Vitamin d in the general population of young adults with autism in the faroe islands.

• Published in: Journal of Autism and Developmental Disorders
• Main Authors: Kočovská, Eva, Andorsdóttir, Guðrið, Weihe, Pál, Halling, Jónrit, Fernell, Elisabeth, Stóra, Tormóður, Biskupstø, Rannvá, Gillberg, I Carina, Shea, Robyn, Billstedt, Eva, Bourgeron, Thomas, Minnis, Helen, Gillberg, Christopher
• Other Authors: University of Glasgow, University of Gothenburg (GU), Ministry of Health and The Interior Faroe Islands, The Faroese Hospital System (Landssjúkrahúsið) (LS), Birmingham City Hospital, Gènes, Synapses et Cognition (CNRS - UMR3571 ), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur Paris (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), The Swedish Science Council, ALF, Niklas Öberg Life Watch Award, and Ragnar and Alexandra Söderberg for funding., We thank Gunnrið Jóanesarson for preparation of the blood samples for the analysis; the staff from the Vitamins Laboratory at City Hospital, Birmingham for analysing the vitamin D concentrations; Dr. David Young, Dr. Alex McConnachie, Dr. Sarah Barry, and Miss Nicola Greenlaw for their assistance with the statistical analysis
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2014
• Subjects: Autism; ASD; Vitamin D; Calcitriol; Total population; Faroe Islands; MESH: Adolescent; MESH: Autistic Disorder; MESH: Male; MESH: Population Surveillance; MESH: Risk Factors; MESH: Vitamin D; MESH: Vitamin D Deficiency; MESH: Young Adult; MESH: Cohort Studies; MESH: Cross-Sectional Studies; MESH: Denmark; MESH: Female; MESH: Humans; [SCCO]Cognitive science; [SDV]Life Sciences [q-bio]; [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
• Online Access: https://hal-pasteur.archives-ouvertes.fr/pasteur-01579765; https://hal-pasteur.archives-ouvertes.fr/pasteur-01579765/document; https://hal-pasteur.archives-ouvertes.fr/pasteur-01579765/file/s10803-014-2155-1.pdf; https://doi.org/10.1007/s10803-014-2155-1

International audience Vitamin D deficiency has been proposed as a possible risk factor for developing autism spectrum disorder (ASD). 25-Hydroxyvitamin D3 (25(OH)D3) levels were examined in a cross-sectional population-based study in the Faroe Islands. The case group consisting of a total population cohort of 40 individuals with ASD (aged 15-24 years) had significantly lower 25(OH)D3 than their 62 typically-developing siblings and their 77 parents, and also significantly lower than 40 healthy age and gender matched comparisons. There was a trend for males having lower 25(OH)D3 than females. Effects of age, month/season of birth, IQ, various subcategories of ASD and Autism Diagnostic Observation Schedule score were also investigated, however, no association was found. The very low 25(OH)D3 in the ASD group suggests some underlying pathogenic mechanism.