The fabp4 gene of zebrafish (Danio rerio)--genomic homology with the mammalian FABP4 and divergence from the zebrafish fabp3 in developmental expression.
Teleost fishes differ from mammals in their fat deposition and distribution. The gene for adipocyte-type fatty acid-binding protein (A-FABP or FABP4) has not been identified thus far in fishes. We have determined the cDNA sequence and defined the structure of a fatty acid-binding protein gene (desig...
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ftunivnantes:oai:HAL:hal-00191901v1 2023-05-15T13:37:48+02:00 The fabp4 gene of zebrafish (Danio rerio)--genomic homology with the mammalian FABP4 and divergence from the zebrafish fabp3 in developmental expression. Liu, Rong-Zong Saxena, Vishal Sharma, Mukesh K Thisse, Christine Thisse, Bernard Denovan-Wright, Eileen M Wright, Jonathan M Institut de génétique et biologie moléculaire et cellulaire (IGBMC) Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) 2007-03 https://hal.science/hal-00191901 https://doi.org/10.1111/j.1742-4658.2007.05711.x en eng HAL CCSD Wiley info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1742-4658.2007.05711.x info:eu-repo/semantics/altIdentifier/pmid/17480210 hal-00191901 https://hal.science/hal-00191901 doi:10.1111/j.1742-4658.2007.05711.x PUBMED: 17480210 ISSN: 1742-464X EISSN: 1742-4658 FEBS Journal https://hal.science/hal-00191901 FEBS Journal, 2007, 274 (6), pp.1621-33. ⟨10.1111/j.1742-4658.2007.05711.x⟩ MESH: Amino Acid Sequence MESH: Animals MESH: Reverse Transcriptase Polymerase Chain Reaction MESH: Sequence Homology Amino Acid MESH: Zebrafish MESH: Zebrafish Proteins MESH: Base Sequence MESH: DNA Complementary MESH: Fatty Acid-Binding Proteins MESH: Gene Expression Regulation Developmental MESH: Genome MESH: Molecular Sequence Data MESH: Phylogeny MESH: RNA Messenger [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology info:eu-repo/semantics/article Journal articles 2007 ftunivnantes https://doi.org/10.1111/j.1742-4658.2007.05711.x 2023-02-08T08:15:52Z Teleost fishes differ from mammals in their fat deposition and distribution. The gene for adipocyte-type fatty acid-binding protein (A-FABP or FABP4) has not been identified thus far in fishes. We have determined the cDNA sequence and defined the structure of a fatty acid-binding protein gene (designated fabp4) from the zebrafish genome. The polypeptide sequence encoded by zebrafish fabp4 showed highest identity to the H(ad)-FABP or H6-FABP from Antarctic fishes and the putative orthologs from other teleost fishes (83-88%). Phylogenetic analysis clustered the zebrafish FABP4 with all Antarctic fish H6-FABPs and putative FABP4s from other fishes in a single clade, and then with the mammalian FABP4s in an extended clade. Zebrafish fabp4 was assigned to linkage group 19 at a distinct locus from fabp3. A number of closely linked syntenic genes surrounding the zebrafish fabp4 locus were found to be conserved with human FABP4. The zebrafish fabp4 transcripts showed sequential distribution in the developing eye, diencephalon and brain vascular system, from the middle somitogenesis stage to 48 h postfertilization, whereas fabp3 mRNA was located widely in the embryonic and/or larval central nervous system, retina, myotomes, pancreas and liver from middle somitogenesis to 5 days postfertilization. Differentiation in developmental regulation of zebrafish fabp4 and fabp3 gene transcription suggests distinct functions for these two paralogous genes in vertebrate development. Article in Journal/Newspaper Antarc* Antarctic Université de Nantes: HAL-UNIV-NANTES Antarctic FEBS Journal 274 6 1621 1633 |
institution |
Open Polar |
collection |
Université de Nantes: HAL-UNIV-NANTES |
op_collection_id |
ftunivnantes |
language |
English |
topic |
MESH: Amino Acid Sequence MESH: Animals MESH: Reverse Transcriptase Polymerase Chain Reaction MESH: Sequence Homology Amino Acid MESH: Zebrafish MESH: Zebrafish Proteins MESH: Base Sequence MESH: DNA Complementary MESH: Fatty Acid-Binding Proteins MESH: Gene Expression Regulation Developmental MESH: Genome MESH: Molecular Sequence Data MESH: Phylogeny MESH: RNA Messenger [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology |
spellingShingle |
MESH: Amino Acid Sequence MESH: Animals MESH: Reverse Transcriptase Polymerase Chain Reaction MESH: Sequence Homology Amino Acid MESH: Zebrafish MESH: Zebrafish Proteins MESH: Base Sequence MESH: DNA Complementary MESH: Fatty Acid-Binding Proteins MESH: Gene Expression Regulation Developmental MESH: Genome MESH: Molecular Sequence Data MESH: Phylogeny MESH: RNA Messenger [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology Liu, Rong-Zong Saxena, Vishal Sharma, Mukesh K Thisse, Christine Thisse, Bernard Denovan-Wright, Eileen M Wright, Jonathan M The fabp4 gene of zebrafish (Danio rerio)--genomic homology with the mammalian FABP4 and divergence from the zebrafish fabp3 in developmental expression. |
topic_facet |
MESH: Amino Acid Sequence MESH: Animals MESH: Reverse Transcriptase Polymerase Chain Reaction MESH: Sequence Homology Amino Acid MESH: Zebrafish MESH: Zebrafish Proteins MESH: Base Sequence MESH: DNA Complementary MESH: Fatty Acid-Binding Proteins MESH: Gene Expression Regulation Developmental MESH: Genome MESH: Molecular Sequence Data MESH: Phylogeny MESH: RNA Messenger [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology |
description |
Teleost fishes differ from mammals in their fat deposition and distribution. The gene for adipocyte-type fatty acid-binding protein (A-FABP or FABP4) has not been identified thus far in fishes. We have determined the cDNA sequence and defined the structure of a fatty acid-binding protein gene (designated fabp4) from the zebrafish genome. The polypeptide sequence encoded by zebrafish fabp4 showed highest identity to the H(ad)-FABP or H6-FABP from Antarctic fishes and the putative orthologs from other teleost fishes (83-88%). Phylogenetic analysis clustered the zebrafish FABP4 with all Antarctic fish H6-FABPs and putative FABP4s from other fishes in a single clade, and then with the mammalian FABP4s in an extended clade. Zebrafish fabp4 was assigned to linkage group 19 at a distinct locus from fabp3. A number of closely linked syntenic genes surrounding the zebrafish fabp4 locus were found to be conserved with human FABP4. The zebrafish fabp4 transcripts showed sequential distribution in the developing eye, diencephalon and brain vascular system, from the middle somitogenesis stage to 48 h postfertilization, whereas fabp3 mRNA was located widely in the embryonic and/or larval central nervous system, retina, myotomes, pancreas and liver from middle somitogenesis to 5 days postfertilization. Differentiation in developmental regulation of zebrafish fabp4 and fabp3 gene transcription suggests distinct functions for these two paralogous genes in vertebrate development. |
author2 |
Institut de génétique et biologie moléculaire et cellulaire (IGBMC) Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
format |
Article in Journal/Newspaper |
author |
Liu, Rong-Zong Saxena, Vishal Sharma, Mukesh K Thisse, Christine Thisse, Bernard Denovan-Wright, Eileen M Wright, Jonathan M |
author_facet |
Liu, Rong-Zong Saxena, Vishal Sharma, Mukesh K Thisse, Christine Thisse, Bernard Denovan-Wright, Eileen M Wright, Jonathan M |
author_sort |
Liu, Rong-Zong |
title |
The fabp4 gene of zebrafish (Danio rerio)--genomic homology with the mammalian FABP4 and divergence from the zebrafish fabp3 in developmental expression. |
title_short |
The fabp4 gene of zebrafish (Danio rerio)--genomic homology with the mammalian FABP4 and divergence from the zebrafish fabp3 in developmental expression. |
title_full |
The fabp4 gene of zebrafish (Danio rerio)--genomic homology with the mammalian FABP4 and divergence from the zebrafish fabp3 in developmental expression. |
title_fullStr |
The fabp4 gene of zebrafish (Danio rerio)--genomic homology with the mammalian FABP4 and divergence from the zebrafish fabp3 in developmental expression. |
title_full_unstemmed |
The fabp4 gene of zebrafish (Danio rerio)--genomic homology with the mammalian FABP4 and divergence from the zebrafish fabp3 in developmental expression. |
title_sort |
fabp4 gene of zebrafish (danio rerio)--genomic homology with the mammalian fabp4 and divergence from the zebrafish fabp3 in developmental expression. |
publisher |
HAL CCSD |
publishDate |
2007 |
url |
https://hal.science/hal-00191901 https://doi.org/10.1111/j.1742-4658.2007.05711.x |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
ISSN: 1742-464X EISSN: 1742-4658 FEBS Journal https://hal.science/hal-00191901 FEBS Journal, 2007, 274 (6), pp.1621-33. ⟨10.1111/j.1742-4658.2007.05711.x⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1742-4658.2007.05711.x info:eu-repo/semantics/altIdentifier/pmid/17480210 hal-00191901 https://hal.science/hal-00191901 doi:10.1111/j.1742-4658.2007.05711.x PUBMED: 17480210 |
op_doi |
https://doi.org/10.1111/j.1742-4658.2007.05711.x |
container_title |
FEBS Journal |
container_volume |
274 |
container_issue |
6 |
container_start_page |
1621 |
op_container_end_page |
1633 |
_version_ |
1766097839290580992 |