Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans
Cetacean body structure and physiology exhibit dramatic adaptations to their aquatic environment. Fibroblast growth factors (FGFs) are a family of essential factors that regulate animal development and physiology; however, their role in cetacean evolution is not clearly understood. Here, we sequence...
Published in: | Scientific Reports |
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Format: | Article in Journal/Newspaper |
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ftunivnantes:oai:HAL:hal-01605138v1 2023-05-15T16:13:19+02:00 Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans Nam, Ki Woong Lee, Kyeong Won Chung, Oksung Yim, Hyung-Soon Cha, Sun-Shin Lee, Sae-Won Jun, Jehoon Cho, Yun Sung Bhak, Jong de Magalhaes, Joao Pedro Lee, Jung-Hyun Jeong, Jae-Yeon Diversité, Génomes & Interactions Microorganismes - Insectes Montpellier (DGIMI) Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM) Marine Biotechnology Research Center Korea Institute of Ocean Science and Technology (KIOST) Personal Genomics Institute Genome Research Foundation Department of Marine Biotechnology Korea University of Science and Technology Department of Chemistry and Nano Science EWHA Womans University (EWHA) Biomedical Research Institute and IRICT Seoul National University Hospital Biomedical Engineering Department King‘s College London Institute of Integrative Biology Korea Institute of Ocean Science & Technology (KIOST) PE99413); National Research Foundation of Korea NRF-2015R1A2A2A01004168 Reference genomes building and application for large scale population genomics' Research Fund of Ulsan National Institute of Science & Technology (UINST) 1.160003.01 2017 https://hal.archives-ouvertes.fr/hal-01605138 https://hal.archives-ouvertes.fr/hal-01605138/document https://hal.archives-ouvertes.fr/hal-01605138/file/2017_Nam_Scientific%20Reports_1.pdf https://doi.org/10.1038/srep40233 en eng HAL CCSD Nature Publishing Group info:eu-repo/semantics/altIdentifier/doi/10.1038/srep40233 info:eu-repo/semantics/altIdentifier/pmid/28074842 hal-01605138 https://hal.archives-ouvertes.fr/hal-01605138 https://hal.archives-ouvertes.fr/hal-01605138/document https://hal.archives-ouvertes.fr/hal-01605138/file/2017_Nam_Scientific%20Reports_1.pdf doi:10.1038/srep40233 PRODINRA: 396314 PUBMED: 28074842 WOS: 000391534500001 info:eu-repo/semantics/OpenAccess ISSN: 2045-2322 EISSN: 2045-2322 Scientific Reports https://hal.archives-ouvertes.fr/hal-01605138 Scientific Reports, Nature Publishing Group, 2017, 7, pp.13. ⟨10.1038/srep40233⟩ cetacean whale cetace densité osseuse baleine milieu aquatique séquençage du génome physiologie animale pseudogénisation [SDE.BE]Environmental Sciences/Biodiversity and Ecology info:eu-repo/semantics/article Journal articles 2017 ftunivnantes https://doi.org/10.1038/srep40233 2022-08-10T04:06:32Z Cetacean body structure and physiology exhibit dramatic adaptations to their aquatic environment. Fibroblast growth factors (FGFs) are a family of essential factors that regulate animal development and physiology; however, their role in cetacean evolution is not clearly understood. Here, we sequenced the fin whale genome and analysed FGFs from 8 cetaceans. FGF22, a hair follicle-enriched gene, exhibited pseudogenization, indicating that the function of this gene is no longer necessary in cetaceans that have lost most of their body hair. An evolutionary analysis revealed signatures of positive selection for FGF3 and FGF11, genes related to ear and tooth development and hypoxia, respectively. We found a D203G substitution in cetacean FGF9, which was predicted to affect FGF9 homodimerization, suggesting that this gene plays a role in the acquisition of rigid flippers for efficient manoeuvring. Cetaceans utilize low bone density as a buoyancy control mechanism, but the underlying genes are not known. We found that the expression of FGF23, a gene associated with reduced bone density, is greatly increased in the cetacean liver under hypoxic conditions, thus implicating FGF23 in low bone density in cetaceans. Altogether, our results provide novel insights into the roles of FGFs in cetacean adaptation to the aquatic environment. Article in Journal/Newspaper Fin whale Université de Nantes: HAL-UNIV-NANTES Baleine ENVELOPE(140.012,140.012,-66.649,-66.649) Scientific Reports 7 1 |
institution |
Open Polar |
collection |
Université de Nantes: HAL-UNIV-NANTES |
op_collection_id |
ftunivnantes |
language |
English |
topic |
cetacean whale cetace densité osseuse baleine milieu aquatique séquençage du génome physiologie animale pseudogénisation [SDE.BE]Environmental Sciences/Biodiversity and Ecology |
spellingShingle |
cetacean whale cetace densité osseuse baleine milieu aquatique séquençage du génome physiologie animale pseudogénisation [SDE.BE]Environmental Sciences/Biodiversity and Ecology Nam, Ki Woong Lee, Kyeong Won Chung, Oksung Yim, Hyung-Soon Cha, Sun-Shin Lee, Sae-Won Jun, Jehoon Cho, Yun Sung Bhak, Jong de Magalhaes, Joao Pedro Lee, Jung-Hyun Jeong, Jae-Yeon Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans |
topic_facet |
cetacean whale cetace densité osseuse baleine milieu aquatique séquençage du génome physiologie animale pseudogénisation [SDE.BE]Environmental Sciences/Biodiversity and Ecology |
description |
Cetacean body structure and physiology exhibit dramatic adaptations to their aquatic environment. Fibroblast growth factors (FGFs) are a family of essential factors that regulate animal development and physiology; however, their role in cetacean evolution is not clearly understood. Here, we sequenced the fin whale genome and analysed FGFs from 8 cetaceans. FGF22, a hair follicle-enriched gene, exhibited pseudogenization, indicating that the function of this gene is no longer necessary in cetaceans that have lost most of their body hair. An evolutionary analysis revealed signatures of positive selection for FGF3 and FGF11, genes related to ear and tooth development and hypoxia, respectively. We found a D203G substitution in cetacean FGF9, which was predicted to affect FGF9 homodimerization, suggesting that this gene plays a role in the acquisition of rigid flippers for efficient manoeuvring. Cetaceans utilize low bone density as a buoyancy control mechanism, but the underlying genes are not known. We found that the expression of FGF23, a gene associated with reduced bone density, is greatly increased in the cetacean liver under hypoxic conditions, thus implicating FGF23 in low bone density in cetaceans. Altogether, our results provide novel insights into the roles of FGFs in cetacean adaptation to the aquatic environment. |
author2 |
Diversité, Génomes & Interactions Microorganismes - Insectes Montpellier (DGIMI) Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM) Marine Biotechnology Research Center Korea Institute of Ocean Science and Technology (KIOST) Personal Genomics Institute Genome Research Foundation Department of Marine Biotechnology Korea University of Science and Technology Department of Chemistry and Nano Science EWHA Womans University (EWHA) Biomedical Research Institute and IRICT Seoul National University Hospital Biomedical Engineering Department King‘s College London Institute of Integrative Biology Korea Institute of Ocean Science & Technology (KIOST) PE99413); National Research Foundation of Korea NRF-2015R1A2A2A01004168 Reference genomes building and application for large scale population genomics' Research Fund of Ulsan National Institute of Science & Technology (UINST) 1.160003.01 |
format |
Article in Journal/Newspaper |
author |
Nam, Ki Woong Lee, Kyeong Won Chung, Oksung Yim, Hyung-Soon Cha, Sun-Shin Lee, Sae-Won Jun, Jehoon Cho, Yun Sung Bhak, Jong de Magalhaes, Joao Pedro Lee, Jung-Hyun Jeong, Jae-Yeon |
author_facet |
Nam, Ki Woong Lee, Kyeong Won Chung, Oksung Yim, Hyung-Soon Cha, Sun-Shin Lee, Sae-Won Jun, Jehoon Cho, Yun Sung Bhak, Jong de Magalhaes, Joao Pedro Lee, Jung-Hyun Jeong, Jae-Yeon |
author_sort |
Nam, Ki Woong |
title |
Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans |
title_short |
Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans |
title_full |
Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans |
title_fullStr |
Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans |
title_full_unstemmed |
Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans |
title_sort |
analysis of the fgf gene family provides insights into aquatic adaptation in cetaceans |
publisher |
HAL CCSD |
publishDate |
2017 |
url |
https://hal.archives-ouvertes.fr/hal-01605138 https://hal.archives-ouvertes.fr/hal-01605138/document https://hal.archives-ouvertes.fr/hal-01605138/file/2017_Nam_Scientific%20Reports_1.pdf https://doi.org/10.1038/srep40233 |
long_lat |
ENVELOPE(140.012,140.012,-66.649,-66.649) |
geographic |
Baleine |
geographic_facet |
Baleine |
genre |
Fin whale |
genre_facet |
Fin whale |
op_source |
ISSN: 2045-2322 EISSN: 2045-2322 Scientific Reports https://hal.archives-ouvertes.fr/hal-01605138 Scientific Reports, Nature Publishing Group, 2017, 7, pp.13. ⟨10.1038/srep40233⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1038/srep40233 info:eu-repo/semantics/altIdentifier/pmid/28074842 hal-01605138 https://hal.archives-ouvertes.fr/hal-01605138 https://hal.archives-ouvertes.fr/hal-01605138/document https://hal.archives-ouvertes.fr/hal-01605138/file/2017_Nam_Scientific%20Reports_1.pdf doi:10.1038/srep40233 PRODINRA: 396314 PUBMED: 28074842 WOS: 000391534500001 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1038/srep40233 |
container_title |
Scientific Reports |
container_volume |
7 |
container_issue |
1 |
_version_ |
1765998990510260224 |