How Cadmium could compromise the completion of the European eel's reproductive migration
International audience The European eel (Anguilla anguilla L.) is severely threatened with extinction. Surprisingly, even though their unusual life cycle makes them particularly vulnerable to pollution, the possible contribution of contamination remains especially poorly known. Here we have investig...
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ftunivnantes:oai:HAL:hal-00384733v1 2023-05-15T13:28:01+02:00 How Cadmium could compromise the completion of the European eel's reproductive migration Pierron, Fabien Baudrimont, Magalie Dufour, Sylvie Elie, Pierre Bossy, Angélique Baloche, Sylvie Mesmer-Dudons, Nathalie Gonzalez, Patrice Bourdineaud, Jean-Paul Massabuau, Jean-Charles Biologie des organismes marins et écosystèmes (BOME) Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS) 2008 https://hal.science/hal-00384733 https://doi.org/10.1021/es703127c en eng HAL CCSD American Chemical Society info:eu-repo/semantics/altIdentifier/doi/10.1021/es703127c hal-00384733 https://hal.science/hal-00384733 doi:10.1021/es703127c ISSN: 0013-936X EISSN: 1520-5851 Environmental Science and Technology https://hal.science/hal-00384733 Environmental Science and Technology, 2008, 42, pp.4607-4612. ⟨10.1021/es703127c⟩ [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology [SDV.TOX]Life Sciences [q-bio]/Toxicology [SDV.EE]Life Sciences [q-bio]/Ecology environment info:eu-repo/semantics/article Journal articles 2008 ftunivnantes https://doi.org/10.1021/es703127c 2023-02-08T02:12:26Z International audience The European eel (Anguilla anguilla L.) is severely threatened with extinction. Surprisingly, even though their unusual life cycle makes them particularly vulnerable to pollution, the possible contribution of contamination remains especially poorly known. Here we have investigated the possible effect of cadmium (Cd), a widespread nonessential metal, on eel reproductive capacities. Both control and Cd precontaminated female silver eels were experimentally matured and forced to swim in metal-free conditions to mimic their reproductive migration. Cd pre-exposure was found to strongly stimulate the pituitary−gonad−liver axis of maturing female silver eels leading to early and enhanced vitellogenesis. This was followed by a strong phenomenon of oocyte atresia and eel mortality. These phenomena occurred before oocytes could reach full maturation and were associated with a large entry of both vitellogenin and Cd into the ovaries. Indeed, a redistribution of previously stored cadmium, even from the low Cd levels of control eels, was observed during sexual maturation. Atresia and mortality phenomena were also associated with an overexpression of the pituitary gene encoding the growth hormone, a marker of physiological stress and energy reserves exhaustion. Significantly, these devastating effects of Cd were observed in organisms that presented liver and kidney Cd concentrations still below those observed in eels from Cd contaminated hydrosystems. Our research shows how common levels of cadmium contamination could disrupt endocrine pathways implicated in gonad maturation and subsequently impair reproductive capacity of eel future genitors Article in Journal/Newspaper Anguilla anguilla Université de Nantes: HAL-UNIV-NANTES Environmental Science & Technology 42 12 4607 4612 |
institution |
Open Polar |
collection |
Université de Nantes: HAL-UNIV-NANTES |
op_collection_id |
ftunivnantes |
language |
English |
topic |
[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology [SDV.TOX]Life Sciences [q-bio]/Toxicology [SDV.EE]Life Sciences [q-bio]/Ecology environment |
spellingShingle |
[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology [SDV.TOX]Life Sciences [q-bio]/Toxicology [SDV.EE]Life Sciences [q-bio]/Ecology environment Pierron, Fabien Baudrimont, Magalie Dufour, Sylvie Elie, Pierre Bossy, Angélique Baloche, Sylvie Mesmer-Dudons, Nathalie Gonzalez, Patrice Bourdineaud, Jean-Paul Massabuau, Jean-Charles How Cadmium could compromise the completion of the European eel's reproductive migration |
topic_facet |
[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology [SDV.TOX]Life Sciences [q-bio]/Toxicology [SDV.EE]Life Sciences [q-bio]/Ecology environment |
description |
International audience The European eel (Anguilla anguilla L.) is severely threatened with extinction. Surprisingly, even though their unusual life cycle makes them particularly vulnerable to pollution, the possible contribution of contamination remains especially poorly known. Here we have investigated the possible effect of cadmium (Cd), a widespread nonessential metal, on eel reproductive capacities. Both control and Cd precontaminated female silver eels were experimentally matured and forced to swim in metal-free conditions to mimic their reproductive migration. Cd pre-exposure was found to strongly stimulate the pituitary−gonad−liver axis of maturing female silver eels leading to early and enhanced vitellogenesis. This was followed by a strong phenomenon of oocyte atresia and eel mortality. These phenomena occurred before oocytes could reach full maturation and were associated with a large entry of both vitellogenin and Cd into the ovaries. Indeed, a redistribution of previously stored cadmium, even from the low Cd levels of control eels, was observed during sexual maturation. Atresia and mortality phenomena were also associated with an overexpression of the pituitary gene encoding the growth hormone, a marker of physiological stress and energy reserves exhaustion. Significantly, these devastating effects of Cd were observed in organisms that presented liver and kidney Cd concentrations still below those observed in eels from Cd contaminated hydrosystems. Our research shows how common levels of cadmium contamination could disrupt endocrine pathways implicated in gonad maturation and subsequently impair reproductive capacity of eel future genitors |
author2 |
Biologie des organismes marins et écosystèmes (BOME) Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS) |
format |
Article in Journal/Newspaper |
author |
Pierron, Fabien Baudrimont, Magalie Dufour, Sylvie Elie, Pierre Bossy, Angélique Baloche, Sylvie Mesmer-Dudons, Nathalie Gonzalez, Patrice Bourdineaud, Jean-Paul Massabuau, Jean-Charles |
author_facet |
Pierron, Fabien Baudrimont, Magalie Dufour, Sylvie Elie, Pierre Bossy, Angélique Baloche, Sylvie Mesmer-Dudons, Nathalie Gonzalez, Patrice Bourdineaud, Jean-Paul Massabuau, Jean-Charles |
author_sort |
Pierron, Fabien |
title |
How Cadmium could compromise the completion of the European eel's reproductive migration |
title_short |
How Cadmium could compromise the completion of the European eel's reproductive migration |
title_full |
How Cadmium could compromise the completion of the European eel's reproductive migration |
title_fullStr |
How Cadmium could compromise the completion of the European eel's reproductive migration |
title_full_unstemmed |
How Cadmium could compromise the completion of the European eel's reproductive migration |
title_sort |
how cadmium could compromise the completion of the european eel's reproductive migration |
publisher |
HAL CCSD |
publishDate |
2008 |
url |
https://hal.science/hal-00384733 https://doi.org/10.1021/es703127c |
genre |
Anguilla anguilla |
genre_facet |
Anguilla anguilla |
op_source |
ISSN: 0013-936X EISSN: 1520-5851 Environmental Science and Technology https://hal.science/hal-00384733 Environmental Science and Technology, 2008, 42, pp.4607-4612. ⟨10.1021/es703127c⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1021/es703127c hal-00384733 https://hal.science/hal-00384733 doi:10.1021/es703127c |
op_doi |
https://doi.org/10.1021/es703127c |
container_title |
Environmental Science & Technology |
container_volume |
42 |
container_issue |
12 |
container_start_page |
4607 |
op_container_end_page |
4612 |
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1766401765166546944 |