Toxicity assessment of peptaibols and contaminated sediments on Crassostrea gigas embryos

• Published in: Aquatic Toxicology
• Main Authors: Poirier, Laurence, Quiniou, Françoise, Ruiz, Nicolas, Montagu, Monique, Amiard, Jean-Claude, Pouchus, Yves François
• Other Authors: Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN), Unité Biogéochimie et Ecotoxicologie (BE), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2007
• Subjects: Marine fungi; Mycotoxins; Bivalve bioassay; Embryotoxicity; Risk assessment; [SDE]Environmental Sciences; [SDV]Life Sciences [q-bio]; Crassostrea gigas
• Online Access: https://nantes-universite.hal.science/hal-03596297; https://doi.org/10.1016/j.aquatox.2007.04.009

International audience Peptaibols are known membrane-modifying peptides that were recently detected in marine sediments and mussels collected from a shellfish farming area (Fier d'Ars, Atlantic coast, France). In this investigation, embryotoxicity bioassays with oysters (Crassostrea gigas) were performed to assess acute toxicity of alamethicin and different groups of peptaibols produced by a Trichoderma longibrachiatum strain isolated from marine environment. C. gigas embryos appeared very sensitive to all the metabolites examined with higher toxic effects for long-sequence peptides (EC 50 ranging from 10 to 64 nM). D-shaped larvae with mantle abnormality were particularly noticed when peptaibol concentrations increased. Disturbances of embryogenesis were also observed following exposure to organic and aqueous extract of sediments from Fier d'Ars (EC 50 = 42.4 and 6.6 g L −1 dry weight, respectively). Although peptaibol concentrations measured in these sediments could explain only a part of the toxic effects observed, this study suggests that these mycotoxins can induce larval abnormalities in a population of exposed animals at environmentally realistic concentrations. Their detection in coastal areas devoted to bivalve culture should be taken into account.