, ZOLLO, FRANCO
• Other Authors: M., Iorizzi, DE MARINO, Simona, L., Minale, Zollo, Franco, V., Le Bert, C., Roussakis
• Format: Article in Journal/Newspaper
• Language: English
• Published: 1996
• Subjects: Glycosides of polyhydroxysteroid; Polyhyoxysteroid; human non-small-cell lung carcinoma cells; Antarctic; The Antarctic; Antarc*
• Online Access: http://hdl.handle.net/11588/374135; https://doi.org/10.1016/0040-4020(96)00618; http://www.sciencedirect.com/science/article/pii/0040402096006187

An investigation of the extracts from a starfish collected in the Antarctic Sea, Echinasteridae family, has led to the isolation of thirteen glycosides of polyhydroxysteroids (1-13), fourteen polyhydroxysteroids (14-27), which are the subject of this report, and seven asterosaponins (penta-and hexa-saccharides), described in a previous paper. A selection of fifteen compounds were tested against human non-small-cell lung carcinoma cells and found to be moderately cytotoxic.