Detection of rat hepatitis E virus in wild Norway rats (Rattus norvegicus) and Black rats (Rattus rattus) from 11 European countries
International audience Rat hepatitis E virus (HEV) is genetically only distantly related to hepeviruses found in other mammalian reservoirs and in humans. It was initially detected in Norway rats (Rattus norvegicus) from Germany, and subsequently in rats from Vietnam, the USA, Indonesia, China, Denm...
Published in: | Veterinary Microbiology |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Other Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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HAL CCSD
2017
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Online Access: | https://hal.archives-ouvertes.fr/hal-01953659 https://doi.org/10.1016/j.vetmic.2017.07.001 |
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ftunivnantes:oai:HAL:hal-01953659v1 |
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Open Polar |
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Université de Nantes: HAL-UNIV-NANTES |
op_collection_id |
ftunivnantes |
language |
English |
topic |
Animal Distribution Male Humans Norway rat Phylogeny Animals Wild Black rat Europe Female Genotype 3 Hepatitis E Hepatitis E virus Hepeviridae Population Density Rats Species Specificity [SDV.IMM]Life Sciences [q-bio]/Immunology [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology |
spellingShingle |
Animal Distribution Male Humans Norway rat Phylogeny Animals Wild Black rat Europe Female Genotype 3 Hepatitis E Hepatitis E virus Hepeviridae Population Density Rats Species Specificity [SDV.IMM]Life Sciences [q-bio]/Immunology [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Ryll, René Bernstein, Samuel Heuser, Elisa Schlegel, Mathias Dremsek, Paul Zumpe, Maxi Wolf, Sandro Pépin, Michel Bajomi, Daniel Müller, Gabi Heiberg, Ann-Charlotte Spahr, Carina Lang, Johannes Groschup, Martin H. Ansorge, Hermann Freise, Jona Guenther, Sebastian Baert, Kristof Ruiz-Fons, Francisco Pikula, Jiri Knap, Nataša Tsakmakidis, Joannis Dovas, Chrysostomos Zanet, Stefania Imholt, Christian Heckel, Gerald Johne, Reimar Ulrich, Rainer Detection of rat hepatitis E virus in wild Norway rats (Rattus norvegicus) and Black rats (Rattus rattus) from 11 European countries |
topic_facet |
Animal Distribution Male Humans Norway rat Phylogeny Animals Wild Black rat Europe Female Genotype 3 Hepatitis E Hepatitis E virus Hepeviridae Population Density Rats Species Specificity [SDV.IMM]Life Sciences [q-bio]/Immunology [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology |
description |
International audience Rat hepatitis E virus (HEV) is genetically only distantly related to hepeviruses found in other mammalian reservoirs and in humans. It was initially detected in Norway rats (Rattus norvegicus) from Germany, and subsequently in rats from Vietnam, the USA, Indonesia, China, Denmark and France. Here, we report on a molecular survey of Norway rats and Black rats (Rattus rattus) from 12 European countries for ratHEV and human pathogenic hepeviruses. RatHEV-specific real-time and conventional RT-PCR investigations revealed the presence of ratHEV in 63 of 508 (12.4%) rats at the majority of sites in 11 of 12 countries. In contrast, a real-time RT-PCR specific for human pathogenic HEV genotypes 1-4 and a nested broad-spectrum (NBS) RT-PCR with subsequent sequence determination did not detect any infections with these genotypes. Only in a single Norway rat from Belgium a rabbit HEV-like genotype 3 sequence was detected. Phylogenetic analysis indicated a clustering of all other novel Norway and Black rat-derived sequences with ratHEV sequences from Europe, the USA and a Black rat-derived sequence from Indonesia within the proposed ratHEV genotype 1. No difference in infection status was detected related to age, sex, rat species or density of human settlements and zoological gardens. In conclusion, our investigation shows a broad geographical distribution of ratHEV in Norway and Black rats from Europe and its presence in all settlement types investigated. |
author2 |
Friedrich-Loeffler-Institut (FLI) Institute for Medical Microbiology and Hygiene, Faculty of Medicine “Carl Gustav Carus” Technische Universität Dresden = Dresden University of Technology (TU Dresden) Virpath-Grippe, de l'émergence au contrôle -- Virpath-Influenza, from emergence to control (Virpath) Centre International de Recherche en Infectiologie - UMR (CIRI) École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL) Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL) Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) Bábolna Bio Ltd. Stadt Zürich, Umwelt- und Gesundheitsschutz Zürich AC Heiberg Rådgivning German Federal Institute for Risk Assessment Berlin (BfR) Institut für Medizinische Mikrobiologie - Institute of Medical Microbiology Justus-Liebig-Universität Gießen = Justus Liebig University (JLU) Senckenberg Museum of Natural History Görlitz Senckenberg – Leibniz Institution for Biodiversity and Earth System Research - Senckenberg Gesellschaft für Naturforschung Leibniz Association-Leibniz Association Task-Force Veterinärwesen Institute of Microbiology and Epizootics INBO Research Institute for Nature and Forest (INBO) Institut de recherche sur l'environnement (IREC) Ecole Polytechnique Fédérale de Lausanne (EPFL) University of Veterinary and Pharmaceutical Sciences Brno (VFU) CEITEC - Central European Institute of Technology Brno, Czech Republic Zaloška 4 Aristotle University of Thessaloniki Università degli studi di Torino = University of Turin (UNITO) Julius Kühn-Institute Institute of Ecology & Evolution (IEE) University of Bern Swiss Institute of Bioinformatics Lausanne (SIB) Université de Lausanne = University of Lausanne (UNIL) German Centre for Infection Research (DZIF) |
format |
Article in Journal/Newspaper |
author |
Ryll, René Bernstein, Samuel Heuser, Elisa Schlegel, Mathias Dremsek, Paul Zumpe, Maxi Wolf, Sandro Pépin, Michel Bajomi, Daniel Müller, Gabi Heiberg, Ann-Charlotte Spahr, Carina Lang, Johannes Groschup, Martin H. Ansorge, Hermann Freise, Jona Guenther, Sebastian Baert, Kristof Ruiz-Fons, Francisco Pikula, Jiri Knap, Nataša Tsakmakidis, Joannis Dovas, Chrysostomos Zanet, Stefania Imholt, Christian Heckel, Gerald Johne, Reimar Ulrich, Rainer |
author_facet |
Ryll, René Bernstein, Samuel Heuser, Elisa Schlegel, Mathias Dremsek, Paul Zumpe, Maxi Wolf, Sandro Pépin, Michel Bajomi, Daniel Müller, Gabi Heiberg, Ann-Charlotte Spahr, Carina Lang, Johannes Groschup, Martin H. Ansorge, Hermann Freise, Jona Guenther, Sebastian Baert, Kristof Ruiz-Fons, Francisco Pikula, Jiri Knap, Nataša Tsakmakidis, Joannis Dovas, Chrysostomos Zanet, Stefania Imholt, Christian Heckel, Gerald Johne, Reimar Ulrich, Rainer |
author_sort |
Ryll, René |
title |
Detection of rat hepatitis E virus in wild Norway rats (Rattus norvegicus) and Black rats (Rattus rattus) from 11 European countries |
title_short |
Detection of rat hepatitis E virus in wild Norway rats (Rattus norvegicus) and Black rats (Rattus rattus) from 11 European countries |
title_full |
Detection of rat hepatitis E virus in wild Norway rats (Rattus norvegicus) and Black rats (Rattus rattus) from 11 European countries |
title_fullStr |
Detection of rat hepatitis E virus in wild Norway rats (Rattus norvegicus) and Black rats (Rattus rattus) from 11 European countries |
title_full_unstemmed |
Detection of rat hepatitis E virus in wild Norway rats (Rattus norvegicus) and Black rats (Rattus rattus) from 11 European countries |
title_sort |
detection of rat hepatitis e virus in wild norway rats (rattus norvegicus) and black rats (rattus rattus) from 11 european countries |
publisher |
HAL CCSD |
publishDate |
2017 |
url |
https://hal.archives-ouvertes.fr/hal-01953659 https://doi.org/10.1016/j.vetmic.2017.07.001 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
ISSN: 0378-1135 Veterinary Microbiology https://hal.archives-ouvertes.fr/hal-01953659 Veterinary Microbiology, Elsevier, 2017, 208, pp.58-68. ⟨10.1016/j.vetmic.2017.07.001⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetmic.2017.07.001 info:eu-repo/semantics/altIdentifier/pmid/28888650 hal-01953659 https://hal.archives-ouvertes.fr/hal-01953659 doi:10.1016/j.vetmic.2017.07.001 PUBMED: 28888650 |
op_doi |
https://doi.org/10.1016/j.vetmic.2017.07.001 |
container_title |
Veterinary Microbiology |
container_volume |
208 |
container_start_page |
58 |
op_container_end_page |
68 |
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1766176583363592192 |
spelling |
ftunivnantes:oai:HAL:hal-01953659v1 2023-05-15T18:05:08+02:00 Detection of rat hepatitis E virus in wild Norway rats (Rattus norvegicus) and Black rats (Rattus rattus) from 11 European countries Ryll, René Bernstein, Samuel Heuser, Elisa Schlegel, Mathias Dremsek, Paul Zumpe, Maxi Wolf, Sandro Pépin, Michel Bajomi, Daniel Müller, Gabi Heiberg, Ann-Charlotte Spahr, Carina Lang, Johannes Groschup, Martin H. Ansorge, Hermann Freise, Jona Guenther, Sebastian Baert, Kristof Ruiz-Fons, Francisco Pikula, Jiri Knap, Nataša Tsakmakidis, Joannis Dovas, Chrysostomos Zanet, Stefania Imholt, Christian Heckel, Gerald Johne, Reimar Ulrich, Rainer Friedrich-Loeffler-Institut (FLI) Institute for Medical Microbiology and Hygiene, Faculty of Medicine “Carl Gustav Carus” Technische Universität Dresden = Dresden University of Technology (TU Dresden) Virpath-Grippe, de l'émergence au contrôle -- Virpath-Influenza, from emergence to control (Virpath) Centre International de Recherche en Infectiologie - UMR (CIRI) École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL) Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL) Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) Bábolna Bio Ltd. Stadt Zürich, Umwelt- und Gesundheitsschutz Zürich AC Heiberg Rådgivning German Federal Institute for Risk Assessment Berlin (BfR) Institut für Medizinische Mikrobiologie - Institute of Medical Microbiology Justus-Liebig-Universität Gießen = Justus Liebig University (JLU) Senckenberg Museum of Natural History Görlitz Senckenberg – Leibniz Institution for Biodiversity and Earth System Research - Senckenberg Gesellschaft für Naturforschung Leibniz Association-Leibniz Association Task-Force Veterinärwesen Institute of Microbiology and Epizootics INBO Research Institute for Nature and Forest (INBO) Institut de recherche sur l'environnement (IREC) Ecole Polytechnique Fédérale de Lausanne (EPFL) University of Veterinary and Pharmaceutical Sciences Brno (VFU) CEITEC - Central European Institute of Technology Brno, Czech Republic Zaloška 4 Aristotle University of Thessaloniki Università degli studi di Torino = University of Turin (UNITO) Julius Kühn-Institute Institute of Ecology & Evolution (IEE) University of Bern Swiss Institute of Bioinformatics Lausanne (SIB) Université de Lausanne = University of Lausanne (UNIL) German Centre for Infection Research (DZIF) 2017-09 https://hal.archives-ouvertes.fr/hal-01953659 https://doi.org/10.1016/j.vetmic.2017.07.001 en eng HAL CCSD Elsevier info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetmic.2017.07.001 info:eu-repo/semantics/altIdentifier/pmid/28888650 hal-01953659 https://hal.archives-ouvertes.fr/hal-01953659 doi:10.1016/j.vetmic.2017.07.001 PUBMED: 28888650 ISSN: 0378-1135 Veterinary Microbiology https://hal.archives-ouvertes.fr/hal-01953659 Veterinary Microbiology, Elsevier, 2017, 208, pp.58-68. ⟨10.1016/j.vetmic.2017.07.001⟩ Animal Distribution Male Humans Norway rat Phylogeny Animals Wild Black rat Europe Female Genotype 3 Hepatitis E Hepatitis E virus Hepeviridae Population Density Rats Species Specificity [SDV.IMM]Life Sciences [q-bio]/Immunology [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology info:eu-repo/semantics/article Journal articles 2017 ftunivnantes https://doi.org/10.1016/j.vetmic.2017.07.001 2022-10-19T00:00:48Z International audience Rat hepatitis E virus (HEV) is genetically only distantly related to hepeviruses found in other mammalian reservoirs and in humans. It was initially detected in Norway rats (Rattus norvegicus) from Germany, and subsequently in rats from Vietnam, the USA, Indonesia, China, Denmark and France. Here, we report on a molecular survey of Norway rats and Black rats (Rattus rattus) from 12 European countries for ratHEV and human pathogenic hepeviruses. RatHEV-specific real-time and conventional RT-PCR investigations revealed the presence of ratHEV in 63 of 508 (12.4%) rats at the majority of sites in 11 of 12 countries. In contrast, a real-time RT-PCR specific for human pathogenic HEV genotypes 1-4 and a nested broad-spectrum (NBS) RT-PCR with subsequent sequence determination did not detect any infections with these genotypes. Only in a single Norway rat from Belgium a rabbit HEV-like genotype 3 sequence was detected. Phylogenetic analysis indicated a clustering of all other novel Norway and Black rat-derived sequences with ratHEV sequences from Europe, the USA and a Black rat-derived sequence from Indonesia within the proposed ratHEV genotype 1. No difference in infection status was detected related to age, sex, rat species or density of human settlements and zoological gardens. In conclusion, our investigation shows a broad geographical distribution of ratHEV in Norway and Black rats from Europe and its presence in all settlement types investigated. Article in Journal/Newspaper Rattus rattus Université de Nantes: HAL-UNIV-NANTES Norway Veterinary Microbiology 208 58 68 |