Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar
International audience OBJECTIVES:In Madagascar, plague (Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die shortly after infection inducing migration of the fleas. However we previously reported that black rats from...
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2018
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Online Access: | https://hal-riip.archives-ouvertes.fr/pasteur-01968317 https://hal-riip.archives-ouvertes.fr/pasteur-01968317/document https://hal-riip.archives-ouvertes.fr/pasteur-01968317/file/Exposure%20to%20Yersinia%20pestis%20increases%20resistance%20to%20plague%20in%20black%20rats_Andrianaivoarimanana%20et%20al_2018.pdf https://doi.org/10.1186/s13104-018-3984-3 |
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ftunivnantes:oai:HAL:pasteur-01968317v1 2023-05-15T18:05:03+02:00 Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar Andrianaivoarimanana, Voahangy Rajerison, Minoarisoa Jambou, Ronan Unité Peste - Plague Unit Antananarivo, Madagascar Institut Pasteur de Madagascar Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP) Unité d'immunologie des maladies infectieuses Antananarivo, Madagascar (IPM) Département Parasites et Insectes vecteurs - Department of Parasites and Insect Vectors Institut Pasteur Paris (IP) This work was funded by an internal grant from the Institut Pasteur de Madagascar. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. 2018-12-14 https://hal-riip.archives-ouvertes.fr/pasteur-01968317 https://hal-riip.archives-ouvertes.fr/pasteur-01968317/document https://hal-riip.archives-ouvertes.fr/pasteur-01968317/file/Exposure%20to%20Yersinia%20pestis%20increases%20resistance%20to%20plague%20in%20black%20rats_Andrianaivoarimanana%20et%20al_2018.pdf https://doi.org/10.1186/s13104-018-3984-3 en eng HAL CCSD BioMed Central info:eu-repo/semantics/altIdentifier/doi/10.1186/s13104-018-3984-3 info:eu-repo/semantics/altIdentifier/pmid/30551741 pasteur-01968317 https://hal-riip.archives-ouvertes.fr/pasteur-01968317 https://hal-riip.archives-ouvertes.fr/pasteur-01968317/document https://hal-riip.archives-ouvertes.fr/pasteur-01968317/file/Exposure%20to%20Yersinia%20pestis%20increases%20resistance%20to%20plague%20in%20black%20rats_Andrianaivoarimanana%20et%20al_2018.pdf doi:10.1186/s13104-018-3984-3 PUBMED: 30551741 PUBMEDCENTRAL: PMC6295079 http://creativecommons.org/licenses/by/ info:eu-repo/semantics/OpenAccess ISSN: 1756-0500 BMC Research Notes https://hal-riip.archives-ouvertes.fr/pasteur-01968317 BMC Research Notes, 2018, 11 (1), pp.898. ⟨10.1186/s13104-018-3984-3⟩ Plague Rattus rattus F1 antigen Madagascar Outbreak [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases info:eu-repo/semantics/article Journal articles 2018 ftunivnantes https://doi.org/10.1186/s13104-018-3984-3 2023-02-22T08:33:33Z International audience OBJECTIVES:In Madagascar, plague (Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die shortly after infection inducing migration of the fleas. However we previously reported that black rats from endemic areas can survive the infection whereas those from non-endemic areas remained susceptible. We investigate the hypothesis that lineages of rats can acquire resistance to plague and that previous contacts with the bacteria will affect their survival, allowing maintenance of infected fleas. For this purpose, laboratory-born rats were obtained from wild black rats originating either from plague-endemic or plague-free zones, and were challenged with Y. pestis. Survival rate and antibody immune responses were analyzed.RESULTS:Inoculation of low doses of Y. pestis greatly increase survival of rats to subsequent challenge with a lethal dose. During challenge, cytokine profiles support activation of specific immune response associated with the bacteria control. In addition, F1 rats from endemic areas exhibited higher survival rates than those from non-endemic ones, suggesting a selection of a resistant lineage. In Madagascar, these results support the role of black rat as long term reservoir of infected fleas supporting maintenance of plague transmission. Article in Journal/Newspaper Rattus rattus Université de Nantes: HAL-UNIV-NANTES BMC Research Notes 11 1 |
institution |
Open Polar |
collection |
Université de Nantes: HAL-UNIV-NANTES |
op_collection_id |
ftunivnantes |
language |
English |
topic |
Plague Rattus rattus F1 antigen Madagascar Outbreak [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases |
spellingShingle |
Plague Rattus rattus F1 antigen Madagascar Outbreak [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Andrianaivoarimanana, Voahangy Rajerison, Minoarisoa Jambou, Ronan Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
topic_facet |
Plague Rattus rattus F1 antigen Madagascar Outbreak [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases |
description |
International audience OBJECTIVES:In Madagascar, plague (Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die shortly after infection inducing migration of the fleas. However we previously reported that black rats from endemic areas can survive the infection whereas those from non-endemic areas remained susceptible. We investigate the hypothesis that lineages of rats can acquire resistance to plague and that previous contacts with the bacteria will affect their survival, allowing maintenance of infected fleas. For this purpose, laboratory-born rats were obtained from wild black rats originating either from plague-endemic or plague-free zones, and were challenged with Y. pestis. Survival rate and antibody immune responses were analyzed.RESULTS:Inoculation of low doses of Y. pestis greatly increase survival of rats to subsequent challenge with a lethal dose. During challenge, cytokine profiles support activation of specific immune response associated with the bacteria control. In addition, F1 rats from endemic areas exhibited higher survival rates than those from non-endemic ones, suggesting a selection of a resistant lineage. In Madagascar, these results support the role of black rat as long term reservoir of infected fleas supporting maintenance of plague transmission. |
author2 |
Unité Peste - Plague Unit Antananarivo, Madagascar Institut Pasteur de Madagascar Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP) Unité d'immunologie des maladies infectieuses Antananarivo, Madagascar (IPM) Département Parasites et Insectes vecteurs - Department of Parasites and Insect Vectors Institut Pasteur Paris (IP) This work was funded by an internal grant from the Institut Pasteur de Madagascar. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. |
format |
Article in Journal/Newspaper |
author |
Andrianaivoarimanana, Voahangy Rajerison, Minoarisoa Jambou, Ronan |
author_facet |
Andrianaivoarimanana, Voahangy Rajerison, Minoarisoa Jambou, Ronan |
author_sort |
Andrianaivoarimanana, Voahangy |
title |
Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
title_short |
Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
title_full |
Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
title_fullStr |
Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
title_full_unstemmed |
Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
title_sort |
exposure to yersinia pestis increases resistance to plague in black rats and modulates transmission in madagascar |
publisher |
HAL CCSD |
publishDate |
2018 |
url |
https://hal-riip.archives-ouvertes.fr/pasteur-01968317 https://hal-riip.archives-ouvertes.fr/pasteur-01968317/document https://hal-riip.archives-ouvertes.fr/pasteur-01968317/file/Exposure%20to%20Yersinia%20pestis%20increases%20resistance%20to%20plague%20in%20black%20rats_Andrianaivoarimanana%20et%20al_2018.pdf https://doi.org/10.1186/s13104-018-3984-3 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
ISSN: 1756-0500 BMC Research Notes https://hal-riip.archives-ouvertes.fr/pasteur-01968317 BMC Research Notes, 2018, 11 (1), pp.898. ⟨10.1186/s13104-018-3984-3⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1186/s13104-018-3984-3 info:eu-repo/semantics/altIdentifier/pmid/30551741 pasteur-01968317 https://hal-riip.archives-ouvertes.fr/pasteur-01968317 https://hal-riip.archives-ouvertes.fr/pasteur-01968317/document https://hal-riip.archives-ouvertes.fr/pasteur-01968317/file/Exposure%20to%20Yersinia%20pestis%20increases%20resistance%20to%20plague%20in%20black%20rats_Andrianaivoarimanana%20et%20al_2018.pdf doi:10.1186/s13104-018-3984-3 PUBMED: 30551741 PUBMEDCENTRAL: PMC6295079 |
op_rights |
http://creativecommons.org/licenses/by/ info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1186/s13104-018-3984-3 |
container_title |
BMC Research Notes |
container_volume |
11 |
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1 |
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1766176469814345728 |