Multiple Kisspeptin Receptors in Early Osteichthyans Provide New Insights into the Evolution of This Receptor Family
International audience Deorphanization of GPR54 receptor a decade ago led to the characterization of the kisspeptin receptor (Kissr) in mammalsand the discovery of its major role in the brain control of reproduction. While a single gene encodes for Kissr in eutherianmammals including human, other ve...
Published in: | PLoS ONE |
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Main Authors: | , , , , , , , , , , |
Other Authors: | , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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HAL CCSD
2012
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Subjects: | |
Online Access: | https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073 https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073/document https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073/file/pone.0048931.pdf https://doi.org/10.1371/journal.pone.0048931 |
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ftunivnantes:oai:HAL:mnhn-02861073v1 |
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Open Polar |
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Université de Nantes: HAL-UNIV-NANTES |
op_collection_id |
ftunivnantes |
language |
English |
topic |
[SDV]Life Sciences [q-bio] |
spellingShingle |
[SDV]Life Sciences [q-bio] Pasquier, Jérémy Lafont, Anne-Gaëlle Jeng, Shan-Ru Morini, Marina Dirks, Ron van den Thillart, Guido Tomkiewicz, Jonna Tostivint, Hervé Chang, Ching-Fong Rousseau, Karine Dufour, Sylvie Multiple Kisspeptin Receptors in Early Osteichthyans Provide New Insights into the Evolution of This Receptor Family |
topic_facet |
[SDV]Life Sciences [q-bio] |
description |
International audience Deorphanization of GPR54 receptor a decade ago led to the characterization of the kisspeptin receptor (Kissr) in mammalsand the discovery of its major role in the brain control of reproduction. While a single gene encodes for Kissr in eutherianmammals including human, other vertebrates present a variable number of Kissr genes, from none in birds, one or two inteleosts, to three in an amphibian, xenopus. In order to get more insight into the evolution of Kissr gene family, weinvestigated the presence of Kissr in osteichthyans of key-phylogenetical positions: the coelacanth, a representative of earlysarcopterygians, the spotted gar, a non-teleost actinopterygian, and the European eel, a member of an early group ofteleosts (elopomorphs). We report the occurrence of three Kissr for the first time in a teleost, the eel. As measured byquantitative RT-PCR, the three eel Kissr were differentially expressed in the brain-pituitary-gonadal axis, and differentiallyregulated in experimentally matured eels, as compared to prepubertal controls. Subfunctionalisation, as shown by thesedifferences in tissue distribution and regulation, may have represented significant evolutionary constraints for theconservation of multiple Kissr paralogs in this species. Furthermore, we identified four Kissr in both coelacanth and spottedgar genomes, providing the first evidence for the presence of four Kissr in vertebrates. Phylogenetic and syntenic analysessupported the existence of four Kissr paralogs in osteichthyans and allowed to propose a clarified nomenclature of Kissr(Kissr-1 to -4) based on these paralogs. Syntenic analysis suggested that the four Kissr paralogs arose through the tworounds of whole genome duplication (1R and 2R) in early vertebrates, followed by multiple gene loss events in theactinopterygian and sarcopterygian lineages. Due to gene loss there was no impact of the teleost-specific whole genomeduplication (3R) on the number of Kissr paralogs in current teleosts. |
author2 |
Biologie des Organismes et Ecosystèmes Aquatiques (BOREA) Université de Caen Normandie (UNICAEN) Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA) Institut de recherche en santé, environnement et travail (Irset) Université d'Angers (UA)-Université de Rennes 1 (UR1) Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) Universitat Politècnica de València (UPV) Leiden University DTU Aqua, National Institute of Aquatic Resources Danmarks Tekniske Universitet = Technical University of Denmark (DTU) Neuroendocrinologie cellulaire et moléculaire Université de Rouen Normandie (UNIROUEN) Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM) National Taiwan Ocean University (NTOU) |
format |
Article in Journal/Newspaper |
author |
Pasquier, Jérémy Lafont, Anne-Gaëlle Jeng, Shan-Ru Morini, Marina Dirks, Ron van den Thillart, Guido Tomkiewicz, Jonna Tostivint, Hervé Chang, Ching-Fong Rousseau, Karine Dufour, Sylvie |
author_facet |
Pasquier, Jérémy Lafont, Anne-Gaëlle Jeng, Shan-Ru Morini, Marina Dirks, Ron van den Thillart, Guido Tomkiewicz, Jonna Tostivint, Hervé Chang, Ching-Fong Rousseau, Karine Dufour, Sylvie |
author_sort |
Pasquier, Jérémy |
title |
Multiple Kisspeptin Receptors in Early Osteichthyans Provide New Insights into the Evolution of This Receptor Family |
title_short |
Multiple Kisspeptin Receptors in Early Osteichthyans Provide New Insights into the Evolution of This Receptor Family |
title_full |
Multiple Kisspeptin Receptors in Early Osteichthyans Provide New Insights into the Evolution of This Receptor Family |
title_fullStr |
Multiple Kisspeptin Receptors in Early Osteichthyans Provide New Insights into the Evolution of This Receptor Family |
title_full_unstemmed |
Multiple Kisspeptin Receptors in Early Osteichthyans Provide New Insights into the Evolution of This Receptor Family |
title_sort |
multiple kisspeptin receptors in early osteichthyans provide new insights into the evolution of this receptor family |
publisher |
HAL CCSD |
publishDate |
2012 |
url |
https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073 https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073/document https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073/file/pone.0048931.pdf https://doi.org/10.1371/journal.pone.0048931 |
long_lat |
ENVELOPE(162.014,162.014,57.140,57.140) |
geographic |
Gar’ |
geographic_facet |
Gar’ |
genre |
European eel |
genre_facet |
European eel |
op_source |
ISSN: 1932-6203 EISSN: 1932-6203 PLoS ONE https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073 PLoS ONE, Public Library of Science, 2012, 7 (11), pp.e48931. ⟨10.1371/journal.pone.0048931⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0048931 mnhn-02861073 https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073 https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073/document https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073/file/pone.0048931.pdf doi:10.1371/journal.pone.0048931 |
op_rights |
http://creativecommons.org/licenses/by/ info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0048931 |
container_title |
PLoS ONE |
container_volume |
7 |
container_issue |
11 |
container_start_page |
e48931 |
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spelling |
ftunivnantes:oai:HAL:mnhn-02861073v1 2023-05-15T16:08:42+02:00 Multiple Kisspeptin Receptors in Early Osteichthyans Provide New Insights into the Evolution of This Receptor Family Pasquier, Jérémy Lafont, Anne-Gaëlle Jeng, Shan-Ru Morini, Marina Dirks, Ron van den Thillart, Guido Tomkiewicz, Jonna Tostivint, Hervé Chang, Ching-Fong Rousseau, Karine Dufour, Sylvie Biologie des Organismes et Ecosystèmes Aquatiques (BOREA) Université de Caen Normandie (UNICAEN) Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA) Institut de recherche en santé, environnement et travail (Irset) Université d'Angers (UA)-Université de Rennes 1 (UR1) Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) Universitat Politècnica de València (UPV) Leiden University DTU Aqua, National Institute of Aquatic Resources Danmarks Tekniske Universitet = Technical University of Denmark (DTU) Neuroendocrinologie cellulaire et moléculaire Université de Rouen Normandie (UNIROUEN) Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM) National Taiwan Ocean University (NTOU) 2012-11-20 https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073 https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073/document https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073/file/pone.0048931.pdf https://doi.org/10.1371/journal.pone.0048931 en eng HAL CCSD Public Library of Science info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0048931 mnhn-02861073 https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073 https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073/document https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073/file/pone.0048931.pdf doi:10.1371/journal.pone.0048931 http://creativecommons.org/licenses/by/ info:eu-repo/semantics/OpenAccess ISSN: 1932-6203 EISSN: 1932-6203 PLoS ONE https://hal-mnhn.archives-ouvertes.fr/mnhn-02861073 PLoS ONE, Public Library of Science, 2012, 7 (11), pp.e48931. ⟨10.1371/journal.pone.0048931⟩ [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2012 ftunivnantes https://doi.org/10.1371/journal.pone.0048931 2022-08-10T01:50:53Z International audience Deorphanization of GPR54 receptor a decade ago led to the characterization of the kisspeptin receptor (Kissr) in mammalsand the discovery of its major role in the brain control of reproduction. While a single gene encodes for Kissr in eutherianmammals including human, other vertebrates present a variable number of Kissr genes, from none in birds, one or two inteleosts, to three in an amphibian, xenopus. In order to get more insight into the evolution of Kissr gene family, weinvestigated the presence of Kissr in osteichthyans of key-phylogenetical positions: the coelacanth, a representative of earlysarcopterygians, the spotted gar, a non-teleost actinopterygian, and the European eel, a member of an early group ofteleosts (elopomorphs). We report the occurrence of three Kissr for the first time in a teleost, the eel. As measured byquantitative RT-PCR, the three eel Kissr were differentially expressed in the brain-pituitary-gonadal axis, and differentiallyregulated in experimentally matured eels, as compared to prepubertal controls. Subfunctionalisation, as shown by thesedifferences in tissue distribution and regulation, may have represented significant evolutionary constraints for theconservation of multiple Kissr paralogs in this species. Furthermore, we identified four Kissr in both coelacanth and spottedgar genomes, providing the first evidence for the presence of four Kissr in vertebrates. Phylogenetic and syntenic analysessupported the existence of four Kissr paralogs in osteichthyans and allowed to propose a clarified nomenclature of Kissr(Kissr-1 to -4) based on these paralogs. Syntenic analysis suggested that the four Kissr paralogs arose through the tworounds of whole genome duplication (1R and 2R) in early vertebrates, followed by multiple gene loss events in theactinopterygian and sarcopterygian lineages. Due to gene loss there was no impact of the teleost-specific whole genomeduplication (3R) on the number of Kissr paralogs in current teleosts. Article in Journal/Newspaper European eel Université de Nantes: HAL-UNIV-NANTES Gar’ ENVELOPE(162.014,162.014,57.140,57.140) PLoS ONE 7 11 e48931 |