Effects of a parental exposure to diuron on Pacific oyster spat methylome
International audience Environmental epigenetic is an emerging field that studies the cause–effect relationship between environmental factors and heritable trait via an alteration in epigenetic marks. This field has received much attentions since the impact of environmental factors on different epig...
Published in: | Environmental Epigenetics |
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Online Access: | https://hal.archives-ouvertes.fr/hal-01511486 https://hal.archives-ouvertes.fr/hal-01511486/document https://hal.archives-ouvertes.fr/hal-01511486/file/Rondon-2017-EnvirEpig-Effects.pdf https://doi.org/10.1093/eep/dvx004 |
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ftunivnantes:oai:HAL:hal-01511486v1 2023-05-15T15:58:58+02:00 Effects of a parental exposure to diuron on Pacific oyster spat methylome Rondon, Rodolfo Grunau, Christoph Fallet, Manon Charlemagne, Nicolas Sussarellu, Rossana Chaparro, Cristian Montagnani, Caroline Mitta, Guillaume Bachère, Evelyne Akcha, Farida Cosseau, Céline Interactions Hôtes-Pathogènes-Environnements (IHPE) Université de Perpignan Via Domitia (UPVD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM) Laboratoire d'Écotoxicologie (LEX) Biogéochimie et Ecotoxicologie (BE) Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) 2017 https://hal.archives-ouvertes.fr/hal-01511486 https://hal.archives-ouvertes.fr/hal-01511486/document https://hal.archives-ouvertes.fr/hal-01511486/file/Rondon-2017-EnvirEpig-Effects.pdf https://doi.org/10.1093/eep/dvx004 en eng HAL CCSD Oxford University Press info:eu-repo/semantics/altIdentifier/doi/10.1093/eep/dvx004 hal-01511486 https://hal.archives-ouvertes.fr/hal-01511486 https://hal.archives-ouvertes.fr/hal-01511486/document https://hal.archives-ouvertes.fr/hal-01511486/file/Rondon-2017-EnvirEpig-Effects.pdf doi:10.1093/eep/dvx004 info:eu-repo/semantics/OpenAccess ISSN: 2058-5888 EISSN: 2058-5888 Environmental Epigenetics https://hal.archives-ouvertes.fr/hal-01511486 Environmental Epigenetics, 2017, 3 (1), pp.dvx004. ⟨10.1093/eep/dvx004⟩ https://doi.org/10.1093/eep/dvx004 Crassostrea gigas mollusk DNA methylation herbicide epigenetic [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] info:eu-repo/semantics/article Journal articles 2017 ftunivnantes https://doi.org/10.1093/eep/dvx004 2022-12-07T02:22:37Z International audience Environmental epigenetic is an emerging field that studies the cause–effect relationship between environmental factors and heritable trait via an alteration in epigenetic marks. This field has received much attentions since the impact of environmental factors on different epigenetic marks have been shown to be associated with a broad range of phenotypic disorders in natural ecosystems. Chemical pollutants have been shown to affect immediate epigenetic information carriers of several aquatic species but the heritability of the chromatin marks and the consequences for long term adaptation remain open questions. In this work, we investigated the impact of the diuron herbicide on the DNA methylation pattern of spat from exposed Crassotrea gigas genitors. This oyster is one of the most important mollusk species produced worldwide and a key coastal economic resource in France. The whole genome bisulfite sequencing (WGBS, BS-Seq) was applied to obtain a methylome at single nucleotide resolution on DNA extracted from spat issued from diuron exposed genitors comparatively to control spat. We showed that the parental diuron exposure has an impact on the DNA methylation pattern of its progeny. Most of the differentially methylated regions occurred within coding sequences and we showed that this change in methyl-ation level correlates with RNA level only in a very small group of genes. Although the DNA methylation profile is variable between individuals, we showed conserved DNA methylation patterns in response to parental diuron exposure. This relevant result opens perspectives for the setting of new markers based on epimutations as early indicators of marine pollutions. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Université de Nantes: HAL-UNIV-NANTES Pacific Environmental Epigenetics 3 1 |
institution |
Open Polar |
collection |
Université de Nantes: HAL-UNIV-NANTES |
op_collection_id |
ftunivnantes |
language |
English |
topic |
Crassostrea gigas mollusk DNA methylation herbicide epigenetic [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] |
spellingShingle |
Crassostrea gigas mollusk DNA methylation herbicide epigenetic [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] Rondon, Rodolfo Grunau, Christoph Fallet, Manon Charlemagne, Nicolas Sussarellu, Rossana Chaparro, Cristian Montagnani, Caroline Mitta, Guillaume Bachère, Evelyne Akcha, Farida Cosseau, Céline Effects of a parental exposure to diuron on Pacific oyster spat methylome |
topic_facet |
Crassostrea gigas mollusk DNA methylation herbicide epigenetic [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] |
description |
International audience Environmental epigenetic is an emerging field that studies the cause–effect relationship between environmental factors and heritable trait via an alteration in epigenetic marks. This field has received much attentions since the impact of environmental factors on different epigenetic marks have been shown to be associated with a broad range of phenotypic disorders in natural ecosystems. Chemical pollutants have been shown to affect immediate epigenetic information carriers of several aquatic species but the heritability of the chromatin marks and the consequences for long term adaptation remain open questions. In this work, we investigated the impact of the diuron herbicide on the DNA methylation pattern of spat from exposed Crassotrea gigas genitors. This oyster is one of the most important mollusk species produced worldwide and a key coastal economic resource in France. The whole genome bisulfite sequencing (WGBS, BS-Seq) was applied to obtain a methylome at single nucleotide resolution on DNA extracted from spat issued from diuron exposed genitors comparatively to control spat. We showed that the parental diuron exposure has an impact on the DNA methylation pattern of its progeny. Most of the differentially methylated regions occurred within coding sequences and we showed that this change in methyl-ation level correlates with RNA level only in a very small group of genes. Although the DNA methylation profile is variable between individuals, we showed conserved DNA methylation patterns in response to parental diuron exposure. This relevant result opens perspectives for the setting of new markers based on epimutations as early indicators of marine pollutions. |
author2 |
Interactions Hôtes-Pathogènes-Environnements (IHPE) Université de Perpignan Via Domitia (UPVD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM) Laboratoire d'Écotoxicologie (LEX) Biogéochimie et Ecotoxicologie (BE) Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) |
format |
Article in Journal/Newspaper |
author |
Rondon, Rodolfo Grunau, Christoph Fallet, Manon Charlemagne, Nicolas Sussarellu, Rossana Chaparro, Cristian Montagnani, Caroline Mitta, Guillaume Bachère, Evelyne Akcha, Farida Cosseau, Céline |
author_facet |
Rondon, Rodolfo Grunau, Christoph Fallet, Manon Charlemagne, Nicolas Sussarellu, Rossana Chaparro, Cristian Montagnani, Caroline Mitta, Guillaume Bachère, Evelyne Akcha, Farida Cosseau, Céline |
author_sort |
Rondon, Rodolfo |
title |
Effects of a parental exposure to diuron on Pacific oyster spat methylome |
title_short |
Effects of a parental exposure to diuron on Pacific oyster spat methylome |
title_full |
Effects of a parental exposure to diuron on Pacific oyster spat methylome |
title_fullStr |
Effects of a parental exposure to diuron on Pacific oyster spat methylome |
title_full_unstemmed |
Effects of a parental exposure to diuron on Pacific oyster spat methylome |
title_sort |
effects of a parental exposure to diuron on pacific oyster spat methylome |
publisher |
HAL CCSD |
publishDate |
2017 |
url |
https://hal.archives-ouvertes.fr/hal-01511486 https://hal.archives-ouvertes.fr/hal-01511486/document https://hal.archives-ouvertes.fr/hal-01511486/file/Rondon-2017-EnvirEpig-Effects.pdf https://doi.org/10.1093/eep/dvx004 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
ISSN: 2058-5888 EISSN: 2058-5888 Environmental Epigenetics https://hal.archives-ouvertes.fr/hal-01511486 Environmental Epigenetics, 2017, 3 (1), pp.dvx004. ⟨10.1093/eep/dvx004⟩ https://doi.org/10.1093/eep/dvx004 |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1093/eep/dvx004 hal-01511486 https://hal.archives-ouvertes.fr/hal-01511486 https://hal.archives-ouvertes.fr/hal-01511486/document https://hal.archives-ouvertes.fr/hal-01511486/file/Rondon-2017-EnvirEpig-Effects.pdf doi:10.1093/eep/dvx004 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1093/eep/dvx004 |
container_title |
Environmental Epigenetics |
container_volume |
3 |
container_issue |
1 |
_version_ |
1766394741548646400 |