QTL detection for Aeromonas salmonicida resistance related traits in turbot (Scophthalmus maximus)
Interactions between fish and pathogens, that may be harmless under natural conditions, often result in serious diseases in aquaculture systems. This is especially important due to the fact that the strains used in aquaculture are derived from wild strains that may not have had enough time to adapt...
Published in: | BMC Genomics |
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2011
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Online Access: | https://hal.archives-ouvertes.fr/hal-01466970 https://hal.archives-ouvertes.fr/hal-01466970/document https://hal.archives-ouvertes.fr/hal-01466970/file/2011_Rodr%C3%ADguez_Ramilo_BMC_Genomics_1.pdf https://doi.org/10.1186/1471-2164-12-541 |
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ftunivnantes:oai:HAL:hal-01466970v1 2023-05-15T15:32:54+02:00 QTL detection for Aeromonas salmonicida resistance related traits in turbot (Scophthalmus maximus) Rodríguez-Ramilo, Silvia Teresa Toro, Miguel A. Bouza, Carmen Hermida, Miguel Pardo, Belen G. Cabaleiro, Santiago Martínez, Paulino Fernández, Jesus Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (INIA) Dept Anim Prod Universidad Politécnica de Madrid (UPM) Universidade de Santiago de Compostela Spain (USC ) Cluster Acuicultura Galicia (CETGA) 2011 https://hal.archives-ouvertes.fr/hal-01466970 https://hal.archives-ouvertes.fr/hal-01466970/document https://hal.archives-ouvertes.fr/hal-01466970/file/2011_Rodr%C3%ADguez_Ramilo_BMC_Genomics_1.pdf https://doi.org/10.1186/1471-2164-12-541 en eng HAL CCSD BioMed Central info:eu-repo/semantics/altIdentifier/doi/10.1186/1471-2164-12-541 info:eu-repo/semantics/altIdentifier/pmid/22047500 hal-01466970 https://hal.archives-ouvertes.fr/hal-01466970 https://hal.archives-ouvertes.fr/hal-01466970/document https://hal.archives-ouvertes.fr/hal-01466970/file/2011_Rodr%C3%ADguez_Ramilo_BMC_Genomics_1.pdf doi:10.1186/1471-2164-12-541 PRODINRA: 372760 PUBMED: 22047500 WOS: 000297050900001 http://hal.archives-ouvertes.fr/licences/copyright/ info:eu-repo/semantics/OpenAccess EISSN: 1471-2164 BMC Genomics https://hal.archives-ouvertes.fr/hal-01466970 BMC Genomics, BioMed Central, 2011, 12, pp.Non Paginé. ⟨10.1186/1471-2164-12-541⟩ infectious pancreatic necrosis atlantic salmon rainbow-trout genetic marker hematopoietic necrosis ihn virus-resistance [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2011 ftunivnantes https://doi.org/10.1186/1471-2164-12-541 2022-08-10T03:58:18Z Interactions between fish and pathogens, that may be harmless under natural conditions, often result in serious diseases in aquaculture systems. This is especially important due to the fact that the strains used in aquaculture are derived from wild strains that may not have had enough time to adapt to new disease pressures. The turbot is one of the most promising European aquaculture species. Furunculosis, caused by the bacterium Aeromonas salmonicida, produces important losses to turbot industry. An appealing solution is to achieve more robust broodstock, which can prevent or diminish the devastating effects of epizooties. Genomics strategies have been developed in turbot to look for candidate genes for resistance to furunculosis and a genetic map with appropriate density to screen for genomic associations has been also constructed. In the present study, a genome scan for QTL affecting resistance and survival to A. salmonicida in four turbot families was carried out. The objectives were to identify consistent QTL using different statistical approaches (linear regression and maximum likelihood) and to locate the tightest associated markers for their application in genetic breeding strategies.Significant QTL for resistance were identified by the linear regression method in three linkage groups (LGs 4, 6 and 9) and for survival in two LGs (6 and 9). The maximum likelihood methodology identified QTL in three LGs (5, 6 and 9) for both traits. Significant association between disease traits and genotypes was detected for several markers, some of them explaining up to 17% of the phenotypic variance. We also identified candidate genes located in the detected QTL using data from previously mapped markers.Several regions controlling resistance to A. salmonicida in turbot have been detected. The observed concordance between different statistical methods at particular linkage groups gives consistency to our results. The detected associated markers could be useful for genetic breeding strategies. A finer mapping will be ... Article in Journal/Newspaper Atlantic salmon Scophthalmus maximus Turbot Université de Nantes: HAL-UNIV-NANTES BMC Genomics 12 1 |
institution |
Open Polar |
collection |
Université de Nantes: HAL-UNIV-NANTES |
op_collection_id |
ftunivnantes |
language |
English |
topic |
infectious pancreatic necrosis atlantic salmon rainbow-trout genetic marker hematopoietic necrosis ihn virus-resistance [SDV]Life Sciences [q-bio] |
spellingShingle |
infectious pancreatic necrosis atlantic salmon rainbow-trout genetic marker hematopoietic necrosis ihn virus-resistance [SDV]Life Sciences [q-bio] Rodríguez-Ramilo, Silvia Teresa Toro, Miguel A. Bouza, Carmen Hermida, Miguel Pardo, Belen G. Cabaleiro, Santiago Martínez, Paulino Fernández, Jesus QTL detection for Aeromonas salmonicida resistance related traits in turbot (Scophthalmus maximus) |
topic_facet |
infectious pancreatic necrosis atlantic salmon rainbow-trout genetic marker hematopoietic necrosis ihn virus-resistance [SDV]Life Sciences [q-bio] |
description |
Interactions between fish and pathogens, that may be harmless under natural conditions, often result in serious diseases in aquaculture systems. This is especially important due to the fact that the strains used in aquaculture are derived from wild strains that may not have had enough time to adapt to new disease pressures. The turbot is one of the most promising European aquaculture species. Furunculosis, caused by the bacterium Aeromonas salmonicida, produces important losses to turbot industry. An appealing solution is to achieve more robust broodstock, which can prevent or diminish the devastating effects of epizooties. Genomics strategies have been developed in turbot to look for candidate genes for resistance to furunculosis and a genetic map with appropriate density to screen for genomic associations has been also constructed. In the present study, a genome scan for QTL affecting resistance and survival to A. salmonicida in four turbot families was carried out. The objectives were to identify consistent QTL using different statistical approaches (linear regression and maximum likelihood) and to locate the tightest associated markers for their application in genetic breeding strategies.Significant QTL for resistance were identified by the linear regression method in three linkage groups (LGs 4, 6 and 9) and for survival in two LGs (6 and 9). The maximum likelihood methodology identified QTL in three LGs (5, 6 and 9) for both traits. Significant association between disease traits and genotypes was detected for several markers, some of them explaining up to 17% of the phenotypic variance. We also identified candidate genes located in the detected QTL using data from previously mapped markers.Several regions controlling resistance to A. salmonicida in turbot have been detected. The observed concordance between different statistical methods at particular linkage groups gives consistency to our results. The detected associated markers could be useful for genetic breeding strategies. A finer mapping will be ... |
author2 |
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (INIA) Dept Anim Prod Universidad Politécnica de Madrid (UPM) Universidade de Santiago de Compostela Spain (USC ) Cluster Acuicultura Galicia (CETGA) |
format |
Article in Journal/Newspaper |
author |
Rodríguez-Ramilo, Silvia Teresa Toro, Miguel A. Bouza, Carmen Hermida, Miguel Pardo, Belen G. Cabaleiro, Santiago Martínez, Paulino Fernández, Jesus |
author_facet |
Rodríguez-Ramilo, Silvia Teresa Toro, Miguel A. Bouza, Carmen Hermida, Miguel Pardo, Belen G. Cabaleiro, Santiago Martínez, Paulino Fernández, Jesus |
author_sort |
Rodríguez-Ramilo, Silvia Teresa |
title |
QTL detection for Aeromonas salmonicida resistance related traits in turbot (Scophthalmus maximus) |
title_short |
QTL detection for Aeromonas salmonicida resistance related traits in turbot (Scophthalmus maximus) |
title_full |
QTL detection for Aeromonas salmonicida resistance related traits in turbot (Scophthalmus maximus) |
title_fullStr |
QTL detection for Aeromonas salmonicida resistance related traits in turbot (Scophthalmus maximus) |
title_full_unstemmed |
QTL detection for Aeromonas salmonicida resistance related traits in turbot (Scophthalmus maximus) |
title_sort |
qtl detection for aeromonas salmonicida resistance related traits in turbot (scophthalmus maximus) |
publisher |
HAL CCSD |
publishDate |
2011 |
url |
https://hal.archives-ouvertes.fr/hal-01466970 https://hal.archives-ouvertes.fr/hal-01466970/document https://hal.archives-ouvertes.fr/hal-01466970/file/2011_Rodr%C3%ADguez_Ramilo_BMC_Genomics_1.pdf https://doi.org/10.1186/1471-2164-12-541 |
genre |
Atlantic salmon Scophthalmus maximus Turbot |
genre_facet |
Atlantic salmon Scophthalmus maximus Turbot |
op_source |
EISSN: 1471-2164 BMC Genomics https://hal.archives-ouvertes.fr/hal-01466970 BMC Genomics, BioMed Central, 2011, 12, pp.Non Paginé. ⟨10.1186/1471-2164-12-541⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1186/1471-2164-12-541 info:eu-repo/semantics/altIdentifier/pmid/22047500 hal-01466970 https://hal.archives-ouvertes.fr/hal-01466970 https://hal.archives-ouvertes.fr/hal-01466970/document https://hal.archives-ouvertes.fr/hal-01466970/file/2011_Rodr%C3%ADguez_Ramilo_BMC_Genomics_1.pdf doi:10.1186/1471-2164-12-541 PRODINRA: 372760 PUBMED: 22047500 WOS: 000297050900001 |
op_rights |
http://hal.archives-ouvertes.fr/licences/copyright/ info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1186/1471-2164-12-541 |
container_title |
BMC Genomics |
container_volume |
12 |
container_issue |
1 |
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1766363371283677184 |