Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France)
International audience The presence of contaminants of emerging concern in the aquatic environment directly impacts water-living organisms and can alter their living functions. These compounds are often metabolized and excreted, but they can also be accumulated and spread through the food chain. The...
Published in: | Environmental Pollution |
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Main Authors: | , , , , , , |
Other Authors: | , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
HAL CCSD
2022
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Subjects: | |
Online Access: | https://hal.inrae.fr/hal-03806233 https://hal.inrae.fr/hal-03806233/document https://hal.inrae.fr/hal-03806233/file/2022_AlvarezMora_EnvironmentalPollution.pdf https://doi.org/10.1016/j.envpol.2022.120016 |
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ftunivnantes:oai:HAL:hal-03806233v1 |
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institution |
Open Polar |
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Université de Nantes: HAL-UNIV-NANTES |
op_collection_id |
ftunivnantes |
language |
English |
topic |
Glass eel Contaminants of emerging concern Bioconcentration Biotransformation Suspect screening HPLC-HRMS [SDE.BE]Environmental Sciences/Biodiversity and Ecology [SDV.TOX]Life Sciences [q-bio]/Toxicology |
spellingShingle |
Glass eel Contaminants of emerging concern Bioconcentration Biotransformation Suspect screening HPLC-HRMS [SDE.BE]Environmental Sciences/Biodiversity and Ecology [SDV.TOX]Life Sciences [q-bio]/Toxicology Alvarez-Mora, Iker Bolliet, Valérie Lopez-Herguedas, Naroa Castro, Lyen Anakabe, Eneritz Monperrus, Mathilde Etxebarria, Nestor Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France) |
topic_facet |
Glass eel Contaminants of emerging concern Bioconcentration Biotransformation Suspect screening HPLC-HRMS [SDE.BE]Environmental Sciences/Biodiversity and Ecology [SDV.TOX]Life Sciences [q-bio]/Toxicology |
description |
International audience The presence of contaminants of emerging concern in the aquatic environment directly impacts water-living organisms and can alter their living functions. These compounds are often metabolized and excreted, but they can also be accumulated and spread through the food chain. The metabolized contaminants can also lead to the formation of new compounds with unknown toxicity and bioaccumulation potential. In this work, we have studied the occurrence, bioconcentration, and biotransformation of CECs in glass eels (Anguilla anguilla) using UHPLC-HRMS. To select the target CECs, we first carried out an environmental risk assessment of the WWTP effluent that releases directly into the Adour estuary (Bayonne, Basque Country, France). The risk quotients of every detected contaminant were calculated and three ecotoxicologically relevant contaminants were chosen to perform the exposure experiment: propranolol, diazepam, and irbesartan. An experiment of 14 days consisting of 7 days of exposure and 7 days of depuration was carried out to measure the bioconcentration of the chosen compounds. The quantitative results of the concentrations in glass eel showed that diazepam and irbesartan reached BCF ≈10 on day 7, but both compounds were eliminated after 7 days of depuration. On the other hand, propranolol's concentration remains constant all along with the experiment, and its presence can be detected even in the non-exposed control group, which might suggest environmental contamination. Two additional suspect screening strategies were used to identify metabolization products of the target compounds and other xenobiotics already present in wild glass eels. Only one metabolite was identified, nordiazepam, a well-known diazepam metabolite, probably due to the low metabolic rate of glass eels at this stage. The xenobiotic screening confirmed the presence of more xenobiotics in wild glass eels, prominent among them, the pharmaceuticals exemestane, primidone, iloprost, and norethandrolone. ☆ This paper has been ... |
author2 |
Department of Analytical Chemistry, University of the Basque Country UPV/ EHU, P.O. Box 644, E-48080, Bilbao, Spain University of the Basque Country (University of the Basque Country) Plentzia Marine Station, University of the Basque Country University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU) Ecologie Comportementale et Biologie des Populations de Poissons (ECOBIOP) Université de Pau et des Pays de l'Adour (UPPA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) Department of Organic and Inorganic Chemistry, University of the Basque Country Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM) Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) Agencia Estatal de Investigaci ́on (AEI) of Spain European Regional Development Fund through project CTM2017–84763-C3–1-R Basque Government through the financial support as a consolidated group of the Basque Research System (IT1213–19) University of the Basque Country Université de Pau et des Pays de l'Adour |
format |
Article in Journal/Newspaper |
author |
Alvarez-Mora, Iker Bolliet, Valérie Lopez-Herguedas, Naroa Castro, Lyen Anakabe, Eneritz Monperrus, Mathilde Etxebarria, Nestor |
author_facet |
Alvarez-Mora, Iker Bolliet, Valérie Lopez-Herguedas, Naroa Castro, Lyen Anakabe, Eneritz Monperrus, Mathilde Etxebarria, Nestor |
author_sort |
Alvarez-Mora, Iker |
title |
Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France) |
title_short |
Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France) |
title_full |
Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France) |
title_fullStr |
Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France) |
title_full_unstemmed |
Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France) |
title_sort |
prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (anguilla anguilla) from the adour estuary (basque country, france) |
publisher |
HAL CCSD |
publishDate |
2022 |
url |
https://hal.inrae.fr/hal-03806233 https://hal.inrae.fr/hal-03806233/document https://hal.inrae.fr/hal-03806233/file/2022_AlvarezMora_EnvironmentalPollution.pdf https://doi.org/10.1016/j.envpol.2022.120016 |
long_lat |
ENVELOPE(-70.983,-70.983,-68.933,-68.933) |
geographic |
Bayonne |
geographic_facet |
Bayonne |
genre |
Anguilla anguilla |
genre_facet |
Anguilla anguilla |
op_source |
ISSN: 0269-7491 EISSN: 1873-6424 Environmental Pollution https://hal.inrae.fr/hal-03806233 Environmental Pollution, 2022, 311, ⟨10.1016/j.envpol.2022.120016⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.envpol.2022.120016 hal-03806233 https://hal.inrae.fr/hal-03806233 https://hal.inrae.fr/hal-03806233/document https://hal.inrae.fr/hal-03806233/file/2022_AlvarezMora_EnvironmentalPollution.pdf doi:10.1016/j.envpol.2022.120016 WOS: 000860183600002 |
op_rights |
http://creativecommons.org/licenses/by-nc/ info:eu-repo/semantics/OpenAccess |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1016/j.envpol.2022.120016 |
container_title |
Environmental Pollution |
container_volume |
311 |
container_start_page |
120016 |
_version_ |
1766399365401804800 |
spelling |
ftunivnantes:oai:HAL:hal-03806233v1 2023-05-15T13:27:36+02:00 Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France) Alvarez-Mora, Iker Bolliet, Valérie Lopez-Herguedas, Naroa Castro, Lyen Anakabe, Eneritz Monperrus, Mathilde Etxebarria, Nestor Department of Analytical Chemistry, University of the Basque Country UPV/ EHU, P.O. Box 644, E-48080, Bilbao, Spain University of the Basque Country (University of the Basque Country) Plentzia Marine Station, University of the Basque Country University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU) Ecologie Comportementale et Biologie des Populations de Poissons (ECOBIOP) Université de Pau et des Pays de l'Adour (UPPA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) Department of Organic and Inorganic Chemistry, University of the Basque Country Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM) Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) Agencia Estatal de Investigaci ́on (AEI) of Spain European Regional Development Fund through project CTM2017–84763-C3–1-R Basque Government through the financial support as a consolidated group of the Basque Research System (IT1213–19) University of the Basque Country Université de Pau et des Pays de l'Adour 2022 https://hal.inrae.fr/hal-03806233 https://hal.inrae.fr/hal-03806233/document https://hal.inrae.fr/hal-03806233/file/2022_AlvarezMora_EnvironmentalPollution.pdf https://doi.org/10.1016/j.envpol.2022.120016 en eng HAL CCSD Elsevier info:eu-repo/semantics/altIdentifier/doi/10.1016/j.envpol.2022.120016 hal-03806233 https://hal.inrae.fr/hal-03806233 https://hal.inrae.fr/hal-03806233/document https://hal.inrae.fr/hal-03806233/file/2022_AlvarezMora_EnvironmentalPollution.pdf doi:10.1016/j.envpol.2022.120016 WOS: 000860183600002 http://creativecommons.org/licenses/by-nc/ info:eu-repo/semantics/OpenAccess CC-BY-NC ISSN: 0269-7491 EISSN: 1873-6424 Environmental Pollution https://hal.inrae.fr/hal-03806233 Environmental Pollution, 2022, 311, ⟨10.1016/j.envpol.2022.120016⟩ Glass eel Contaminants of emerging concern Bioconcentration Biotransformation Suspect screening HPLC-HRMS [SDE.BE]Environmental Sciences/Biodiversity and Ecology [SDV.TOX]Life Sciences [q-bio]/Toxicology info:eu-repo/semantics/article Journal articles 2022 ftunivnantes https://doi.org/10.1016/j.envpol.2022.120016 2023-02-22T01:30:21Z International audience The presence of contaminants of emerging concern in the aquatic environment directly impacts water-living organisms and can alter their living functions. These compounds are often metabolized and excreted, but they can also be accumulated and spread through the food chain. The metabolized contaminants can also lead to the formation of new compounds with unknown toxicity and bioaccumulation potential. In this work, we have studied the occurrence, bioconcentration, and biotransformation of CECs in glass eels (Anguilla anguilla) using UHPLC-HRMS. To select the target CECs, we first carried out an environmental risk assessment of the WWTP effluent that releases directly into the Adour estuary (Bayonne, Basque Country, France). The risk quotients of every detected contaminant were calculated and three ecotoxicologically relevant contaminants were chosen to perform the exposure experiment: propranolol, diazepam, and irbesartan. An experiment of 14 days consisting of 7 days of exposure and 7 days of depuration was carried out to measure the bioconcentration of the chosen compounds. The quantitative results of the concentrations in glass eel showed that diazepam and irbesartan reached BCF ≈10 on day 7, but both compounds were eliminated after 7 days of depuration. On the other hand, propranolol's concentration remains constant all along with the experiment, and its presence can be detected even in the non-exposed control group, which might suggest environmental contamination. Two additional suspect screening strategies were used to identify metabolization products of the target compounds and other xenobiotics already present in wild glass eels. Only one metabolite was identified, nordiazepam, a well-known diazepam metabolite, probably due to the low metabolic rate of glass eels at this stage. The xenobiotic screening confirmed the presence of more xenobiotics in wild glass eels, prominent among them, the pharmaceuticals exemestane, primidone, iloprost, and norethandrolone. ☆ This paper has been ... Article in Journal/Newspaper Anguilla anguilla Université de Nantes: HAL-UNIV-NANTES Bayonne ENVELOPE(-70.983,-70.983,-68.933,-68.933) Environmental Pollution 311 120016 |