Experimental host-induced selection in Schistosoma mansoni strains from Guadeloupe and comparison with natural observations

• Published in: Heredity
• Main Authors: Bremond, P., Pasteur, Nicole, Combes, Claude, Renaud, François, Theron, André
• Other Authors: Parasitologie fonctionnelle et évolutive 2003-2006 (PFE), Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement IRD : UR226-Centre National de la Recherche Scientifique (CNRS), Génétique et évolution des maladies infectieuses (GEMI), Université Montpellier 1 (UM1)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD France-Sud )
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 1993
• Subjects: HOST SELECTION; PARASITE; RANDOM DRIFT; RATTUS RATTUS; SCHISTOSOMA MANSONI; ENZYME POLYMORPHISM; WEST-INDIES; POPULATIONS; RODHAINI; ENZYMATIC POLYMORPHISM; [SDV.GEN]Life Sciences [q-bio]/Genetics; Rattus rattus
• Online Access: https://hal.science/halsde-00201339; https://doi.org/10.1038/hdy.1993.5

International audience Allelic frequency variation at the malate dehydrogenase (E.C.1.1.1.37) polymorphic locus (Mdh-1) was analysed during several successive generations in four strains of Schistosoma mansoni from Guadeloupe, maintained experimentally on mice. A rapid evolution of the frequency of the Mdh-1a allele is interpreted as being the result of an interaction between experimental drift and selection induced by the murine laboratory host. These experimental results are compared to the genetic structures observed among the corresponding natural populations of S. mansoni in Guadeloupe (West Indies). They strengthen the hypothesis of a natural host-induced selection by the murine host (Rattus rattus), which, in Guadeloupe, plays the role of host reservoir for this human schistosome.