Per‐ and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird
International audience Per‐ and polyfluoroalkyl substances (PFAS) are associated with several disrupted physiological and endocrine parameters. Regarding endocrine mechanisms, laboratory studies suggest that PFAS could disrupt the thyroid hormone system and alter circulating thyroid hormone concentr...
Published in: | Environmental Toxicology and Chemistry |
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Online Access: | https://hal.archives-ouvertes.fr/hal-03138452 https://doi.org/10.1002/etc.4978 |
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ftunivnantes:oai:HAL:hal-03138452v1 2023-05-15T15:00:37+02:00 Per‐ and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird Ask, Amalie Vigdel Jenssen, Bjørn Munro Tartu, Sabrina Angelier, Frédéric Chastel, Olivier Gabrielsen, Geir Wing Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC) La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) 2021 https://hal.archives-ouvertes.fr/hal-03138452 https://doi.org/10.1002/etc.4978 en eng HAL CCSD Wiley info:eu-repo/semantics/altIdentifier/doi/10.1002/etc.4978 hal-03138452 https://hal.archives-ouvertes.fr/hal-03138452 doi:10.1002/etc.4978 ISSN: 0730-7268 EISSN: 1552-8618 Environmental Toxicology and Chemistry https://hal.archives-ouvertes.fr/hal-03138452 Environmental Toxicology and Chemistry, 2021, 40 (3), pp.820-831. ⟨10.1002/etc.4978⟩ Avian toxicity Ecotoxicology Endocrine‐disrupting compounds Per‐ and polyfluoroalkyl substance Thyroid hormones [SDE]Environmental Sciences info:eu-repo/semantics/article Journal articles 2021 ftunivnantes https://doi.org/10.1002/etc.4978 2023-01-03T23:58:53Z International audience Per‐ and polyfluoroalkyl substances (PFAS) are associated with several disrupted physiological and endocrine parameters. Regarding endocrine mechanisms, laboratory studies suggest that PFAS could disrupt the thyroid hormone system and alter circulating thyroid hormone concentrations. Thyroid hormones play a ubiquitous role—controlling thermoregulation, metabolism, and reproduction. However, evidence for disruption of thyroid hormones by PFAS remains scarce in wildlife. The present study investigated the associations between concentrations of PFAS, thyroid hormones, and body condition in an arctic seabird, the black‐legged kittiwake (Rissa tridactyla). We collected blood from kittiwakes sampled in Svalbard, Norway (2013 and 2014). Plasma samples were analyzed for total thyroxine (TT4) and total triiodothyronine (TT3) concentrations; detected PFAS included branched and linear (lin) C8 perfluoroalkyl sulfonates (i.e., perfluoroctane sulfonate [PFOS]) and C9‐C14 perfluoroalkyl carboxylates (PFCAs). The dominant PFAS in the kittiwakes were linPFOS and C11‐ and C13‐PFCAs. Generally, male kittiwakes had higher concentrations of PFAS than females. We observed positive correlations between linPFOS, C10‐PFCA, and TT4 in males, whereas in females C12‐14‐PFCAs were positively correlated to TT3. Interestingly, we observed contrasted correlations between PFAS and body condition; the direction of the relationship was sex‐dependent. Although these results show relationships between PFAS and circulating thyroid hormone concentrations in kittiwakes, the study design does not allow for concluding on causal relationships related to effects of PFAS on the thyroid hormone system. Future experimental research is required to quantify this impact of PFAS on the biology of kittiwakes. The apparently different associations among PFAS and body condition for males and females are puzzling, and more research is required. Environ Toxicol Chem 2021;00:1–12. © 2020 The Authors. Environmental Toxicology and Chemistry ... Article in Journal/Newspaper Arctic Black-legged Kittiwake rissa tridactyla Svalbard Université de Nantes: HAL-UNIV-NANTES Arctic Norway Svalbard Environmental Toxicology and Chemistry 40 3 820 831 |
institution |
Open Polar |
collection |
Université de Nantes: HAL-UNIV-NANTES |
op_collection_id |
ftunivnantes |
language |
English |
topic |
Avian toxicity Ecotoxicology Endocrine‐disrupting compounds Per‐ and polyfluoroalkyl substance Thyroid hormones [SDE]Environmental Sciences |
spellingShingle |
Avian toxicity Ecotoxicology Endocrine‐disrupting compounds Per‐ and polyfluoroalkyl substance Thyroid hormones [SDE]Environmental Sciences Ask, Amalie Vigdel Jenssen, Bjørn Munro Tartu, Sabrina Angelier, Frédéric Chastel, Olivier Gabrielsen, Geir Wing Per‐ and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird |
topic_facet |
Avian toxicity Ecotoxicology Endocrine‐disrupting compounds Per‐ and polyfluoroalkyl substance Thyroid hormones [SDE]Environmental Sciences |
description |
International audience Per‐ and polyfluoroalkyl substances (PFAS) are associated with several disrupted physiological and endocrine parameters. Regarding endocrine mechanisms, laboratory studies suggest that PFAS could disrupt the thyroid hormone system and alter circulating thyroid hormone concentrations. Thyroid hormones play a ubiquitous role—controlling thermoregulation, metabolism, and reproduction. However, evidence for disruption of thyroid hormones by PFAS remains scarce in wildlife. The present study investigated the associations between concentrations of PFAS, thyroid hormones, and body condition in an arctic seabird, the black‐legged kittiwake (Rissa tridactyla). We collected blood from kittiwakes sampled in Svalbard, Norway (2013 and 2014). Plasma samples were analyzed for total thyroxine (TT4) and total triiodothyronine (TT3) concentrations; detected PFAS included branched and linear (lin) C8 perfluoroalkyl sulfonates (i.e., perfluoroctane sulfonate [PFOS]) and C9‐C14 perfluoroalkyl carboxylates (PFCAs). The dominant PFAS in the kittiwakes were linPFOS and C11‐ and C13‐PFCAs. Generally, male kittiwakes had higher concentrations of PFAS than females. We observed positive correlations between linPFOS, C10‐PFCA, and TT4 in males, whereas in females C12‐14‐PFCAs were positively correlated to TT3. Interestingly, we observed contrasted correlations between PFAS and body condition; the direction of the relationship was sex‐dependent. Although these results show relationships between PFAS and circulating thyroid hormone concentrations in kittiwakes, the study design does not allow for concluding on causal relationships related to effects of PFAS on the thyroid hormone system. Future experimental research is required to quantify this impact of PFAS on the biology of kittiwakes. The apparently different associations among PFAS and body condition for males and females are puzzling, and more research is required. Environ Toxicol Chem 2021;00:1–12. © 2020 The Authors. Environmental Toxicology and Chemistry ... |
author2 |
Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC) La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
format |
Article in Journal/Newspaper |
author |
Ask, Amalie Vigdel Jenssen, Bjørn Munro Tartu, Sabrina Angelier, Frédéric Chastel, Olivier Gabrielsen, Geir Wing |
author_facet |
Ask, Amalie Vigdel Jenssen, Bjørn Munro Tartu, Sabrina Angelier, Frédéric Chastel, Olivier Gabrielsen, Geir Wing |
author_sort |
Ask, Amalie Vigdel |
title |
Per‐ and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird |
title_short |
Per‐ and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird |
title_full |
Per‐ and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird |
title_fullStr |
Per‐ and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird |
title_full_unstemmed |
Per‐ and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird |
title_sort |
per‐ and polyfluoroalkyl substances are positively associated with thyroid hormones in an arctic seabird |
publisher |
HAL CCSD |
publishDate |
2021 |
url |
https://hal.archives-ouvertes.fr/hal-03138452 https://doi.org/10.1002/etc.4978 |
geographic |
Arctic Norway Svalbard |
geographic_facet |
Arctic Norway Svalbard |
genre |
Arctic Black-legged Kittiwake rissa tridactyla Svalbard |
genre_facet |
Arctic Black-legged Kittiwake rissa tridactyla Svalbard |
op_source |
ISSN: 0730-7268 EISSN: 1552-8618 Environmental Toxicology and Chemistry https://hal.archives-ouvertes.fr/hal-03138452 Environmental Toxicology and Chemistry, 2021, 40 (3), pp.820-831. ⟨10.1002/etc.4978⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1002/etc.4978 hal-03138452 https://hal.archives-ouvertes.fr/hal-03138452 doi:10.1002/etc.4978 |
op_doi |
https://doi.org/10.1002/etc.4978 |
container_title |
Environmental Toxicology and Chemistry |
container_volume |
40 |
container_issue |
3 |
container_start_page |
820 |
op_container_end_page |
831 |
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1766332698020806656 |